Browsing by Author "Kim, Sun Hyung"
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- A collection of 157 individual neuromelanin-sensitive images accompanied by non-linear neuromelanin-sensitive atlas and a probabilistic locus coeruleus atlasLee, Tae-Ho; Kim, Sun Hyung; Neal, Joshua; Katz, Benjamin; Kim, Il Hwan (2024-02)The current dataset aims to support and enhance the research reliability of neuromelanin regions in the brain- stem, such as locus coeruleus (LC), by offering raw neuromelanin-sensitive images. The dataset includes raw neuromelanin-sensitive images from 157 healthy individuals (8–64 years old). In addition, leveraging individual neuromelanin-sensitive images, a non-linear neuromelanin- sensitive atlas, generated through an iterative warping pro- cess, is included to tackle the common challenge of a limited field of view in neuromelanin-sensitive images. Finally, the dataset encompasses a probabilistic LC atlas generated through a majority voting approach with pre-existing multiple atlas-based segmentations. This process entails warping pre-existing atlases onto individual spaces and identifying voxels with a majority consensus of over 50 % across the atlases. This LC probabilistic atlas can minimize uncertainty variance associated with choosing a specific single atlas.
- The Decline in Intrinsic Connectivity Between the Salience Network and Locus Coeruleus in Older Adults: Implications for DistractibilityLee, Tae-Ho; Kim, Sun Hyung; Katz, Benjamin; Mather, Mara (2020-01-31)We examined functional connectivity between the locus coeruleus (LC) and the salience network in healthy young and older adults to investigate why people become more prone to distraction with age. Recent findings suggest that the LC plays an important role in focusing processing on salient or goal-relevant information from multiple incoming sensory inputs (Mather et al., 2016). We hypothesized that the connection between LC and the salience network declines in older adults, and therefore the salience network fails to appropriately filter out irrelevant sensory signals. To examine this possibility, we used resting-state-like fMRI data, in which all task-related activities were regressed out (Fair et al., 2007; Elliott et al., 2019) and performed a functional connectivity analysis based on the time-course of LC activity. Older adults showed reduced functional connectivity between the LC and salience network compared with younger adults. Additionally, the salience network was relatively more coupled with the frontoparietal network than the default-mode network in older adults compared with younger adults, even though all task-related activities were regressed out. Together, these findings suggest that reduced interactions between LC and the salience network impairs the ability to prioritize the importance of incoming events, and in turn, the salience network fails to initiate network switching (e.g., Menon and Uddin, 2010; Uddin, 2015) that would promote further attentional processing. A chronic lack of functional connection between LC and salience network may limit older adults' attentional and executive control resources.
- Editorial: Similarities and Discrepancies Across Family Members at Multiple Levels: Insights From Behavior, Psychophysiology, and NeuroimagingRogers, Christy Rae; Qu, Yang; Lee, Tae-Ho; Liu, Siwei; Kim, Sun Hyung (Frontiers, 2022-01-28)