Browsing by Author "Srikanchana, Rujirutana"
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- Modeling and Reconstruction of Mixed Functional and Molecular PatternsWang, Yue; Xuan, Jianhua; Srikanchana, Rujirutana; Choyke, Peter L. (Hindawi, 2006-01-17)Functional medical imaging promises powerful tools for thevisualization and elucidation of important disease-causingbiological processes in living tissue. Recent research aims todissect the distribution or expression of multiple biomarkersassociated with disease progression or response, where the signalsoften represent a composite of more than one distinct sourceindependent of spatial resolution. Formulating the task as a blindsource separation or composite signal factorization problem, wereport here a statistically principled method for modeling andreconstruction of mixed functional or molecular patterns. Thecomputational algorithm is based on a latent variable model whoseparameters are estimated using clustered component analysis. Wedemonstrate the principle and performance of the approaches on thebreast cancer data sets acquired by dynamic contrast-enhancedmagnetic resonance imaging.