Browsing by Author "Wang, Aiping"
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- Impact of physical activity and sleep quality on quality of life of rural residents with and without a history of cancer: findings of the Day and Night StudyRafie, Carlin; Ning, Yi; Wang, Aiping; Gao, Xiang; Houlihan, Robert (Dove Press, 2018)Background: Lifestyle behaviors may impact quality of life (QoL) in cancer survivors. The impact of physical activity and sleep quality on QoL in rural cancer survivors has not been well studied, however. Methods: Individuals with and without a history of cancer were recruited from rural Virginia. We collected information on physical activity (PAL), sleep quality (psqi), and QoL (Short Form-36). Additional dimensions of physical activity and sleep were measured including ambient light exposure and sleep duration via Actiwatch2, and serum vitamin D and urine melatonin, which are markers of outdoor activity and sleep. Results: 124 cancer survivors and 48 cancer-free individuals enrolled in the study. Mean age was 59, with majority women (89%) and Caucasian (76%). Breast cancer was most common (72%), and mean time from diagnosis to the survey was 8.1 years. Survivors were more sedentary and had significantly worse sleep quality and physical and mental health, relative to cancer-free individuals (p<0.05l). Quality of sleep of survivors and those cancer-free was significantly associated with physical (r=-0.335,p<0.001; r=-0.340,p<0.049 ) and mental health (r=-0.406,p=<0.001; r=-0.483,p<0.004) independent of age, gender, BMI, diabetes and CVD. In survivors, PAL was associated with physical and mental health (r=0.201,p=0.033; r=0.200,p=0.034), and outdoor activity was associated with mental health (r=0.271,p=0.005). Vitamin D3 was associated with physical health (rs=0.238, p=0.010) and outdoor activity (rs=0.236, p=0.012) in survivors. No association was found between melatonin, sleep quality or QoL. Physical activity, sleep quality, cancer status, BMI, and diabetes were predictive of physical health while physical activity and sleep quality were predictive of mental health. Conclusion: Quality of sleep and physical activity are significant predictors of mental and physical health in cancer survivors. Outdoor activity should be encouraged to improve mental health and vitamin D status. Sleep and outdoor activity interventions should have special consideration in rural cancer survivor care planning.
- An olive-derived elenolic acid stimulates hormone release from L-cells and exerts potent beneficial metabolic effects in obese diabetic miceWang, Yao; Wu, Yajun; Wang, Aiping; Wang, Aihua; Alkhalidy, Hana; Helm, Richard; Zhang, Shijun; Ma, Hongguang; Zhang, Yan; Gilbert, Elizabeth R.; Xu, Bin; Liu, Dongmin (Frontiers, 2022-11-01)Insulin resistance and progressive decline in functional β-cell mass are two key factors for developing type 2 diabetes (T2D), which is largely driven by overweight and obesity, a significant obstacle for effective metabolic control in many patients with T2D. Thus, agents that simultaneously ameliorate obesity and act on multiple pathophysiological components could be more effective for treating T2D. Here, we report that elenolic acid (EA), a phytochemical, is such a dual-action agent. we show that EA dose-dependently stimulates GLP-1 secretion in mouse clonal L-cells and isolated mouse ileum crypts. In addition, EA induces L-cells to secrete peptide YY (PYY). EA induces a rapid increase in intracellular [Ca2+]i and the production of inositol trisphosphate in L-cells, indicating that EA activates phospholipase C (PLC)-mediated signaling. Consistently, inhibition of (PLC) or Gαq ablates EA-stimulated increase of [Ca2+]i and GLP-1 secretion. In vivo, a single dose of EA acutely stimulates GLP-1 and PYY secretion in mice, accompanied with an improved glucose tolerance and insulin levels. Oral administration of EA at a dose of 50 mg/kg/day for 2 weeks normalized the fasting blood glucose and restored glucose tolerance in high-fat diet-induced obese (DIO) mice to levels that were comparable to chow-fed mice. In addition, EA suppresses appetite, reduces food intake, promotes weight loss, and reverses perturbated metabolic variables in obese mice. These results suggest that EA could be a dual-action agent as an alternative or adjuvant treatment for both T2D and obesity.