Browsing by Author "Wu, Chaochen"
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- Molecular basis of 5-hydroxytryptophan synthesis in Saccharomyces cerevisiaeZhang, Jiantao; Wu, Chaochen; Sheng, Jiayuan; Feng, Xueyang (Royal Society of Chemistry, 2016-03-18)We report for the first time that 5-hydroxytryptophan can be synthesized in Saccharomyces cerevisiae by heterologously expressing prokaryotic phenylalanine 4-hydroxylase or eukaryotic tryptophan 3/5-hydroxylase, together with enhanced synthesis of MH4 or BH4 cofactors. The innate DFR1 gene in the folate synthesis pathway was found to play pivotal roles in 5-hydroxytryptophan synthesis.