Browsing by Author "Ranjan, Ashish"

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    5th International Symposium on Focused Ultrasound
    Abounader, Roger; Abraham, Christopher; Adema, Gosse; Agrawal, Punit; Airan, Raag; Aleman, Dionne; Alexander, Phillip; Alkins, Ryan; Alnazeer, Moez; Altman, Michael; Aly, Amirah; Amaral, Joao G.; Amrahli, Maral; Amraoui, Sana; Andarawewa, Kumari; Andriyakhina, Yulia; Angstadt, Mary; Ankou, Bénédicte; Arias, Ana C.; Arvanitis, Costas; Asadnia, Kiana; Aubert, Isabelle; Aubry, Jean-Francois; Aubry, Jean-Francois; Aurup, Christian; Bader, Kenneth; Badr, Lena; Baek, Hongchae; Barbato, Gaetano; Beccaria, Kevin; Bellorofonte, Carlo; Benson, Lee; Bernus, Olivier; Berriet, Rémi; Bertolina, Jim; Beskin, Viktoriya; Bessière, Francis; Bethune, Allison; Bezzi, Mario; Bond, Aaron; Bonomo, Guido; Borowsky, Alexander; Borys, Nicolas; Böttcher, Joachim; Bouley, Donna; Bour, Pierre; Bourekas, Eric; Brenin, David; Brokman, Omer; Brosh, Inbar; Buckner, Andrew; Bullock, Timothy; Cafarelli, Andrea; Cahill, Jessica; Camarena, Francisco; Camelo-Piragua, Sandra; Campbell, Benjamin; Campbell, Fiona; Cannata, Jon; Canney, Michael; Carlson, Roy; Carneiro, Antonio; Carpentier, Alexandre; Catheline, Stefan; Cavin, Ian; Cesana, Claudio; Chabok, Hamid R.; Chamanara, Marzieh; Chang, Jin H.; Chang, Won S.; Changizi, Barbara; Chapelon, Jean Y.; Chaplin, Vandiver; Chapman, Martin; Chaudhary, Neeraj; Chaussy, Christian; Chen, Cherry; Chen, Johnny; Chen, Wohsing; Chen, Xiaoming; Chevalier, Philippe; Chiou, George; Chisholm, Alexander; Christofferson, Ivy; Chung, Hyun H.; Ciuti, Gastone; Clement, Gregory; Cooper, Mark; Corea, Joseph; Corso, Cristiano; Cosman, Josh; Coughlin, Dezba; Crake, Calum; Cunitz, Bryan; Curiel, Laura; Curley, Colleen T.; Czarnota, Gregory; Dababou, Susan; Dallapiazza, Robert; de Bever, Joshua; de Jager, Bram; de Ruiter, Joost; de Senneville, Baudouin D.; Deckers, Roel; Delattre, Jean-Yves; den Brok, Martijn; Dhanaliwala, Ali; Diodato, Alessandro; Dixon, Adam; Donner, Elizabeth; Downs, Matthew; Du, Zhongmin; Dubois, Rémi; Dupre, Aurelien; Eikelenboom, Dylan; Elias, W. J.; Ellens, Nicholas; Endre, Ruby; Eran, Ayelet; Erasmus, Hans-Peter; Everstine, Ashli; Farahani, Keyvan; Farrer, Alexis; Farry, Justin; Federau, Christian; Feng, Xue; Ferrer, Cyril; Ferrera, Vincent; Fishman, Paul; Foley, Jessica; Frenkel, Victor; Fütterer, Jurgen; Gach, H. M.; Gandhi, Dheeraj; Gertner, Michael; Goldsher, Dorit; Gorgone, Alessandro; Greillier, Paul; Griesenauer, Rebekah; Grissom, William; Grondin, Julien; Guha, Chandan; Gulati, Amitabh; Gullapalli, Rao; Guo, Sijia; Gupta, Samit; Gurm, Hitinder; Gwinn, Ryder; Hadley, Rock; Haïssaguerre, Michel; Hammoud, Dima; Hananel, Arik; Hargrove, Amelia; Hatch, Robert; Haworth, Kevin; Hazan, Eilon; He, Ye; Heemels, Maurice; Heerschap, Arend; Hilas, Elaine; Hoang-Xuan, Khe; Hocini, Mélèze; Hodaie, Mojgan; Hofmann, Denis; Holland, Christy; Hoogenboom, Martijn; Hopyan, Sevan; Hossack, John; Houdouin, Alexandre; Hsu, Po-Hung; Hu, Jim; Hurwitz, Mark; Huss, Diane; Hwang, Chang-il; Hwang, Joo H.; Idbaih, Ahmed; Ikeuchi, Masahiko; Ingham, Elizabeth; Ives, Kimberly; Izumi, Masashi; Jackson-Lewis, Vernice; Janát-Amsbury, Margit; Jang, Kee