Browsing by Author "Singh, Jasvinder A."

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    Burden of lower respiratory infections in the Eastern Mediterranean Region between 1990 and 2015: findings from the Global Burden of Disease 2015 study
    Mokdad, Ali H.; Moradi-Lakeh, Maziar; El Bcheraoui, Charbel; Charara, Raghid; Khalil, Ibrahim; Afshin, Ashkan; Kassebaum, Nicholas J.; Collison, Michael; Daoud, Farah; Chew, Adrienne; Krohn, Kristopher J.; Colombara, Danny; Ehrenkranz, Rebecca; Foreman, Kyle J.; Frostad, Joseph; Godwin, William W.; Kutz, Michael; Rao, Puja C.; Reiner, Robert; Troeger, Christopher; Wang, Haidong; Abajobir, Amanuel Alemu; Abbas, Kaja M.; Abera, Semaw Ferede; Abu-Raddad, Laith J.; Adane, Kelemework; Kiadaliri, Aliasghar Ahmad; Ahmadi, Alireza; Beshir, Muktar; Al-Eyadhy, Ayman; Alam, Khurshid; Alam, Noore; Alasfoor, Deena; Alizadeh-Navaei, Reza; Al-Maskari, Fatma; Al-Raddadi, Rajaa; Alsharif, Ubai; Altirkawi, Khalid A.; Anber, Nahla; Ansari, Hossein; Antonio, Carl Abelardo T.; Anwari, Palwasha; Asayesh, Hamid; Asgedom, Solomon Weldegebreal; Atey, Tesfay Mehari; Arthur, Euripide Frinel G.; Bacha, Umar; Barac, Aleksandra; Bazargan-Hejazi, Shahrzad; Drew, Charles R.; Geffen, David; Bedi, Neeraj; Bhutta, Zulfiqar A.; Michael, Brauer; Butt, Zahid A.; Castañeda-Orjuela, Carlos A.; Danawi, Hadi; Djalalinia, Shirin; Endries, Aman Yesuf; Eshrati, Babak; Farvid, Maryam S.; Fereshtehnejad, Seyed-Mohammad; Fischer, Florian; Garcia-Basteiro, Alberto L.; Gebrehiwot, Kiros Tedla; Gebrehiwot, Tsegaye Tewelde; Hailu, Gessessew Bugssa; Hamadeh, Randah Ribhi; Hambisa, Mitiku Teshome; Hamidi, Samer; Hassanvand, Mohammad Sadegh; Hedayati, Mohammad T.; Horita, Nobuyuki; Husseini, Abdullatif; Spencer, Lewis James; Javanbakht, Mehdi; Jonas, Jost B.; Kasaeian, Amir; Khader, Yousef Saleh; Khan, Ejaz Ahmad; Khan, Gulfaraz; Khoja, Abdullah Tawfih Abdullah; Khubchandani, Jagdish; Kim, Yun Jin; Kissoon, Niranjan; Larson, Heidi J.; Latif, Asma Abdul; Leshargie, Cheru Tesema; Lunevicius, Raimundas; Abd El Razek, Hassan Magdy; Abd El Razek, Mohammed Magdy; Majdzadeh, Reza; Majeed, Azeem; Malekzadeh, Reza; Farid, Habibolah Masoudi; Mehari, Alem; Memish, Ziad A.; Mengistu, Desalegn Tadese; Mensah, George A.; Mezgebe, Haftay Berhane; Nakamura, Sachiko; Oren, Eyal; Pourmalek, Farshad; Qorbani, Mostafa; Radfar, Amir; Rafay, Anwar; Rahimi-Movaghar, Vafa; Rai, Rajesh Kumar; Rawaf, David Laith; Rawaf, Salman; Refaat, Amany H.; Rezaei, Satar; Rezai, Mohammad Sadegh; Roba, Hirbo Shore; Roshandel, Gholamreza; Safdarian, Mahdi; Safiri, Saeid; Sahraian, Mohammad Ali; Salamati, Payman; Samy, Abdallah M.; Sartorius, Benn; Sepanlou, Sadaf G.; Shaikh, Masood Ali; Shamsizadeh, Morteza; Shigematsu, Mika; Singh, Jasvinder A.; Sufiyan, Muawiyyah Babale; Tehrani-Banihashemi, Arash; Temsah, Mohamad-Hani; Topor-Madry, Roman; Uthman, Olalekan A.; Vollset, Stein Emil; Wakayo, Tolassa; Werdecker, Andrea; Wijeratne, Tissa; Yaghoubi, Mohsen; Yimam, Hassen Hamid; Yonemoto, Naohiro; Younis, Mustafa Z.; Zaki, Maysaa El Sayed; Jumaan, Aisha O.; Vos, Theo; Naghavi, Mohsen; Hay, Simon I.; Murray, Christopher J. L. (2018-05)
