Browsing by Author "Iglesias, Sandra"
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- Habitual daily intake of a sweet and fatty snack modulates reward processing in humansThanarajah, Sharmili Edwin; DiFeliceantonio, Alexandra G.; Albus, Kerstin; Kuzmanovic, Bojana; Rigoux, Lionel; Iglesias, Sandra; Hanßen, Ruth; Schlamann, Marc; Cornely, Oliver A.; Brüning, Jens C.; Tittgemeyer, Marc; Small, Dana M. (Elsevier, 2023-04-04)Western diets rich in fat and sugar promote excess calorie intake and weight gain; however, the underlying mechanisms are unclear. Despite a well-documented association between obesity and altered brain dopamine function, it remains elusive whether these alterations are (1) pre-existing, increasing the individual susceptibility to weight gain, (2) secondary to obesity, or (3) directly attributable to repeated exposure to western diet. To close this gap, we performed a randomized, controlled study (NCT05574660) with normal-weight participants exposed to a high-fat/high-sugar snack or a low-fat/low-sugar snack for 8 weeks in addition to their regular diet. The high-fat/high-sugar intervention decreased the preference for low-fat food while increasing brain response to food and associative learning independent of food cues or reward. These alterations were independent of changes in body weight and metabolic parameters, indicating a direct effect of high-fat, high-sugar foods on neurobehavioral adaptations that may increase the risk for overeating and weight gain.