Browsing by Author "Mir, Adil Shamim"

Now showing 1 - 3 of 3
  • Thumbnail Image
    Bleeding Gastric Lipoma Resected by Endoscopic Submucosal Dissection
    Mir, Adil Shamim; Kesar, Varun; Sageer, Mohamed; Grider, Douglas J.; Chitnavis, Vikas (2020-06-29)
    Gastric lipomas are slow-growing benign lesions of the stomach that are often detected incidentally. Most cases are asymptomatic but larger lesions may become symptomatic, thereby requiring treatment. Multiple endoscopic modalities have been used for resection in the past. We present the case of a 67-year-old patient who presented with upper GI bleeding secondary to a gastric lipoma, which was successfully resected by endoscopic submucosal dissection.
  • Thumbnail Image
    Immunomodulation and Generation of Tolerogenic Dendritic Cells by Probiotic Bacteria in Patients with Inflammatory Bowel Disease
    Ghavami, Shaghayegh Baradaran; Yadegar, Abbas; Aghdaei, Hamid Asadzadeh; Sorrentino, Dario; Farmani, Maryam; Mir, Adil Shamim; Azimirad, Masoumeh; Balaii, Hedieh; Shahrokh, Shabnam; Zali, Mohammad Reza (2020-09)
    In inflammatory bowel diseases (IBD), the therapeutic benefit and mucosal healing from specific probiotics may relate to the modulation of dendritic cells (DCs). Herein, we assessed the immunomodulatory effects of four probiotic strains includingLactobacillus salivarius,Bifidobacterium bifidum,Bacillus coagulansandBacillus subtilisnatto on the expression of co-stimulatory molecules, cytokine production and gene expression of signal-transducing receptors in DCs from IBD patients. Human monocyte-derived DCs from IBD patients and healthy controls were exposed to four probiotic strains. The expression of co-stimulatory molecules was assessed and supernatants were analyzed for anti-inflammatory cytokines. The gene expression of toll-like receptors (TLRs), IL-12p40 and integrin alpha v beta 8 were also analyzed. CD80 and CD86 were induced by most probiotic strains in ulcerative colitis (UC) patients whereas onlyB. bifiduminduced CD80 and CD86 expression in Crohn's disease (CD) patients. IL-10 and TGF-beta production was increased in a dose-independent manner while TLR expression was decreased by all probiotic bacteria exceptB. bifidumin DCs from UC patients. TLR-4 and TLR-9 expression was significantly downregulated while integrin ss8 was significantly increased in the DCs from CD patients. IL-12p40 expression was only significantly downregulated in DCs from CD patients. Our findings point to the general beneficial effects of probiotics in DC immunomodulation and indicate that probiotic bacteria favorably modulate the expression of co-stimulatory molecules, proinflammatory cytokines and TLRs in DCs from IBD patients.
  • Thumbnail Image
    Wireless Capsule Endoscopy for Diagnosis and Management of Post-Operative Recurrence of Crohn’s Disease
    Mir, Adil Shamim; Nguyen, Vu Q.; Soliman, Youssef; Sorrentino, Dario (MDPI, 2021-06-23)
    Despite aggressive medical therapy, many patients with Crohn’s disease require surgical intervention over time. After surgical resection, disease recurrence is common. Ileo-colonoscopy and the Rutgeerts score are commonly used for diagnosis and monitoring of post-operative endoscopic recurrence. The latter is the precursor of clinical recurrence and therefore it impacts prognosis and patient management. However, due to the limited length of bowel assessed by ileo-colonoscopy, this procedure can miss out-of-reach, more proximal lesions in the small bowel. This limitation introduces an important uncertainty when evaluating post-operative relapse by ileo-colonoscopy. In addition, the Rutgeerts score ‘per se’ bears a number of ambiguities. Here we will discuss the pros and cons of ileo-colonoscopy and other imaging studies including wireless capsule endoscopy to diagnose and manage post-operative recurrence of Crohn’s disease. A number of studies provide evidence that wireless capsule endoscopy is a potentially more accurate as well as less invasive and less costly alternative to conventional techniques including ileo-colonoscopy.