W.; Jedruszczuk, Kathleen; Jiménez-Gambín, Sergio; Jiménez, Noé; Johnson, Sara; Jonathan, Sumeeth; Joy, Joyce; Jung, Hyun H.; Jung, Na Y.; Kahn, Itamar; Kamimura, Hermes; Kamrava, Seyed K.; Kang, Jeeun; Kang, Kook J.; Kang, Soo Y.; Kao, Yi-tzu; Katti, Prateek; Kawasaki, Motohiro; Kaye, Elena; Keupp, Jochen; Kim, AeRang; Kim, Harry; Kim, Hyun-Chul; Kim, Hyuncheol; Kim, Hyungmin; Kim, Min S.; Kim, Namho; Kiyasu, Katsuhito; Kneepkens, Esther; Knopp, Michael; Kobus, Thiele; Koral, Korgun; Kreider, Wayne; Krishna, Vibhor; Krug, Roland; Krupa, Steve; Kuo, Chia-Chun; Kwiecinski, Wojciech; Lacoste, Romain; Lam, Heather; Lamberti-Pasculli, Maria; Lang, Brian; Larner, James; Larrabee, Zachary; Leach, J. K.; LeBlang, Suzanne; Leclercq, Delphine; Lee, Hak J.; Lee, Jong-Hwan; Lehericy, Stéphane; Leighton, Wan; Leung, Steven; Lewis, Bobbi; Lewis, Matthew; Li, Dawei; Linn, Sabine; Lipsman, Nir; Liu, Hao-Li; Liu, Jingfei; Lopes, M. B.; Lotz, Jeff; Lu, Xin; Lundt, Jonathan; Luo, Xi; Lustgarten, Lior; Lustig, Micheal; Macoskey, Jonathan; Madore, Bruno; Maev, Roman; Magat, Julie; Maimbourg, Guillaume; Maimon, Noam; Mainprize, Todd; Malayer, Jerry; Maples, Danny; Marquet, Fabrice; Marrocchio, Cristina; Marx, Mike; Mastorakos, Panagiotis; Mauri, Giovanni; McLean, Hailey; McMichael, John; Mead, Brian P.; Melodelima, David; Melot-Dusseau, Sandrine; Menciassi, Arianna; Merrill, Robb; Meyer, Joshua; Midiri, Massimo; Miga, Michael; Migliore, Ilaria G.; Miller, Eric; Minalga, Emilee; Moon, Hyungwon; Moore, David; Mourad, Pierre; Mouratidis, Petros; Mueller, Michael; Mugler, John; Muller, Sébastien; Namba, Hirofumi; Naor, Omer; Nassar, Maria; Nazai, Navid; Negron, Karina; Negussie, Ayele; Nguyen, Thai-Son; Nicolay, Klaas; Nikolaeva, Anastasia V.; Oetgen, Matthew; Olive, Kenneth; Olumolade, Oluyemi; Orsi, Franco; Owens, Gabe; Ozilgen, Arda; Padegimas, Linas; Palermo, Carmine; Pan, Chia-Hsin; Pandey, Aditya; Papadakis, Georgios; Park, Chang K.; Park, Sang M.; Parker, Jonathon; Parvizi, Mohammad H.; Pascal-Tenorio, Aurea; Patel, Janish; Patz, Sam; Payen, Thomas; Perich, Eloi; Pernot, Mathieu; Perol, David; Perry, James; Pillarisetty, Venu; Pioche, Mathieu; Pizzuto, Matthew; Plaksin, Michael; Plata, Juan; Price, Karl; Prince, Jessica; Przedborski, Serge; Quinones-Hinojosa, Alfredo; Ramachandran, Akhilesh; Ranjan, Ashish; Ravikumar, Vinod; Reichenbach, Juergen; Repasky, Elizabeth; Rezai, Ali; Ritter, Philippe; Rivoire, Michel; Rochman, Carrie; Rosenberg, Jarrett; Rosnitskiy, Pavel B.; Ruiz, Antonio; Sahgal, Arjun; Samiotaki, Gesthimani; Sanghvi, Narendra; Santin, Mathieu D.; Santos, Domiciano; Sasaki, Noboru; Sastra, Steve; Schade, George; Schall, Jeffrey; Schlesinger, Ilana; Schmitt, Paul; Schwaab, Julia; Scionti, Stephen; Scipione, Roberto; Scoarughi, Gian L.; Scott, Serena; Sebeke, Lukas; Seifabadi, Reza; Seo, Jai; Sesenoglu-Laird, Ozge; Shah, Binit; Shahriari, Kian; Shaikh, Sumbul; Shea, Jill; Shi, Jiaqi; Shim, Jenny; Shinkov, Alexander; Shuman, Jillian; Silvestrini, Matthew; Sim, Changbeom; Sin, Vivian; Sinai, Alon; Singh, Manoj; Sinilshchikov, Ilya; Skalina, Karin; Slingluff, Craig; So, Po-Wah; Solomon, Stephen; Son, Keon