Journals

Permanent URI for this community

https://hdl.handle.net/10919/8195

Browse

Now showing 1 - 20 of 55

Ablation outcome of irreversible electroporation on potato monitored by impedance spectrum under multi-electrode system
Zhao, Yajun; Liu, Hongmei; Bhonsle, Suyashree P.; Wang, Yilin; Davalos, Rafael V.; Yao, Chenguo (2018-09-20)
Background Irreversible electroporation (IRE) therapy relies on pulsed electric fields to non-thermally ablate cancerous tissue. Methods for evaluating IRE ablation in situ are critical to assessing treatment outcome. Analyzing changes in tissue impedance caused by electroporation has been proposed as a method for quantifying IRE ablation. In this paper, we assess the hypothesis that irreversible electroporation ablation outcome can be monitored using the impedance change measured by the electrode pairs not in use, getting more information about the ablation size in different directions. Methods Using a square four-electrode configuration, the two diagonal electrodes were used to electroporate potato tissue. Next, the impedance changes, before and after treatment, were measured from different electrode pairs and the impedance information was extracted by fitting the data to an equivalent circuit model. Finally, we correlated the change of impedance from various electrode pairs to the ablation geometry through the use of fitted functions; then these functions were used to predict the ablation size and compared to the numerical simulation results. Results The change in impedance from the electrodes used to apply pulses is larger and has higher deviation than the other electrode pairs. The ablation size and the change in resistance in the circuit model correlate with various linear functions. The coefficients of determination for the three functions are 0.8121, 0.8188 and 0.8691, respectively, showing satisfactory agreement. The functions can well predict the ablation size under different pulse numbers, and in some directions it did even better than the numerical simulation method, which used different electric field thresholds for different pulse numbers. Conclusions The relative change in tissue impedance measured from the non-energized electrodes can be used to assess ablation size during treatment with IRE according to linear functions.
Acceleration Feedback-Based Active and Semi-Active Seismic Response Control of Rail-Counterweight Systems of Elevators
Singh, Rildova; Singh, Mahendra P. (Hindawi, 2005-01-01)
Based on the observations in the past earthquake events, the traction elevators in buildings are known to be vulnerable to earthquake induced ground motions. Among several components of an elevator, the counterweight being heaviest is also known to be more susceptible than others. The inertial effects of the counterweight can overstress the guide rails on which it moves. Here we investigate to use the well-known acceleration feedback-based active and semi-active control methods to reduce stresses in the rails. The only way a control action can be applied to a moving counterweight-rail system is through a mass damper placed in the plane of the counterweight. For this, a part of the counterweight mass can be configured as a mass damper attached to a small actuator for an active scheme or to a magneto-rheological damper for a semi-active scheme. A comprehensive numerical study is conducted to evaluate the effectiveness of the proposed configuration of control system. It is observed that the two control schemes are effective in reducing the stress response by about 20 to 25% and improve the system fragility over a good range of seismic intensities.
Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes
Rahbar, Elaheh; Waits, Charlotte M. K.; Kirby, Edward H.; Miller, Leslie R.; Ainsworth, Hannah C.; Cui, Tao; Sergeant, Susan; Howard, Timothy D.; Langefeld, Carl D.; Chilton, Floyd H. (2018-04-06)
Background Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with circulating LC-PUFA levels. More recently, epigenetic modifications such as DNA methylation, particularly within the FADS cluster, have been shown to affect LC-PUFA levels. Our lab previously demonstrated strong associations of allele-specific methylation (ASM) between a single nucleotide polymorphism (SNP) rs174537 and CpG sites across the FADS region in human liver tissues. Given that epigenetic signatures are tissue-specific, we aimed to evaluate the methylation status and ASM associations between rs174537 and DNA methylation obtained from human saliva, CD4+ cells and total leukocytes derived from whole blood. The goals were to (1) determine if DNA methylation from these peripheral samples would display similar ASM trends as previously observed in human liver tissues and (2) evaluate the associations between DNA methylation and circulating LC-PUFAs. Results DNA methylation at six CpG sites spanning FADS1 and FADS2 promoter regions and a putative FADS enhancer region were determined in two Caucasian cohorts of healthy volunteers: leukocytes in cohort 1 (n = 89, median age = 43, 35% male) and saliva and CD4+ cells in cohort 2 (n = 32, median age = 41, 41% male). Significant ASM between rs174537 and DNA methylation at three CpG sites located in the FADS2 promoter region (i.e., chr11:61594865, chr11:61594876, chr11:61594907) and one CpG site in the putative enhancer region (chr11:61587979) were observed with leukocytes. In CD4+ cells, significant ASM was observed at CpG sites chr11:61594876 and chr11:61584894. Genotype at rs174537 was significantly associated with DNA methylation from leukocytes. Similar trends were observed with CD4+ cells, but not with saliva. DNA methylation from leukocytes and CD4+ cells also significantly correlated with circulating omega-6 LC-PUFAs. Conclusions We observed significant ASM between rs174537 and DNA methylation at key regulatory regions in the FADS region from leukocyte and CD4+ cells. DNA methylation from leukocytes also correlated with circulating omega-6 LC-PUFAs. These results support the use of peripheral whole blood samples, with leukocytes showing the most promise for future nutrigenomic studies evaluating epigenetic modifications affecting LC-PUFA biosynthesis in humans.
Anti-Swing Control of Gantry and Tower Cranes Using Fuzzy and Time-Delayed Feedback with Friction Compensation
Omar, Hanafy M.; Nayfeh, Ali H. (Hindawi, 2005-01-01)
