Strategic Growth Areas (SGAs)
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Similar to Destination Areas in structure, Strategic Growth Areas are smaller and aim for regional or national leadership. Strategic Growth Areas represent additional areas of strength, identified by a faculty survey conducted in January 2016. SGAs may mature into Destination Areas.
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Browsing Strategic Growth Areas (SGAs) by Department "Biomedical Engineering and Mechanics"
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- Dynamic Analysis and Design Optimization of a Drag-Based Vibratory SwimmerTahmasian, Sevak; Jafaryzad, Arsam; Bulzoni, Nicolas L.; Staples, Anne E. (MDPI, 2020-03-22)Many organisms achieve locomotion via reciprocal motions. This paper presents the dynamic analysis and design optimization of a vibratory swimmer with asymmetric drag forces and fluid added mass. The swimmer consists of a floating body with an oscillatory mass inside. One-dimensional oscillations of the mass cause the body to oscillate with the same frequency as the mass. An asymmetric rigid fin attached to the bottom of the body generates asymmetric hydrodynamic forces, which drive the swimmer either backward or forward on average, depending on the orientation of the fin. The equation of motion of the system is a time-periodic, piecewise-smooth differential equation. We use simulations to determine the hydrodynamic forces acting on the fin and averaging techniques to determine the dynamic response of the swimmer. The analytical results are found to be in good agreement with vibratory swimmer prototype experiments. We found that the average unidirectional speed of the swimmer is optimized if the ratio of the forward and backward drag coefficients is minimized. The analysis presented here can aid in the design and optimization of bio-inspired and biomimetic robotic swimmers. A magnetically controlled microscale vibratory swimmer like the one described here could have applications in targeted drug delivery.
- Focused ultrasound actuation of shape memory polymers; acoustic-thermoelastic modeling and testingBhargava, Aarushi; Peng, Kaiyuan; Stieg, Jerry; Mirzaeifar, Reza; Shahab, Shima (The Royal Society of Chemistry, 2017-09-18)Controlled drug delivery (CDD) technologies have received extensive attention recently. Despite recent efforts, drug releasing systems still face major challenges in practice, including low efficiency in releasing the pharmaceutical compounds at the targeted location with a controlled time rate. We present an experimentally-validated acoustic-thermoelastic mathematical framework for modeling the focused ultrasound (FU)-induced thermal actuation of shape memory polymers (SMPs). This paper also investigates the feasibility of using SMPs stimulated by FU for designing CDD systems. SMPs represent a new class of materials that have gained increased attention for designing biocompatible devices. These polymers have the ability of storing a temporary shape and returning to their permanent or original shape when subjected to external stimuli such as heat. In this work, FU is used as a trigger for noninvasively stimulating SMP-based systems. FU has a superior capability to localize the heating effect, thus initiating the shape recovery process only in selected parts of the polymer. The multiphysics model optimizes the design of a SMP-based CDD system through analysis of a filament as a constituting basestructure and quantifies its activation under FU. Experimental validations are performed using a SMP filament submerged in water coupled with the acoustic waves generated by a FU transducer. The modeling results are used to examine and optimize parameters such as medium properties, input power and frequency, location, geometry and chemical composition of the SMP to achieve favorable shape recovery of a potential drug delivery system.
- Folic Acid-Conjugated Cellulose Nanocrystals Show High Folate-Receptor Binding Affinity and Uptake by KB and Breast Cancer CellsBittleman, Katelyn Rose; Dong, Shuping; Roman, Maren; Lee, Yong Woo (American Chemical Society, 2018-10-24)The study evaluates cellulose nanocrystals (CNCs) as nanocarriers for targeted, intracellular delivery of molecular agents. CNCs were labeled with fluorescein-5′-isothiocyanate as an imaging agent and conjugated to folic acid (FA) as a targeting ligand. The CNC conjugates were characterized by UV–vis spectroscopy, ζ-potential analysis, dynamic light scattering, and atomic force microscopy. Cellular binding/uptake of the FA-conjugated CNCs by KB and MDA-MB-468 cells was quantified with cellular uptake assays. Internalization of the particles was confirmed by confocal microscopy. Uptake mechanisms were determined by inhibition studies with chlorpromazine and genistein. Binding affinity was qualitatively assessed with a free folate inhibition assay. Both KB and MDA-MB-468 cells exhibited significant and folate-receptor specific binding/uptake of FA-conjugated CNCs. Clathrin-mediated endocytosis was a significant uptake mechanism in both cell types, whereas caveolae-mediated endocytosis only played a significant role in MDA-MB-468 cells. Uptake inhibition of FA-conjugated CNCs by KB cells required high concentrations (>1 mM) of free FA. The observed FR-specific internalization of FA-conjugated CNCs by FR-positive cancer cells and tumors and their remarkable high affinity for the FR demonstrate the great potential of CNCs as novel nanocarriers for imaging agents and chemotherapeutics in the early detection and treatment of cancer.
