Browsing by Author "Xiao, Qian"

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    Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice
    Zhou, Xinyi; Wu, Bifeng; Liu, Wenhao; Xiao, Qian; He, Wei; Zhou, Ying; Wei, Pengfei; Zhang, Xu; Liu, Yue; Wang, Jie; He, Jufang; Zhang, Zhigang; Li, Weidong; Wang, Liping; Tu, Jie (2021-06-18)
    A strong animal survival instinct is to approach objects and situations that are of benefit and to avoid risk. In humans, a large proportion of mental disorders are accompanied by impairments in risk avoidance. One of the most important genes involved in mental disorders is disrupted-in-schizophrenia-1 (DISC1), and animal models in which this gene has some level of dysfunction show emotion-related impairments. However, it is not known whether DISC1 mouse models have an impairment in avoiding potential risks. In the present study, we used DISC1-N terminal truncation (DISC1-N-TM) mice to investigate risk avoidance and found that these mice were impaired in risk avoidance on the elevated plus maze (EPM) and showed reduced social preference in a three-chamber social interaction test. Following EPM tests, c-Fos expression levels indicated that the nucleus accumbens (NAc) was associated with risk-avoidance behavior in DISC1-N-TM mice. In addition, in vivo electrophysiological recordings following tamoxifen administration showed that the firing rates of fast-spiking neurons (FS) in the NAc were significantly lower in DISC1-N-TM mice than in wild-type (WT) mice. In addition, in vitro patch clamp recording revealed that the frequency of action potentials stimulated by current injection was lower in parvalbumin (PV) neurons in the NAc of DISC1-N-TM mice than in WT controls. The impairment of risk avoidance in DISC1-N-TM mice was rescued using optogenetic tools that activated NAcPV neurons. Finally, inhibition of the activity of NAcPV neurons in PV-Cre mice mimicked the risk-avoidance impairment found in DISC1-N-TM mice during tests on the elevated zero maze. Taken together, our findings confirm an impairment in risk avoidance in DISC1-N-TM mice and suggest that reduced excitability of NAcPV neurons is responsible.
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    Temperature Correction and Analysis of Pavement Skid Resistance Performance Based on RIOHTrack Full-Scale Track
    Wu, Jiangfeng; Wang, Xudong; Wang, Linbing; Zhang, Lei; Xiao, Qian; Yang, Hailu (MDPI, 2020-08-28)
    The pavement skid resistance performance index is one of the most important indexes to ensure driving safety. Based on the test data of RIOHTrack full-scale track, this paper analyzes the decay law of pavement skid resistance performance, including the sideway force coefficient (SFC), British pendulum number (BPN), mean texture depth measured by sand patch method (MTD) and sensor measured texture depth by laser method (SMTD), under different equivalent single axle load times (ESALs). The paper analyzes the influence of different methods and conditions on the different indicators and excavates the internal correlation of different pavement skid resistance performance indexes, aiming to improve the effectiveness and accuracy of pavement skid resistance performance detection. The shortcomings of the temperature correction method of BPN and SFC are verified, which cannot correct the skid resistance performance effectively in different temperatures. Based on the assumption that there is a sensitive range of temperature influence on skid resistance performance, a new temperature correction method of skid resistance performance index is proposed based on the Boltzmann model and equivalent temperature of the asphalt surface layer. It can truly reflect the decay law of skid resistance pavement performance. At the same time, the internal correlation between BPN and MTD indicators is analyzed. It is found that there is a linear growth law between two indexes whose correlation coefficient is 0.999, which provides a reference for the research of pavement skid resistance performance.