    We used data from the Global Burden of Disease 2015 study (GBD) to calculate the burden of lower respiratory infections (LRIs) in the 22 countries of the Eastern Mediterranean Region (EMR) from 1990 to 2015. We conducted a systematic analysis of mortality and morbidity data for LRI and its specific etiologic factors, including pneumococcus, Haemophilus influenzae type b, Respiratory syncytial virus, and influenza virus. We used modeling methods to estimate incidence, deaths, and disability-adjusted life-years (DALYs). We calculated burden attributable to known risk factors for LRI. In 2015, LRIs were the fourth-leading cause of DALYs, causing 11,098,243 (95% UI 9,857,095-12,396,566) DALYs and 191,114 (95% UI 170,934-210,705) deaths. The LRI DALY rates were higher than global estimates in 2015. The highest and lowest age-standardized rates of DALYs were observed in Somalia and Lebanon, respectively. Undernutrition in childhood and ambient particulate matter air pollution in the elderly were the main risk factors. Our findings call for public health strategies to reduce the level of risk factors in each age group, especially vulnerable child and elderly populations.
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    How often is the office visit needed? Predicting total knee arthroplasty revision risk using pain/function scores
    Hightower, Charles D.; Hightower, Lisa S.; Tatman, Penny J.; Morgan, Patrick M.; Gioe, Terence; Singh, Jasvinder A. (2016-08-24)
    Background Most patients have favorable outcomes after primary total knee arthroplasty (TKA). Well-validated methods to predict the risk of poor outcomes have not been developed or implemented. Several patients have annual clinic visits despite well-funcitoning TKA, as a routine practice, to detect early failure requiring revision surgery. It is not known whether assessment of pain and function can be used as a predictive tool for early failure and revision to guide practice. Our objective was to determine whether pain and function can predict revision after TKA. Methods We retrospectively studied data from a large prospectively gathered TKA registry to examine changes in outcome scores for primary TKAs undergoing revision compared to those not requiring revision to determine the factors that are predictive for revision. Results Of the 1,012 patients, 721 had had a single-sided primary TKA and had American Knee Society (AKS) Scores for three or more visits. 46 patients underwent revision, 23 acutely (fracture, traumatic component failure or acute infection) and 23 for latent causes (late implant loosening, progressive osteolysis, or pain and indolent infection). Mean age was 70 years for the non-revision patients, and 64 years for those revised. Both AKS Clinical and AKS Function Scores for non-revised patients were higher than in revision patients, higher in acute revision compared to latent revision patients. Significant predictors of revision surgery were preoperative, 3- and 15-month postoperative AKS Clinical Scores and 3-month AKS Function Scores. At 15-month post-TKA, a patient with a low calculated probability of revision, 32 % or less, was unlikely to require revision surgery with a negative predictive value of 99 %. Conclusion Time dependent interval evaluation post-TKA with the AKS outcome scores may provide the ability to assign risk of revision to patients at the 15-month follow-up visit. If these findings can be replicated using a patient-reported measure, a virtual follow-up with patient-reported outcomes and X-ray review may be an alternative to clinic visit for patients doing well.
