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Scholarly Works, School of Neuroscience

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https://hdl.handle.net/10919/84996
Research articles, presentations, and other scholarship

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Browsing Scholarly Works, School of Neuroscience by Department "Population Health Sciences"

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    Building Interdisciplinary Partnerships for Community-Engaged Environmental Health Research in Appalachian Virginia
    Satterwhite, Emily M.; Bell, Shannon E.; Marr, Linsey C.; Thompson, Christopher K.; Prussin, Aaron J. II; Buttling, Lauren G.; Pan, Jin; Gohlke, Julia M. (MDPI, 2020-03-05)
    This article describes a collaboration among a group of university faculty, undergraduate students, local governments, local residents, and U.S. Army staff to address long-standing concerns about the environmental health effects of an Army ammunition plant. The authors describe community-responsive scientific pilot studies that examined potential environmental contamination and a related undergraduate research course that documented residents’ concerns, contextualized those concerns, and developed recommendations. We make a case for the value of resource-intensive university–community partnerships that promote the production of knowledge through collaborations across disciplinary paradigms (natural/physical sciences, social sciences, health sciences, and humanities) in response to questions raised by local residents. Our experience also suggests that enacting this type of research through a university class may help promote researchers’ adoption of “epistemological pluralism”, and thereby facilitate the movement of a study from being “multidisciplinary” to “transdisciplinary”.
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    Zika Virus Persistently and Productively Infects Primary Adult Sensory Neurons In Vitro
    Swartwout, Brianna K.; Zlotnick, Marta G.; Saver, Ashley E.; McKenna, Caroline M.; Bertke, Andrea S. (MDPI, 2017-10-13)
    Zika virus (ZIKV) has recently surged in human populations, causing an increase in congenital and Guillain-Barré syndromes. While sexual transmission and presence of ZIKV in urine, semen, vaginal secretions, and saliva have been established, the origin of persistent virus shedding into biological secretions is not clear. Using a primary adult murine neuronal culture model, we have determined that ZIKV persistently and productively infects sensory neurons of the trigeminal and dorsal root ganglia, which innervate glands and mucosa of the face and the genitourinary tract, respectively, without apparent injury. Autonomic neurons that innervate these regions are not permissive for infection. However, productive ZIKV infection of satellite glial cells that surround and support sensory and autonomic neurons in peripheral ganglia results in their destruction. Persistent infection of sensory neurons, without affecting their viability, provides a potential reservoir for viral shedding in biological secretions for extended periods of time after infection. Furthermore, viral destruction of satellite glial cells may contribute to the development of Guillain-Barré Syndrome via an alternative mechanism to the established autoimmune response.