Browsing by Author "Lewis, Claude Irenius"

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    The synthesis of 10-(4-hydroxymethylphenyl)-1,2-Benzanthracene
    Lewis, Claude Irenius (Virginia Polytechnic Institute, 1959)
    A. The alcohol, 10-(4’-hydroxymethylphenyl)-1,2-benzanthracene, was prepared by the reduction or 10-(4’-carboxyphenyl)- 1,2- benzanthracene. The structure or the alcohol was proven by: (1) Ultraviolet spectra (2) Infrared spectra (3) Elementary analysis (4) Preparation or the benzoate B. The preparation of the Grignard reagent of 10-(4’-bromophenyl)-1,2-benzanthracene was unsuccessful. An explanation of this anomaly was not discovered. C. The Grignard reagent or 2-(1-naphthylmethyl)-chloro-benzene was prepared by the use or tetrahydrofuran and "entrainment" with methyl iodide.
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    The synthesis of some substituted 7-(1-Naphthyl)- Benz(a)Anthracenes
    Lewis, Claude Irenius (Virginia Tech, 1962-06-15)
    Many benz(a)anthracene derivatives are able to produce cancer in the experimental animal. There is a correlation between the calculated total electronic charge of the K-region and this carcinogenic activity. There is also ample proof that benz(a)anthracene derivatives are honed to the skin through quinoid type bonds in the K"region. However, the prediction of physiological activity of benz(a)anthracenes is still unreliable because of the limitations of the theoretical model described by existing theories. The purpose of this work was to synthesize some substituted benz(a)anthracenes with a shielded K-region and with a different L-region electron density than in 7-phenyl-bena(a)anthracene in the hope of increasing our knowledge regarding molecular structure-physiological relationship.