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    Trends in HIV/AIDS morbidity and mortality in Eastern Mediterranean countries, 1990-2015: findings from the Global Burden of Disease 2015 study
    Mokdad, Ali H.; El Bcheraoui, Charbel; Wang, Haidong; Charara, Raghid; Khalil, Ibrahim; Moradi-Lakeh, Maziar; Afshin, Ashkan; Collison, Michael; Daoud, Farah; Chew, Adrienne; Krohn, Kristopher J.; Carter, Austin; Foreman, Kyle J.; He, Fei; Kassebaum, Nicholas J.; Kutz, Michael; Mirarefin, Mojde; Nguyen, Grant; Silpakit, Naris; Sligar, Amber; Abajobir, Amanuel Alemu; Abate, Kalkidan Hassen; Abbas, Kaja M.; Abd-Allah, Foad; Abera, Semaw Ferede; Adane, Kelemework; Agarwal, Arnav; Kiadaliri, Aliasghar Ahmad; Ahmadi, Alireza; Ahmed, Muktar Beshir; Al Lami, Faris Hasan; Alam, Khurshid; Alasfoor, Deena; Alizadeh-Navaei, Reza; Al-Maskari, Fatma; Al-Raddadi, Rajaa; Altirkawi, Khalid A.; Alvis-Guzman, Nelson; Ammar, Walid; Anber, Nahla; Antonio, Carl Abelardo T.; Anwari, Palwasha; Asayesh, Hamid; Asghar, Rana Jawad; Atey, Tesfay Mehari; Avokpaho, Euripide Frinel G. Arthur; Ayele, Tadesse Awoke; Azzopardi, Peter; Bacha, Umar; Barac, Aleksandra; Baernighausen, Till; Bazargan-Hejazi, Shahrzad; Geffen, David; Bedi, Neeraj; Bensenor, Isabela M.; Berhane, Adugnaw; Bessong, Pascal Obong; Beyene, Addisu Shunu; Bhutta, Zulfiqar A.; Birungi, Charles; Butt, Zahid A.; Cahuana-Hurtado, Lucero; Danawi, Hadi; das Neves, Jose; Deribe, Kebede; Deribew, Amare; Jarlais, Don C. Des; Dharmaratne, Samath D.; Djalalinia, Shirin; Doyle, Kerrie E.; Endries, Aman Yesuf; Eshrati, Babak; Faraon, Emerito Jose Aquino; Farvid, Maryam S.; Fereshtehnejad, Seyed-Mohammad; Feyissa, Tesfaye Regassa; Fischer, Florian; Garcia-Basteiro, Alberto L.; Gebrehiwot, Tsegaye Tewelde; Gesesew, Hailay Abrha; Gishu, Melkamu Dedefo; Glaser, Elizabeth; Gona, Philimon N.; Gugnani, Harish Chander; Gupta, Rahul; Bidgoli, Hassan Haghparast; Hailu, Gessessew Bugssa; Hamadeh, Randah Ribhi; Hambisa, Mitiku Teshome; Hamidi, Samer; Harb, Hilda L.; Hareri, Habtamu Abera; Horita, Nobuyuki; Husseini, Abdullatif; Ibrahim, Ahmed; James, Spencer Lewis; Jonas, Jost B.; Kasaeian, Amir; Kassaw, Nigussie Assefa; Khader, Yousef Saleh; Khan, Ejaz Ahmad; Khan, Gulfaraz; Khoja, Abdullah Tawfih Abdullah; Khubchandani, Jagdish; Kim, Yun Jin; Koyanagi, Ai; Defo, Barthelemy Kuate; Larson, Heidi J.; Latif, Asma Abdul; Leshargie, Cheru Tesema; Lunevicius, Raimundas; Abd El Razek, Mohammed Magdy; Majdzadeh, Reza; Majeed, Azeem; Malekzadeh, Reza; Manyazewal, Tsegahun; Markos, Desalegn; Farid, Habibolah Masoudi; Mehari, Alem; Mekonnen, Alemayehu