H.; Sperling, Scott; Stein, Ruben; Stein, Sherman; Stevens, Aaron; Stimec, Jennifer; Storm, Gert; Straube, William; Suelmann, Britt; Sutton, Jonathan; Svedin, Bryant; Takemasa, Ryuichi; Takiguchi, Mitsuyoshi; Tam, Emily; Tan, Jeremy; Tang, Xinyan; Tanter, Mickael; Tebebi, Pamela; Tehrani, Seruz; Temple, Michael; Teofilovic, Dejan; ter Haar, Gail; Terzi, Marina E.; Thueroff, Stefan; Timbie, Kelsie; Tognarelli, Selene; Tretbar, Steffen; Trudeau, Maureen; Tsai, Yi-Chieh; Tsysar, Sergey A.; Tucci, Samantha; Tuveson, David; Ushida, Takahiro; Vaessen, Paul; Vaillant, Fanny; Van Arsdell, Glen; van Breugel, Johanna; Van der Jeugd, Anneke; Van der Jeugd, Anneke; Van der Wall, Elsken; van Diest, Paul; van Stralen, Marijn; Varano, Gianluca; Velat, Manuela; Vidal-Jove, Joan; Vigna, Paolo D.; Vignot, Alexandre; Vincenot, Jeremy; Vykhodtseva, Natalia; Wang, Bin; Wang, Han; Wang, Kevin; Wang, Qi; Wang, Qingguo; Wang, Shengping; Wang, Yak-Nam; Wang, Zhaorui; Wardlow, Rachel; Warren, Amy; Waszczak, Barbara; Watson, Katherine; Webb, Taylor; Wei-Bin, Shen; Wei, Kuo-Chen; Weiss, Steffen; Weissler, Yoni; Werner, Beat; Wesseling, Pieter; Williams, Noelle; Wilson, Emmanuel; Wintermark, Max; Witkamp, Arjen; Wong, Carlos; Wu, Jing-Fu; Wydra, Adrian; Xu, Alexis; Xu, Doudou; Xu, Su; Yang, Georgiana; Yang, Nai-Yi; Yao, Chen; Yarowsky, Paul; Ye, Patrick P.; Yuldashev, Petr; Zaaroor, Menashe; Zachiu, Cornel; Zahos, Peter; Zangos, Stephan; Zhang, Dandan; Zhang, Hua; Zhang, Jimin; Zhang, Junhai; Zhang, Xi; Zhao, Li; Zhong, Pei; Zhuo, Jiachen; Zidowitz, Stephan; Zinke, Wolf; Zorgani, Ali (2016-11-21)
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    Antibacterial efficacy of core-shell nanostructures encapsulating gentamicin against an in vivo intracellular Salmonella model
    Ranjan, Ashish; Pothayee, Nikorn; Seleem, Mohamed N.; Tyler, Ronald D.; Brenseke, Bonnie; Sriranganathan, Nammalwar; Riffle, Judy S.; Kasimanickam, Ramanathan K. (Dove Medical Press, 2009-01-01)
    Pluronic based core-shell nanostructures encapsulating gentamicin were designed in this study. Block copolymers of (PAA(+/-)Na-b-(PEO-b-PPO-b-PEO)-b-PAA(+/-)Na) were blended with PAA(-) Na(+) and complexed with the polycationic antibiotic gentamicin to form nanostructures. Synthesized nanostructures had a hydrodynamic diameter of 210 nm, zeta potentials of -0.7 (+/-0.2), and incorporated approximately 20% by weight of gentamicin. Nanostructures upon co-incubation with J774A.1 macrophage cells showed no adverse toxicity in vitro. Nanostructures administered in vivo either at multiple dosage of 5 microg g(-1) or single dosage of 15 microg g(-1) in AJ-646 mice infected with Salmonella resulted in significant reduction of viable bacteria in the liver and spleen. Histopathological evaluation for concentration-dependent toxicity at a dosage of 15 microg g(-1) revealed mineralized deposits in 50% kidney tissues of free gentamicin-treated mice which in contrast was absent in nanostructure-treated mice. Thus, encapsulation of gentamicin in nanostructures may reduce toxicity and improve in vivo bacterial clearance.
