Browsing by Author "Sandberg, Stefan G."

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    Sub-Second Dopamine Detection in Human Striatum
    Kishida, Kenneth T.; Sandberg, Stefan G.; Lohrenz, Terry; Comair, Youssef G.; Sáez, Ignacio; Phillips, Paul E. M.; Montague, P. Read (PLOS, 2011-08-04)
    Fast-scan cyclic voltammetry at carbon fiber microelectrodes allows rapid (sub-second) measurements of dopamine release in behaving animals. Herein, we report the modification of existing technology and demonstrate the feasibility of making sub-second measurements of dopamine release in the caudate nucleus of a human subject during brain surgery. First, we describe the modification of our electrodes that allow for measurements to be made in a human brain. Next, we demonstrate in vitro and in vivo, that our modified electrodes can measure stimulated dopamine release in a rat brain equivalently to previously determined rodent electrodes. Finally, we demonstrate acute measurements of dopamine release in the caudate of a human patient during DBS electrode implantation surgery. The data generated are highly amenable for future work investigating the relationship between dopamine levels and important decision variables in human decisionmaking tasks.