B.; Memiah, Peter; Memish, Ziad A.; Mendoza, Walter; Mengesha, Melkamu Merid; Mengistu, Desalegn Tadese; Mezgebe, Haftay Berhane; Mhimbira, Francis Apolinary; Miller, Ted R.; Moore, Ami R.; Mumtaz, Ghina R.; Natarajan, Gopalakrishnan; Negin, Joel; Obermeyer, Carla Makhlouf; Ogbo, Felix Akpojene; Oh, In-Hwan; Ota, Erika; Pereira, David M.; Pourmalek, Farshad; Qorbani, Mostafa; Radfar, Amir; Rafay, Anwar; Rahimi-Movaghar, Vafa; Rai, Rajesh Kumar; Ram, Usha; Rawaf, David Laith; Rawaf, Salman; Renzaho, Andre M. N.; Rezaei, Satar; Rezai, Mohammad Sadegh; Roba, Hirbo Shore; Roshandel, Gholamreza; Safdarian, Mahdi; Safiri, Saeid; Sahraian, Mohammad Ali; Salamati, Payman; Samy, Abdallah M.; Sartorius, Benn; Sepanlou, Sadaf G.; Shaikh, Masood Ali; Shamsizadeh, Morteza; Sibamo, Ephrem Lejore Sibamo; Singh, Jasvinder A.; Sobaih, Badr H. A.; Soshnikov, Sergey; Sufiyan, Muawiyyah Babale; Sykes, Bryan L.; Taveira, Nuno; Tegegne, Teketo Kassaw; Tehrani-Banihashemi, Arash; Tekelab, Tesfalidet; Shifa, Girma Temam; Temsah, Mohamad-Hani; Tesssema, Belay; Topor-Madry, Roman; Ukwaja, Kingsley Nnanna; Uthman, Olalekan A.; Vollset, Stein Emil; Wadilo, Fiseha; Wakayo, Tolassa; Alebachew, Minyahil; Workicho, Abdulhalik; Workie, Shimelash Bitew; Yaghoubi, Mohsen; Yalew, Ayalnesh Zemene; Yimam, Hassen Hamid; Yonemoto, Naohiro; Yoon, Seok-Jun; Yotebieng, Marcel; Younis, Mustafa Z.; Zaki, Maysaa El Sayed; Jumaan, Aisha O.; Vos, Theo; Hay, Simon I.; Naghavi, Mohsen; Murray, Christopher J. L. (2018-05)
    We used the results of the Global Burden of Disease 2015 study to estimate trends of HIV/AIDS burden in Eastern Mediterranean Region (EMR) countries between 1990 and 2015. Tailored estimation methods were used to produce final estimates of mortality. Years of life lost (YLLs) were calculated by multiplying the mortality rate by population by age-specific life expectancy. Years lived with disability (YLDs) were computed as the prevalence of a sequela multiplied by its disability weight. In 2015, the rate of HIV/AIDS deaths in the EMR was 1.8 (1.4-2.5) per 100,000 population, a 43% increase from 1990 (0.3; 0.2-0.8). Consequently, the rate of YLLs due to HIV/AIDS increased from 15.3 (7.6-36.2) per 100,000 in 1990 to 81.9 (65.3-114.4) in 2015. The rate of YLDs increased from 1.3 (0.6-3.1) in 1990 to 4.4 (2.7-6.6) in 2015. HIV/AIDS morbidity and mortality increased in the EMR since 1990. To reverse this trend and achieve epidemic control, EMR countries should strengthen HIV surveillance, and scale up HIV antiretroviral therapy and comprehensive prevention services.