Browsing by Author "Zheng, George"

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    Service-based analysis of biological pathways
    Zheng, George; Bouguettaya, Athman (2009-10-01)
    Background Computer-based pathway discovery is concerned with two important objectives: pathway identification and analysis. Conventional mining and modeling approaches aimed at pathway discovery are often effective at achieving either objective, but not both. Such limitations can be effectively tackled leveraging a Web service-based modeling and mining approach. Results Inspired by molecular recognitions and drug discovery processes, we developed a Web service mining tool, named PathExplorer, to discover potentially interesting biological pathways linking service models of biological processes. The tool uses an innovative approach to identify useful pathways based on graph-based hints and service-based simulation verifying user's hypotheses. Conclusion Web service modeling of biological processes allows the easy access and invocation of these processes on the Web. Web service mining techniques described in this paper enable the discovery of biological pathways linking these process service models. Algorithms presented in this paper for automatically highlighting interesting subgraph within an identified pathway network enable the user to formulate hypothesis, which can be tested out using our simulation algorithm that are also described in this paper.
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    Web Service Mining
    Zheng, George (Virginia Tech, 2009-02-04)
    In this dissertation, we present a novel approach for Web service mining. Web service mining is a new research discipline. It is different from conventional top down service composition approaches that are driven by specific search criteria. Web service mining starts with no such criteria and aims at the discovery of interesting and useful compositions of existing Web services. Web service mining requires the study of three main research topics: semantic description of Web services, efficient bottom up composition of composable services, and interestingness and usefulness evaluation of composed services. We first propose a Web service ontology to describe and organize the constructs of a Web service. We introduce the concept of Web service operation interface for the description of shared Web service capabilities and use Web service domains for grouping Web service capabilities based on these interfaces. We take clues from how Nature solves the problem of molecular composition and introduce the notion of Web service recognition to help devise efficient bottom up service composition strategies. We introduce several service recognition mechanisms that take advantage of the domain-based categorization of Web service capabilities and ontology-based description of operation semantics. We take clues from the drug discovery process and propose a Web service mining framework to group relevant mining activities into a progression of phases that would lead to the eventual discovery of useful compositions. Based on the composition strategies that are derived from recognition mechanisms, we propose a set of algorithms in the screening phase of the framework to automatically identify leads of service compositions. We propose objective interestingness and usefulness measures in the evaluation phase to narrow down the pool of composition leads for further exploration. To demonstrate the effectiveness of our framework and to address challenges faced by existing biological data representation methodologies, we have applied relevant techniques presented in this dissertation to the field of biological pathway discovery.