Browsing by Author "Lee, Grace"

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    Drawing Through 4 Seasons
    Lee, Grace (Virginia Tech, 2009-10-07)
    This thesis is concerned with architecture and its changes through four seasons. It is about drawing new images of a building in different seasons. Like trees change their leaves in seasons and like people change their clothes in seasons, this project is about architecture changing its architectural elements in four seasons. It all began with an imagination of how a building would respond differently in each of the four seasons. The project, located at the waterfront of Old Town, Alexandria, Virginia, is an Aquatic Center with swimming pools, changing areas, saunas, fitness area, and massage areas. The Aquatic Center creates different images to its visitors through surrounding natures and their changes, architectural elements and their movements, visitors and their activities. The goal was to provide people unique and different experiences every time they visit.
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    Regulation of neonatal IgA production by the maternal microbiota
    Mu, Qinghui; Swartwout, Brianna K.; Edwards, Michael R.; Zhu, Jing; Lee, Grace; Eden, Kristin; Cabana-Puig, Xavier; McDaniel, Dylan K.; Mao, Jiangdi; Abdelhamid, Leila; Brock, Rebecca M.; Allen, Irving C.; Reilly, Christopher M.; Luo, Xin M. (National Academy of Sciences, 2021-02-22)
    Infants are prone to enteric infections due to an underdeveloped immune system. The maternal microbiota, through shaping the neonatal microbiota, helps establish a strong immune system in infants. We and others have observed the phenomenon of enhanced early neonatal immunoglobulin A (IgA) production in preweaning immunocompetent mice nursed by immunodeficient dams. Here, we show that this enhancement of IgA in neonates results from maternally derived microbiota. In addition, we have found that the neonatal IgA production can be induced by Lactobacillus reuteri, which is enriched in the milk of immunodeficient dams. Moreover, we show that while the production of neonatal IgA is dependent on neonatal T cells, the immunodeficient maternal microbiota-mediated enhancement of neonatal IgA has a T cell– independent component. Indeed, this enhancement may be dependent on type 3 innate lymphoid cells in the neonatal small intestinal lamina propria. Interestingly, maternal microbiotainduced neonatal IgA does not cross-react with common enteric pathogens. Future investigations will determine the functional consequences of having this extra IgA.