Browsing by Author "Baffoe-Bonnie, Anthony W."

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    Deepening Our Understanding of COVID-19 Vaccine Decision-Making amongst Healthcare Workers in Southwest Virginia, USA Using Exploratory and Confirmatory Factor Analysis
    Bendetson, Jesse; Swann, Mandy C.; Lozano, Alicia; West, Jennifer; Hanlon, Alexandra L.; Crandell, Ian; Jatta, Maimuna; Schleupner, Charles J.; Baffoe-Bonnie, Anthony W. (MDPI, 2023-02-27)
    Vaccine hesitancy amongst healthcare workers (HCWs) has been a major challenge throughout the COVID-19 pandemic. While many studies have identified HCW characteristics and specific attitudes associated with COVID-19 vaccine hesitancy, researchers are still working towards developing a holistic understanding of the psychological constructs that influence COVID-19 vaccine decision-making in this population. Between 15 March and 29 March 2021, we distributed an online survey assessing individual characteristics and vaccine-related perceptions to employees of a not-for-profit healthcare system in Southwest Virginia (N = 2459). We then performed exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) to describe patterns of vaccine-related thought amongst HCWs and identify latent psychometric constructs involved in vaccine decision-making. The goodness of model fit was assessed using the Tucker–Lewis Index (TLI), the Comparative Fit Index (CFI), and the Root Mean Square Error of Approximation (RMSEA). Internal consistency and reliability of each factor were assessed using Cronbach’s alpha. EFA identified four latent psychometric constructs: Lack of trust in the COVID-19 vaccine; Anti-science sentiment; Adverse side-effects; and Situational risk assessment. The goodness of EFA model fit was adequate (TLI > 0.90, RMSEA ≤ 0.08) with acceptable internal consistency and reliability for three of four factors (Cronbach’s alpha > 0.70). The CFA model also had adequate goodness of fit (CFI > 0.90, RMSEA ≤ 0.08). We believe the psychometric constructs identified in this study can provide a useful framework for interventions to improve vaccine uptake amongst this critical population.
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    Drug-Susceptible and Multidrug-Resistant Mycobacterium tuberculosis in a Single Patient
    Baffoe-Bonnie, Anthony W.; Houpt, Eric R.; Turner, Lauren; Dodge, Denise; Heysell, Scott K. (2019-11)
    A patient who had initial infection with mixed strains of drug-susceptible and multidrug-resistant tuberculosis was presumed to have acquired drug resistance before confirmation that sequential strains were genotypically distinct. Transmitted infection with mixed strains is likely underappreciated; identifying these infections requires spoligotyping and whole-genome sequencing.
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    Filtration evaluation and clinical use of expired elastomeric P-100 filter cartridges during the COVID-19 pandemic
    Patolia, Harsh H.; Pan, Jin; Harb, Charbel; Marr, Linsey C.; Baffoe-Bonnie, Anthony W. (Cambridge University Press, 2020-05-27)
    To the Editor—The limited supply of more conventional disposable personal protective equipment (PPE), namely single-use N95 filtering facepiece respirators (FFRs), among hospital systems in the United States during the COVID-19 pandemic has been alleviated with the adoption of extended use and reuse policies by the Centers for Disease Control and Prevention (CDC).1 These measures, along with a variety of implemented decontamination methodologies (eg, ultraviolet germicidal irradiation, vaporized hydrogen peroxide, etc), have prolonged PPE supplies during pressing times. Another strategy adopted by the CDC and health systems to protect healthcare providers caring for COVID-19 patients and patients under investigation in limited resource settings includes the use of elastomeric FFRs with reusable cartridges. Although elastomeric respirators have not been approved by the Food and Drug Administration for fluid resistance, they have been endorsed by the CDC as reasonable alternatives for N95 FFRs during the COVID-19 pandemic due to their filtration approval by the National Institutes for Occupational and Safety Health (NIOSH).2 Subsequently, elastomeric respirators have formed a major arm of the COVID-19 pandemic response strategy in many hospital systems...
