Browsing by Author "Hussain, Shahzad"

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    A Case Series of E-cigarette or Vaping-Associated Lung Injury With a Review of Pathological and Radiological Findings
    Pourshahid, Seyedmohammad; Khademolhosseini, Sara; Hussain, Shahzad; Ie, Susanti R.; Cirino-Marcano, Maria Del Mar; Aziz, Sameh; Biscardi, Frank; Foroozesh, Mahtab (Cureus, 2022-05-08)
    There has been a recent outbreak of e-cigarette or vaping-associated lung injury (EVALI) but the exact pathophysiology remains unknown. Tetrahydrocannabinol (THC) and vitamin E derivates are the major components in vaping-generated aerosols that are associated with EVALI. So far, there is no standard treatment for EVALI. Most cases are treated with antibiotics and steroids. Counseling for smoking cessation is an integral part of care for EVALI patients. Referral to addiction medicine may be beneficial. Considering the nonspecific presenting symptoms and the growing popularity of vaping devices, providers need to consider EVALI in the differential diagnosis of bilateral patchy ground-glass opacities with respiratory, constitutional, or gastrointestinal symptoms in patients using e-cigarettes. Here, we present four EVALI cases and review the pertinent imaging and pathological findings.
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    A case series of endemic infections associated hemophagocytic lymphohistiocytosis (HLH) mimicking severe sepsis syndrome
    Kollipara, Venkateswara; Hussain, Shahzad; Franco-Palacios; Sofi, Umar (Elsevier, 2019-05-06)
    Hemophagocytic lymphohistiocytosis (HLH) is associated to high mortality and morbidity. A condition often underrecognized, HLH should be in the differential diagnosis of patients presenting with fever, cytopenia, hypertriglyceridemia and high ferritin levels (> 500 μg/L). Acquired or secondary HLH in adults is a heterogenous disease triggered by infectious, autoimmune, or neoplastic conditions. Infection associated HLH (IAHS) have been described in association to immunodeficiency and secondary to infections with endemic pathogens. Extensive investigation with microbiology, serology, urine antigens and biopsies of the bone marrow, lung or lymph nodes are often necessary. We present a series of three adult cases of HLH in patients admitted to the intensive care unit with a presumptive diagnosis of sepsis. Early recognition and treatment of this infection sometimes with concomitant administration of immunosuppressant therapy could impact the high mortality associated to this overlap syndrome.