Browsing by Author "Singh, Vivek"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming
    Rahmanto, Yohan Suryo; Shen, Wenjing; Shi, Xu; Chen, Xi; Yu, Yu; Yu, Zheng-Cheng; Miyamoto, Tsutomu; Lee, Meng-Horng; Singh, Vivek; Asaka, Ryoichi; Shimberg, Geoffrey; Vitolo, Michele, I.; Martin, Stuart S.; Wirtz, Denis; Drapkin, Ronny; Xuan, Jianhua; Wang, Tian-Li; Shih, Ie-Ming (2020-06-01)
    Somatic inactivating mutations of ARID1A, a SWI/SNF chromatin remodeling gene, are prevalent in human endometrium-related malignancies. To elucidate the mechanisms underlying how ARID1A deleterious mutation contributes to tumorigenesis, we establish genetically engineered murine models with Arid1a and/or Pten conditional deletion in the endometrium. Transcriptomic analyses on endometrial cancers and precursors derived from these mouse models show a close resemblance to human uterine endometrioid carcinomas. We identify transcriptional networks that are controlled by Arid1a and have an impact on endometrial tumor development. To verify findings from the murine models, we analyze ARID1A(WT) and ARID1A(KO) human endometrial epithelial cells. Using a system biology approach and functional studies, we demonstrate that ARID1A-deficiency lead to loss of TGF-beta tumor suppressive function and that inactivation of ARID1A/TGF-beta axis promotes migration and invasion of PTEN-deleted endometrial tumor cells. These findings provide molecular insights into how ARID1A inactivation accelerates endometrial tumor progression and dissemination, the major causes of cancer mortality.
  • Thumbnail Image
    Results from the Cuore Experiment
    Caminata, Alessio; Adams, Douglas; Alduino, Chris; Alfonso, Krystal; Avignone, Frank; Azzolini, Oscar; Bari, Giacomo; Bellini, Fabio; Benato, Giovanni; Bersani, Andrea; Biassoni, Matteo; Branca, Antonio; Brofferio, Chiara; Bucci, Carlo; Campani, Alice; Canonica, Lucia; Cao, Xi-Guang; Capelli, Silvia; Cappelli, Luigi; Cardani, Laura; Carniti, Paolo; Casali, Nicola; Chiesa, Davide; Chott, Nicholas; Clemenza, Massimiliano; Copello, Simone; Cosmelli, Carlo; Cremonesi, Oliviero; Creswick, Richard; Cushman, Jeremy; D’Addabbo, Antonio; D’Aguanno, Damiano; Dafinei, Ioan; Davis, Christopher; Dell’Oro, Stefano; Deninno, Milena; Di Domizio, Sergio; Dompè, Valentina; Drobizhev, Alexey; Fang, De-Qing; Fantini, Guido; Faverzani, Marco; Ferri, Elena; Ferroni, Fernando; Fiorini, Ettore; Franceschi, Massimo Alberto; Freedman, Stuart; Fujikawa, Brian; Giachero, Andrea; Gironi, Luca; Giuliani, Andrea; Gorla, Paolo; Gotti, Claudio; Gutierrez, Thomas; Han, Ke; Heeger, Karsten; Hennings-Yeomans, Raul; Huang, Roger; Huang, Huan Zhong; Johnston, Joe; Keppel, Giorgio; Kolomensky, Yury; Leder, Alexander; Ligi, Carlo; Ma, Yu-Gang; Marini, Laura; Martinez, Maria; Maruyama, Reina; Mei, Yuan; Moggi, Niccolo; Morganti, Silvio; Napolitano, Tommaso; Nastasi, Massimiliano; Nones, Claudia; Norman, Eric; Novati, Valentina; Nucciotti, Angelo; Nutini, Irene; O’Donnell, Thomas; Ouellet, Jonathan; Pagliarone, Carmine; Pallavicini, Marco; Pattavina, Luca; Pavan, Maura; Pessina, Gianluigi; Pettinacci, Valerio; Pira, Cristian; Pirro, Stefano; Pozzi, Stefano; Previtali, Ezio; Puiu, Andrei; Rosenfeld, Carl; Rusconi, Claudia; Sakai, Michinari; Sangiorgio, Samuele; Schmidt, Benjamin; Scielzo, Nick; Singh, Vivek; Sisti, Monica; Speller, Danielle; Taffarello, Luca; Terranova, Francesco; Tomei, Claudia; Vignati, Marco; Wagaarachchi, Sachinthya; Wang, Barbara; Welliver, Bradford; Wilson, Jeffrey; Wilson, Kevin; Winslow, Lindley; Wise, Tom; Zanotti, Luigi; Zimmermann, Sergio; Zucchelli, Stefano (MDPI, 2019-01-02)
    The Cryogenic Underground Observatory for Rare Events (CUORE) is the first bolometric experiment searching for neutrinoless double beta decay that has been able to reach the 1-ton scale. The detector consists of an array of 988 TeO 2 crystals arranged in a cylindrical compact structure of 19 towers, each of them made of 52 crystals. The construction of the experiment was completed in August 2016 and the data taking started in spring 2017 after a period of commissioning and tests. In this work we present the neutrinoless double beta decay results of CUORE from examining a total TeO 2 exposure of 86.3 kg yr , characterized by an effective energy resolution of 7.7 keV FWHM and a background in the region of interest of 0.014 counts / ( keV kg yr ) . In this physics run, CUORE placed a lower limit on the decay half-life of neutrinoless double beta decay of 130 Te > 1.3 · 10 25 yr (90% C.L.). Moreover, an analysis of the background of the experiment is presented as well as the measurement of the 130 Te 2 ν β β decay with a resulting half-life of T 1 / 2 2 ν = [ 7.9 ± 0.1 ( stat . ) ± 0.2 ( syst . ) ] × 10 20 yr which is the most precise measurement of the half-life and compatible with previous results.