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    A Rare Case of Mycobacterium chelonae Septic Joint
    Torres, Jordan L.; Zhao, Yang; Griffin, Daniel; Baffoe-Bonnie, Anthony W.; Grider, Douglas J.; Gomez, Mariana (2022-10-21)
    Background: Nontuberculous mycobacteria (NTM) are abundant in soil and water. They can cause infection by direct inoculation via even minimal trauma. Chronic soft tissue infection may extend to involve joints and underlying bone by direct extension. Septic joint infections due to NTM are rare and much of what is known about their management is either taken from case reports or extrapolated from the tuberculosis literature. Methods: Here we describe a case of septic ankle due to M. chelonae, a rapidly growing NTM. We also review the literature of mycobacterial infection, prognosis, and the treatment pharmacology of these difficult to treat infections. Results: An 86-year-old man presented to our hospital with complaints of a painful, swollen, left ankle. Three months earlier he had seen a pimple on his left foot after tripping over a lawn mower. The lesion evolved into erythema and swelling of the left ankle which was so painful that he could not bear weight on his left lower extremity (LLE). MRI of the LLE revealed a comminuted nondisplaced fracture of the distal tibial metaphysis. Turbid joint fluid was aspirated, and cell studies showed 211,450 k/uL white blood cells with 97% neutrophils. Patient underwent partial removal of the left tibia with insertion of a drug implant device. Tissue culture grew acid fast bacilli. Histopathology also showed acid-fast bacilli, confirming an atypical mycobacterial infection. Meropenem, linezolid, and azithromycin were initiated until the organism was identified as Mycobacterium chelonae. Based on susceptibility report, meropenem was discontinued, and ciprofloxacin was initiated. After discharge, a repeat MRI showed possible osteomyelitis and small abscesses about the left ankle. This prompted a repeat debridement. Tobramycin was started and ciprofloxacin was discontinued. The patient was re-admitted shortly after discharge with acute renal failure and lactic acidosis; he ultimately passed away on comfort care per patient and family wishes. Conclusion: NTM are more resistant to antimycobacterial therapy compared with mycobacteria tuberculosis (MTb) and repeat surgical debridement is often necessary for cure. Because these cases are rare, it is important to approach treatment as a team including ID physicians, ID pharmacists, and surgeons to improve outcomes.
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    Triple threat: Triple-valve endocarditis case report and literature review
    Vattikonda, Kiriti S.; Peterson, Christopher J.; Torres, Jordan L.; Sternberg, Michael; Okogbue, Ijeoma; Baffoe-Bonnie, Anthony W.; Fazili, Tasaduq (2023-10-12)
    Triple valve endocarditis (TVE) is a rare presentation of endocarditis often requiring multivalvular surgery. Here we report a case of S. aureus triple valve endocarditis in a patient with a history of intravenous drug use and provide a literature review of TVE identification, treatment, and prognosis.
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    Tuberculous Enteritis Presenting as Acute Appendicitis and Perirectal Abscess
    Okoro, Kelechukwu U.; De La Espriella, Maria Gomez; Grider, Douglas J.; Baffoe-Bonnie, Anthony W. (Hindawi, 2018-02-25)
    Mycobacterium tuberculosis has a wide variety of presentations. A rare occurrence is gastrointestinal tuberculosis. It may occur anywhere along the alimentary canal but usually occurs in the ileocecum with rare involvement of the appendix.
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    When Should Healthcare Workers With Coronavirus Disease 2019 (COVID-19) Return to Work? An Analysis of Follow-up Antigen Test Results After a Positive COVID Test
    Baffoe-Bonnie, Anthony W.; Swann, Mandy C.; Kim, Hyun Sue (Oxford University Press, 2023-03-03)
    A high percentage of healthcare workers (HCWs) who had met the Centers for Disease Control and Prevention criteria for returning to work 5 days after symptom onset remained positive for their return-to-work COVID-19 antigen test, suggesting continued infectiousness. Boosted HCWs were more likely to be antigen positive on their return-to-work test compared to unvaccinated HCWs, which merits further research.