Browsing by Author "Kahwati, Leila C."

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    AHRQ series on complex intervention systematic reviews-paper 4: selecting analytic approaches
    Viswanathan, Meera; McPheeters, Melissa L.; Hassan-Murad, M.; Butler, Mary E.; Devin, Emily E. (Beth); Dyson, Michele P.; Guise, Jeanne -Marie; Kahwati, Leila C.; Miles, Jeremy N. V.; Morton, Sally C. (2017-10)
    Background: Systematic reviews of complex interventions can vary widely in purpose, data availability and heterogeneity, and stakeholder expectations. Rationale: This article addresses the uncertainty that systematic reviewers face in selecting methods for reviews of complex interventions. Specifically, it lays out parameters for systematic reviewers to consider when selecting analytic approaches that best answer the questions at hand and suggests analytic techniques that may be appropriate in different circumstances. Discussion: Systematic reviews of complex interventions comprising multiple questions may use multiple analytic approaches. Parameters to consider when choosing analytic methods for complex interventions include nature and timing of the decision (clinical practice guideline, policy, or other); purpose of the review; extent of existing evidence; logistic factors such as the timeline, process, and resources for deciding the scope of the review; and value of information to be obtained from choosing specific systematic review methods. Reviewers may elect to revise their analytic approach based on new or changing considerations during the course of the review but should guard against bias through transparency of reporting. (C) 2017 The Authors. Published by Elsevier Inc.
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    AHRQ series on complex intervention systematic reviews-paper 5: advanced analytic methods
    Pigott, Terri; Noyes, Jane; Umscheid, Craig A.; Myers, Evan; Morton, Sally C.; Fu, Rongwei; Sanders-Schmidler, Gillian D.; Devine, Beth; Murad, M. Hassan; Kelly, Michael P.; Fonnesbeck, Christopher; Kahwati, Leila C.; Beretvas, S. Natasha (2017-10)
    Background and Objective: Advanced analytic methods for synthesizing evidence about complex interventions continue to be developed. In this paper, we emphasize that the specific research question posed in the review should be used as a guide for choosing the appropriate analytic method. Methods: We present advanced analytic approaches that address four common questions that guide reviews of complex interventions: (1) How effective is the intervention? (2) For whom does the intervention work and in what contexts? (3) What happens when the intervention is implemented? and (4) What decisions are possible given the results of the synthesis? Conclusion: The analytic approaches presented in this paper are particularly useful when each primary study differs in components, mechanisms of action, context, implementation, timing, and many other domains. (C) 2017 The Author(s). Published by Elsevier Inc.