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Browsing by Author "Jiang, X."

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    Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi
    Jiang, X.; Peery, A.; Hall, B.; Sharma, A.; Chen, X.-G.; Waterhouse, R. M.; Komissarov, A.; Riehle, M. M.; Shouche, Y.; Sharakhova, Maria V.; Lawson, D.; Pakpour, Nazzy; Arensburger, Peter; Davidson, V. L. M.; Eiglmeier, K.; Emrich, S.; George, P.; Kennedy, R. C.; Mane, S. P.; Maslen, G.; Oringanje, C.; Qi, Y.; Settlage, Robert E.; Tojo, M.; Tubio, J. M. C.; Unger, Maria F.; Wang, B.; Vernick, K. D.; Ribeiro, J. C.; James, A. A.; Michel, K.; Riehle, M. A.; Luckhart, Shirley; Sharakhov, Igor V.; Tu, Zhijian Jake (Biomed Central, 2014-01-01)
    Background: Anopheles stephensi is the key vector of malaria throughout the Indian subcontinent and Middle East and an emerging model for molecular and genetic studies of mosquito-parasite interactions. The type form of the species is responsible for the majority of urban malaria transmission across its range. Results: Here, we report the genome sequence and annotation of the Indian strain of the type form of An. stephensi. The 221 Mb genome assembly represents more than 92% of the entire genome and was produced using a combination of 454, Illumina, and PacBio sequencing. Physical mapping assigned 62% of the genome onto chromosomes, enabling chromosome-based analysis. Comparisons between An. stephensi and An. gambiae reveal that the rate of gene order reshuffling on the X chromosome was three times higher than that on the autosomes. An. stephensi has more heterochromatin in pericentric regions but less repetitive DNA in chromosome arms than An. gambiae. We also identify a number of Y-chromosome contigs and BACs. Interspersed repeats constitute 7.1% of the assembled genome while LTR retrotransposons alone comprise more than 49% of the Y contigs. RNA-seq analyses provide new insights into mosquito innate immunity, development, and sexual dimorphism. Conclusions: The genome analysis described in this manuscript provides a resource and platform for fundamental and translational research into a major urban malaria vector. Chromosome-based investigations provide unique perspectives on Anopheles chromosome evolution. RNA-seq analysis and studies of immunity genes offer new insights into mosquito biology and mosquito-parasite interactions.
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    Measurement of the Spectral Function of 40Ar through the (e, e'p) reaction
    Ankowski, Artur M.; Beminiwattha, R. S.; Benhar, Omar; Crabb, D. G.; Day, D. B.; Garibaldi, F.; Garvey, G. T.; Gaskell, D.; Giusti, C.; Hansen, O.; Higinbotham, D. W.; Holmes, R.; Jen, C. M.; Jiang, X.; Keller, D.; Keppel, C. E.; Lindgren, R.; Link, Jonathan M.; Liyanage, N.; Mariani, Camillo; Meucci, A.; Mills, G. B.; Myers, L.; Pitt, M. L.; Rondon, O. A.; Sakuda, M.; Sawatzky, B.; Souder, P. A.; Urciuoli, G. M.; Wood, S.; Zhang, J. (2014-07)
    The interpretation of the signals detected by high precision experiments aimed at measuring neutrino oscillations requires an accurate description of the neutrino-nucleus cross sections. One of the key element of the analysis is the treatment of nuclear effects, which is one of the main sources of systematics for accelerator based experiments such as the Long Baseline Neutrino Experiment (LBNE). A considerable effort is currently being made to develop theoretical models capable of providing a fully quantitative description of the neutrino-nucleus cross sections in the kinematical regime relevant to LBNE. The approach based on nuclear many-body theory and the spectral function formalism has proved very successful in explaining the available electron scattering data in a variety of kinematical conditions. The first step towards its application to the analysis of neutrino data is the derivation of the spectral functions of nuclei employed in neutrino detectors, in particular argon. We propose a measurement of the coincidence (e, e'p) cross section on argon. This data will provide the experimental input indispensable to construct the argon spectral function, thus paving the way for a reliable estimate of the neutrino cross sections. In addition, the analysis of the (e, e'p) data will help a number of theoretical developments, like the description of final-state interactions needed to isolate the initial-state contributions to the observed single-particle peaks, that is also needed for the interpretation of the signal detected in neutrino experiments.