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    Development of core-shell nanostructure encapsulating gentamicin as efficient drug delivery system against intracellular Salmonella
    Ranjan, Ashish (Virginia Tech, 2009-09-10)
    Intracellular pathogens like Salmonella have developed various mechanisms to evade host defenses, and they can establish infections. Treatment and eradication are difficult due to our inability in achieving the optimum concentrations of cell-impermeable aminoglycosides like gentamicin within these cells. In this dissertation, we hypothesize that developing a novel core-shell methodology for incorporating high amounts of gentamicin into the cores with either hydrophilic or amphiphilic shell will be more effective than the free gentamicin in clearing intracellular Salmonella infection. Hydrophilic core-shell nanostructures (N1) were made with block co-polymers of poly (ethylene oxide-b-sodium acrylate) blended with sodium polyacrylate (PAA-+Na) and complexed with the polycationic antibiotic gentamicin. N1 showed 20-25 fold higher gentamicin loading than the currently existing materials and reduced numbers of viable Salmonella in the liver and spleen compared to free gentamicin. To further improve the rate and route of uptake, the shell of the nanostructures were made amphiphilic by incorporating pluronics F68 (PPO)₆₈ in the block copolymer. We showed that core-shell nanostructures encapsulating gentamicin having (PPO)₆₈ in the shell (N2) enhances the rate and modulates the route of uptake into macrophages, thus promoting significant reduction in the intracellular Salmonella in-vitro and in-vivo. The main drawback of N2 was its poor stability at physiological pH of 7.4, 0.1 M NaCl. Therefore, core-shell nanostructures encapsulating gentamicin containing pluronic P85 (PPO)₈₅ in the shell (N3) with improved colloidal and ionic stability were designed. N3 achieved significant intracellular reduction of vacuolar Salmonella (0.53 log₁₀) and cytoplasm resident Listeria (3.11 log₁₀) compared to free gentamicin in-vitro. However, greater reduction of Listeria suggested that sub-cellular localization of bacterium influences targeting by N3. Even though oral administration of N3 was not effective compared to free gentamicin, parenteral (I.P.) administration significantly reduced the intracellular Salmonella from liver and spleen compared to free gentamicin and appeared to have no abnormal in-vivo toxicity. In summary, core-shell nanostructures encapsulating gentamicin (N) with improved encapsulation efficiency and different shell chemistry (N1, N2 and N3) were developed with enhanced efficacy against intracellular Salmonella. The novel gentamicin delivery approach developed in this study may be applicable for therapy of many intracellular infections.
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    A Spectral Fiedler Field-based Contrast Platform for Imaging of Nanoparticles in Colon Tumor
    Liu, Chenang; Kapoor, Ankur; VanOsdol, Joshua; Ektate, Kalyani; Kong, Zhenyu; Ranjan, Ashish (Springer Nature, 2018-07-30)
    The temporal and spatial patterns of nanoparticle that ferry both imaging and therapeutic agent in solid tumors is significantly influenced by target tissue movement, low spatial resolution, and inability to accurately define regions of interest (ROI) at certain tissue depths. These combine to limit and define nanoparticle untreated regions in tumors. Utilizing graph and matrix theories, the objective of this project was to develop a novel spectral Fiedler field (SFF) based-computational technology for nanoparticle mapping in tumors. The novelty of SFF lies in the utilization of the changes in the tumor topology from baseline for contrast variation assessment. Data suggest that SFF can enhance the spatiotemporal contrast compared to conventional method by 2-3 folds in tumors. Additionally, the SFF contrast is readily translatable for assessment of tumor drug distribution. Thus, our SFF computational platform has the potential for integration into devices that allow contrast and drug delivery applications.