- Immersion Bioprinting of Tumor Organoids in Multi-Well Plates for Increasing Chemotherapy Screening ThroughputMaloney, Erin; Clark, Casey; Sivakumar, Hemamylammal; Yoo, KyungMin; Aleman, Julio; Rajan, Shiny A. P.; Forsythe, Steven; Mazzocchi, Andrea R.; Laxton, Adrian W.; Tatter, Stephen B.; Strowd, Roy E.; Votanopoulos, Konstantinos I.; Skardal, Aleksander (MDPI, 2020-02-18)The current drug development pipeline takes approximately fifteen years and $2.6 billion to get a new drug to market. Typically, drugs are tested on two-dimensional (2D) cell cultures and animal models to estimate their efficacy before reaching human trials. However, these models are often not representative of the human body. The 2D culture changes the morphology and physiology of cells, and animal models often have a vastly different anatomy and physiology than humans. The use of bioengineered human cell-based organoids may increase the probability of success during human trials by providing human-specific preclinical data. They could also be deployed for personalized medicine diagnostics to optimize therapies in diseases such as cancer. However, one limitation in employing organoids in drug screening has been the difficulty in creating large numbers of homogeneous organoids in form factors compatible with high-throughput screening (e.g., 96- and 384-well plates). Bioprinting can be used to scale up deposition of such organoids and tissue constructs. Unfortunately, it has been challenging to 3D print hydrogel bioinks into small-sized wells due to well–bioink interactions that can result in bioinks spreading out and wetting the well surface instead of maintaining a spherical form. Here, we demonstrate an immersion printing technique to bioprint tissue organoids in 96-well plates to increase the throughput of 3D drug screening. A hydrogel bioink comprised of hyaluronic acid and collagen is bioprinted into a viscous gelatin bath, which blocks the bioink from interacting with the well walls and provides support to maintain a spherical form. This method was validated using several cancerous cell lines, and then applied to patient-derived glioblastoma (GBM) and sarcoma biospecimens for drug screening.
- Interactional dynamics of same-sex marriage legislation in the United StatesRoy, Subhradeep; Abaid, Nicole (The Royal Society, 2017)Understanding how people form opinions and make decisions is a complex phenomenon that depends on both personal practices and interactions. Recent availability of real-world data has enabled quantitative analysis of opinion formation, which illuminates phenomena that impact physical and social sciences. Public policies exemplify complex opinion formation spanning individual and population scales, and a timely example is the legalization of same-sex marriage in the United States. Here, we seek to understand how this issue captures the relationship between state-laws and Senate representatives subject to geographical and ideological factors. Using distancebased correlations, we study how physical proximity and stategovernment ideology may be used to extract patterns in statelaw adoption and senatorial support of same-sex marriage. Results demonstrate that proximal states have similar opinion dynamics in both state-laws and senators’ opinions, and states with similar state-government ideology have analogous senators’ opinions. Moreover, senators’ opinions drive statelaws with a time lag. Thus, change in opinion not only results from negotiations among individuals, but also reflects inherent spatial and political similarities and temporal delays. We build a social impact model of state-law adoption in light of these results, which predicts the evolution of state-laws legalizing same-sex marriage over the last three decades.
- Oil-Impregnated Hydrocarbon-Based Polymer FilmsMukherjee, Ranit; Habibi, Mohammad; Rashed, Ziad T.; Berbert, Otacilio; Shi, Xiangke; Boreyko, Jonathan B. (Springer Nature, 2018-08-03)Porous surfaces impregnated with a liquid lubricant exhibit minimal contact angle hysteresis with immiscible test liquids, rendering them ideal as self-cleaning materials. Rather than roughening a solid substrate, an increasingly popular choice is to use an absorbent polymer as the "porous" material. However, to date the polymer choices have been limited to expensive silicone-based polymers or complex assemblies of polymer multilayers on functionalized surfaces. In this paper, we show that hydrocarbon-based polymer films such as polyethylene can be stably impregnated with chemically compatible vegetable oils, without requiring any surface treatment. These oil-impregnated hydrocarbon-based films exhibit minimal contact angle hysteresis for a wide variety of test products including water, ketchup, and yogurt. Our oil-impregnated films remain slippery even after several weeks of being submerged in ketchup, illustrating their extreme durability. We expect that the simple and cost-effective nature of our slippery hydrocarbon-based films will make them useful for industrial packaging applications.
- Perspective on Translating Biomaterials Into Glioma Therapy: Lessons From in Vitro ModelsCornelison, R. Chase; Munson, Jennifer M. (Frontiers, 2018-05-09)Glioblastoma (GBM) is the most common and malignant form of brain cancer. Even with aggressive standard of care, GBM almost always recurs because its diffuse, infiltrative nature makes these tumors difficult to treat. The use of biomaterials is one strategy that has been, and is being, employed to study and overcome recurrence. Biomaterials have been used in GBM in two ways: in vitro as mediums in which to model the tumor microenvironment, and in vivo to sustain release of cytotoxic therapeutics. In vitro systems are a useful platform for studying the effects of drugs and tissue-level effectors on tumor cells in a physiologically relevant context. These systems have aided examination of how glioma cells respond to a variety of natural, synthetic, and semi-synthetic biomaterials with varying substrate properties, biochemical factor presentations, and non-malignant parenchymal cell compositions in both 2D and 3D environments. The current in vivo paradigm is completely different, however. Polymeric implants are simply used to line the post-surgical resection cavities and deliver secondary therapies, offering moderate impacts on survival. Instead, perhaps we can use the data generated from in vitro systems to design novel biomaterial-based treatments for GBM akin to a tissue engineering approach. Here we offer our perspective on the topic, summarizing how biomaterials have been used to identify facets of glioma biology in vitro and discussing the elements that show promise for translating these systems in vivo as new therapies for GBM.