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Scholarly Works, Institute for Critical Technology and Applied Science (ICTAS)

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https://hdl.handle.net/10919/24353
Research articles, presentations, and other scholarship

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Browsing Scholarly Works, Institute for Critical Technology and Applied Science (ICTAS) by Author "Aardema, C.H."

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    Effects of internal electrode cooling on irreversible electroporation using a perfused organ model
    O’Brien, T. J.; Bonakdar, Mohammad; Bhonsle, Suyashree P.; Neal, Robert E.; Aardema, C.H.; Robertson, John L.; Goldberg, S.N.; Davalos, Rafael V. (Taylor and Francis Ltd, 2018-05-28)
    Purpose: This study evaluates the effects of active electrode cooling, via internal fluid circulation, on the irreversible electroporation (IRE) lesion, deployed electric current and temperature changes using a perfused porcine liver model. Materials and methods: A bipolar electrode delivered IRE electric pulses with or without activation of internal cooling to nine porcine mechanically perfused livers. Pulse schemes included a constant voltage, and a preconditioned delivery combined with an arc-mitigation algorithm. After treatment, organs were dissected, and treatment zones were stained using triphenyl-tetrazolium chloride (TTC) to demonstrate viability. Results: Thirty-nine treatments were performed with an internally cooled applicator and 21 with a non-cooled applicator. For the constant voltage scenario, the average final electrical current measured was 26.37 and 29.20 A for the cooled and uncooled electrodes respectively (p≤.001). The average final temperature measured was 33.01 and 42.43 °C for the cooled and uncooled electrodes respectively (p≤.0001). The average measured ablations (fixed lesion) were 3.88-by-2.08 cm and 3.86-by-2.12 cm for the cooled and uncooled electrode respectively (p≤.2495, p≤.7507). Similarly, the preconditioned/arc-mitigation scenario yielded an average final electrical current measurement of a 41.07 and 47.20 A for the cooled and uncooled electrodes respectively (p≤.0001). The average final temperature measured was 34.93 and 44.90 °C for the cooled and uncooled electrodes respectively (p≤.0001). The average measured ablations (fixed lesion) were 3.67-by-2.27 cm and 3.58-by-2.09 cm for the cooled and uncooled applicators ((p≤.7906; p≤.5595)). Conclusions: The internally-cooled bipolar applicator offers advantages that could improve clinical outcomes. Thermally mitigating internal perfusion technology reduced tissue temperatures and electric current while maintaining similar lesion sizes.