Browsing by Author "Kiupel, M."
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- Clinical prognostic factors in canine histiocytic sarcoma.Dervisis, Nikolaos G.; Kiupel, M.; Qin, Q.; Cesario, L. (2016-06-23)Canine histiocytic sarcoma (HS) is an aggressive neoplasia with variable clinical course and fatal outcome. The goals of this study were to evaluate a large cohort of canine patients with immunohistochemically confirmed HS and identify clinical prognostic factors. Biopsy submissions to the Michigan State University with tentative HS diagnoses were histologically and immunohistochemically confirmed, medical records collected, and interviews with relevant veterinary clinics conducted. Of 1391 histopathology submissions with a diagnosis containing the word ‘histiocytic’, 335 were suspicious for malignancy, and 180 were consistent with HS and had adequate clinical information recorded. The most commonly represented breeds were Bernese mountain dogs (n=53), labrador retrievers (n=26) and golden retrievers (n=17). Median survival for all dogs in the study was 170 days, and subgroup analysis identified palliative treatment, disseminated HS, and concurrent use of corticosteroids as statistically significant negative factors for survival, in both uni- and multi-variate methodologies.
- Recommended Guidelines for the Conduct and Evaluation of Prognostic Studies in Veterinary OncologyWebster, J. D.; Dennis, M. M.; Dervisis, Nikolaos G.; Heller, J.; Bacon, N. J.; Bergman, P. J.; Bienzle, D.; Cassali, G.; Castagnaro, M.; Cullen, J.; Esplin, D. G.; Pena, L.; Goldschmidt, M. H.; Hahn, K. A.; Henry, C. J.; Hellmen, E.; Kamstock, D.; Kirpensteijn, J.; Kitchell, B. E.; Amorim, R. L.; Lenz, S. D.; Lipscomb, T. P.; McEntee, M.; McGill, L. D.; McKnight, C. A.; McManus, P. M.; Moore, A. S.; Moore, P. F.; Moroff, S. D.; Nakayama, H.; Northrup, N. C.; Sarli, G.; Scase, T.; Sorenmo, K.; Schulman, F. Y.; Shoieb, A. M.; Smedley, R. C.; Spangler, W. L.; Teske, E.; Thamm, D. H.; Valli, V. E.; Vernau, W.; von Euler, H.; Withrow, S. J.; Weisbrode, S. E.; Yager, J.; Kiupel, M. (SAGE, 2011-01-01)There is an increasing need for more accurate prognostic and predictive markers in veterinary oncology because of an increasing number of treatment options, the increased financial costs associated with treatment, and the emotional stress experienced by owners in association with the disease and its treatment. Numerous studies have evaluated potential prognostic and predictive markers for veterinary neoplastic diseases, but there are no established guidelines or standards for the conduct and reporting of prognostic studies in veterinary medicine. This lack of standardization has made the evaluation and comparison of studies difficult. Most important, translating these results to clinical applications is problematic. To address this issue, the American College of Veterinary Pathologists’ Oncology Committee organized an initiative to establish guidelines for the conduct and reporting of prognostic studies in veterinary oncology. The goal of this initiative is to increase the quality and standardization of veterinary prognostic studies to facilitate independent evaluation, validation, comparison, and implementation of study results. This article represents a consensus statement on the conduct and reporting of prognostic studies in veterinary oncology from veterinary pathologists and oncologists from around the world. These guidelines should be considered a recommendation based on the current state of knowledge in the field, and they will need to be continually reevaluated and revised as the field of veterinary oncology continues to progress. As mentioned, these guidelines were developed through an initiative of the American College of Veterinary Pathologists’ Oncology Committee, and they have been reviewed and endorsed by the World Small Animal Veterinary Association.