Browsing by Author "Tong, Yuxin"
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- Low-cost sensor-integrated 3D-printed personalized prosthetic hands for children with amniotic band syndrome: A case study in sensing pressure distribution on an anatomical human-machine interface (AHMI) using 3D-printed conformal electrode arraysTong, Yuxin; Kucukdeger, Ezgi; Halper, Justin; Cesewski, Ellen; Karakozoff, Elena; Haring, Alexander P.; McIlvain, David; Singh, Manjot; Khandelwal, Nikita; Meholic, Alex; Laheri, Sahil; Sharma, Akshay; Johnson, Blake N. (PLOS, 2019)Interfacing anatomically conformal electronic components, such as sensors, with biology is central to the creation of next-generation wearable systems for health care and human augmentation applications. Thus, there is a need to establish computer-aided design and manufacturing methods for producing personalized anatomically conformal systems, such as wearable devices and human-machine interfaces (HMIs). Here, we show that a three-dimensional (3D) scanning and 3D printing process enabled the design and fabrication of a sensor-integrated anatomical human-machine interface (AHMI) in the form of personalized prosthetic hands that contain anatomically conformal electrode arrays for children affected by amniotic band syndrome, a common birth defect. A methodology for identifying optimal scanning parameters was identified based on local and global metrics of registered point cloud data quality. This method identified an optimal rotational angle step size between adjacent 3D scans. The sensitivity of the optimization process to variations in organic shape (i.e., geometry) was examined by testing other anatomical structures, including a foot, an ear, and a porcine kidney. We found that personalization of the prosthetic interface increased the tissue-prosthesis contact area by 408% relative to the non-personalized devices. Conformal 3D printing of carbon nanotube-based polymer inks across the personalized AHMI facilitated the integration of electronic components, specifically, conformal sensor arrays for measuring the pressure distribution across the AHMI (i.e., the tissue-prosthesis interface). We found that the pressure across the AHMI exhibited a non-uniform distribution and became redistributed upon activation of the prosthetic hand's grasping action. Overall, this work shows that the integration of 3D scanning and 3D printing processes offers the ability to design and fabricate wearable systems that contain sensor-integrated AHMIs.
- Multi-material Non-planar Additive Manufacturing for Conformal Electronics on Curvilinear SurfacesTong, Yuxin (Virginia Tech, 2021-03-23)Non-planar additive manufacturing (AM) technologies, such as microextrusion 3D printing processes, offer the ability to fabricate conformal electronics with impressive structure and function on curvilinear substrates. Although various available methods offer conformal 3D printing capability on objects with limited geometric complexity, a number of challenges remain to improve feature resolution, throughput, materials compatibility, resultant function and properties of printed components, and application to substrates of varying topography. Hence, the overall objective of this dissertation was to create new non-planar AM processes that are compatible with personalized and anatomical computer-aided design workflows for the fabrication of conformal electronics and form-fitting wearables. After reviewing the current state of knowledge and state of the art, significant challenges in non-planar AM have been identified as: 1) limited non-planar AM path planning capability that synergizes with personalized or anatomical object surface modification, 2) limited approaches for printed and non-printed component integration on non-planar substrates. To address these challenges, a template-based reverse engineering workflow is proposed for conformal 3D printing electronics and form-fitting wearable devices on anatomical structures. This work was organized into three complementary tasks that enhance non-planar AM capabilities: 1) To achieve anatomical tissue-sensor integration, 3D scanning-based point cloud data acquisition and customized 3D printable conductive ink are proposed for capturing the topographical information of patient-specific malformations and integrating conformal sensing electronics across anatomical tissue-device interface. 2) To fabricate conformal antennas on flexible thin-film polymer substrates, a versatile method for microextrusion 3D printing of conformal antennas on thin film-based structures of random topography is proposed to control the ink deposition process across the curvilinear surfaces of freeform Kapton-based origami. 3) To simplify the fabrication process of form-fitting wearable devices with fiber-based form factors and self-powered capability, an innovative 3D printing process is proposed to achieve coaxial multi-material extrusion of metal-elastomer triboelectric fibers. By developing new advanced non-planar printing processes and conformal toolpath programming strategies, the utility of non-planar AM could be further expanded for fabricating various personalized implantable and wearable multi-functional systems, including novel 3D electronics. In summary, this work advances capability in additive manufacturing processes by providing new advances in multi-material extrusion processes and personalized device design and manufacturing workflows.
- Multiphysics Modeling Of Devices For Whole Organ Healthcare ApplicationsTong, Yuxin (Virginia Tech, 2017-06-12)In order to fully understand the functionality of conformal devices, it is critical to develop computational models built from engineered models of 3-dimensional objects. This thesis established a scanning procedure to engineering 3D digital model for whole organs, known as template engineering. The resultant scanning data enabled designing, manufacturing, and modeling of novel organ healthcare devices. Specifically, we applied template engineering and structured-light scanning techniques to capture the 3D topographical information for whole organ systems. Sequentially, we developed multiphysics models for understanding the device functionality, including the function of devices for microfluidic interface and whole organ mechanical stabilization.
- Therapeutic effects of peripherally administrated neural crest stem cells on pain and spinal cord changes after sciatic nerve transectionZhang, Yang; Xu, Xiang; Tong, Yuxin; Zhou, Xijie; Du, Jian; Choi, In Y.; Yue, Shouwei; Lee, Gabsang; Johnson, Blake N.; Jia, Xiaofeng (2021-03-15)Background Severe peripheral nerve injury significantly affects patients’ quality of life and induces neuropathic pain. Neural crest stem cells (NCSCs) exhibit several attractive characteristics for cell-based therapies following peripheral nerve injury. Here, we investigate the therapeutic effect of NCSC therapy and associated changes in the spinal cord in a sciatic nerve transection (SNT) model. Methods Complex sciatic nerve gap injuries in rats were repaired with cell-free and cell-laden nerve scaffolds for 12 weeks (scaffold and NCSC groups, respectively). Catwalk gait analysis was used to assess the motor function recovery. The mechanical withdrawal threshold and thermal withdrawal latency were used to assess the development of neuropathic pain. Activation of glial cells was examined by immunofluorescence analyses. Spinal levels of extracellular signal-regulated kinase (ERK), NF-κB P65, brain-derived neurotrophic factor (BDNF), growth-associated protein (GAP)-43, calcitonin gene-related peptide (CGRP), and inflammation factors were calculated by western blot analysis. Results Catwalk gait analysis showed that animals in the NCSC group exhibited a higher stand index and Max intensity At (%) relative to those that received the cell-free scaffold (scaffold group) (p < 0.05). The mechanical and thermal allodynia in the medial-plantar surface of the ipsilateral hind paw were significantly relieved in the NCSC group. Sunitinib (SNT)-induced upregulation of glial fibrillary acidic protein (GFAP) (astrocyte) and ionized calcium-binding adaptor molecule 1 (Iba-1) (microglia) in the ipsilateral L4–5 dorsal and ventral horn relative to the contralateral side. Immunofluorescence analyses revealed decreased astrocyte and microglia activation. Activation of ERK and NF-κB signals and expression of transient receptor potential vanilloid 1 (TRPV1) expression were downregulated. Conclusion NCSC-laden nerve scaffolds mitigated SNT-induced neuropathic pain and improved motor function recovery after sciatic nerve repair. NCSCs also protected the spinal cord from SNT-induced glial activation and central sensitization.