Browsing by Author "Rekosh, David"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Effect of intercalator and Lewis acid-base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNA
    Wynn, Jessica E.; Zhang, Wenyu; Tebit, Denis M.; Gray, Laurie R.; Hammarskjold, Marie-Louise; Rekosh, David; Santos, Webster L. (Royal Society of Chemistry, 2016-06-06)
    High throughput screening of a 4096 compound library of boronic acid and acridine containing branched peptides revealed compounds that have dissociation constants in the low nanomolar regime for HIV-1 RRE IIB RNA. We demonstrate that branched peptide boronic acids A5, A6, and A7 inhibit the production of p24, an HIV-1 capsid protein, in a dose-dependent manner.