We designed a feedback controller to automate crane operations by controlling the load position and its swing. First, a PD tracking controller is designed to follow a prescribed trajectory. Then, another controller is added to the control loop to damp the load swing. The anti-swing controller is designed based on two techniques: a time-delayed feedback of the load swing angle and an anti-swing fuzzy logic controller (FLC). The rules of the FLC are generated by mapping the performance of the time-delayed feedback controller. The same mapping method used for generating the rules can be applied to mimic the performance of an expert operator. The control algorithms were designed for gantry cranes and then extended to tower cranes by considering the coupling between the translational and rotational motions. Experimental results show that the controller is effective in reducing load oscillations and transferring the load in a reasonable time. To experimentally validate the theory, we had to compensate for friction. To this end, we estimated the friction and then applied a control action to cancel it. The friction force was estimated by assuming a mathematical model and then estimating the model coefficients using an off-line identification technique, the method of least squares (LS).
Assessment of Deep Partial Thickness Burn Treatment with Keratin Biomaterial Hydrogels in a Swine Model
Poranki, D.; Goodwin, C.; Van Dyke, M. (Hindawi, 2016-01-01)
Partial thickness burns can advance to full thickness after initial injury due to inadequate tissue perfusion and increased production of inflammatory cytokines, which has been referred to as burn wound progression. In previous work, we demonstrated that a keratin biomaterial hydrogel appeared to reduce burn wound progression. In the present study, we tested the hypothesis that a modified keratin hydrogel could reduce burn wound progression and speed healing. Standardized burn wounds were created in Yorkshire swine and treated within 30 minutes with keratin hydrogel (modified and unmodified), collagen hydrogel, or silver sulfadiazine (SSD). Digital images of each wound were taken for area measurements immediately prior to cleaning and dressing changes. Wound tissue was collected and assessed histologically at several time points. Wound area showed a significant difference between hydrogels and SSD groups, and rates of reepithelialization at early time points showed an increase when keratin treatment was used compared to both collagen and SSD. A linear regression model predicted a time to wound closure of approximately 25 days for keratin hydrogel while SSD treatment required 35 days. There appeared to be no measurable differences between the modified and unmodified formulations of keratin hydrogels.
Axisymmetric Natural Frequencies of Statically Loaded Annular Plates
Abdel-Rahman, Eihab M.; Faris, Waleed F.; Nayfeh, Ali H. (Hindawi, 2003-01-01)
We present a numerical procedure to solve the axisymmetric vibration problem of statically loaded annular plates. We use the von Kármán nonlinear plate model to account for large deformations and study the effect of static deflections on the natural frequencies and mode shapes for six combinations of boundary conditions. The shooting method is used to solve the resulting eigenvalue problem. Our results show that static deformations have a significant effect on the natural frequencies and small effect on the mode shapes of the plate. Further, the results show that the presence of in-plane stresses has a significant effect on the natural frequencies.
Blood Vessel Patterning on Retinal Astrocytes Requires Endothelial Flt-1 (VEGFR-1)
Chappell, John C.; Darden, Jordan; Payne, Laura Beth; Fink, Kathryn; Bautch, Victoria L. (MDPI, 2019-09-07)
Feedback mechanisms are critical components of many pro-angiogenic signaling pathways that keep vessel growth within a functional range. The Vascular Endothelial Growth Factor-A (VEGF-A) pathway utilizes the decoy VEGF-A receptor Flt-1 to provide negative feedback regulation of VEGF-A signaling. In this study, we investigated how the genetic loss of flt-1 differentially affects the branching complexity of vascular networks in tissues despite similar effects on endothelial sprouting. We selectively ablated flt-1 in the post-natal retina and found that maximum induction of flt-1 loss resulted in alterations in endothelial sprouting and filopodial extension, ultimately yielding hyper-branched networks in the absence of changes in retinal astrocyte architecture. The mosaic deletion of flt-1 revealed that sprouting endothelial cells flanked by flt-1⁻^/− regions of vasculature more extensively associated with underlying astrocytes and exhibited aberrant sprouting, independent of the tip cell genotype. Overall, our data support a model in which tissue patterning features, such as retinal astrocytes, integrate with flt-1-regulated angiogenic molecular and cellular mechanisms to yield optimal vessel patterning for a given tissue.
Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects
Prabhu, Raj K.; Begonia, Mark T.; Whittington, Wilburn R.; Murphy, Michael A.; Mao, Yuxiong; Liao, Jun; Williams, Lakiesha N.; Horstemeyer, Mark F.; Sheng, Jianping (MDPI, 2019-05-07)
Designing protective systems for the human head—and, hence, the brain—requires understanding the brain’s microstructural response to mechanical insults. We present the behavior of wet and dry porcine brain undergoing quasi-static and high strain rate mechanical deformations to unravel the effect of hydration on the brain’s biomechanics. Here, native ‘wet’ brain samples contained ~80% (mass/mass) water content and ‘dry’ brain samples contained ~0% (mass/mass) water content. First, the wet brain incurred a large initial peak stress that was not exhibited by the dry brain. Second, stress levels for the dry brain were greater than the wet brain. Third, the dry brain stress–strain behavior was characteristic of ductile materials with a yield point and work hardening; however, the wet brain showed a typical concave inflection that is often manifested by polymers. Finally, finite element analysis (FEA) of the brain’s high strain rate response for samples with various proportions of water and dry brain showed that water played a major role in the initial hardening trend. Therefore, hydration level plays a key role in brain tissue micromechanics, and the incorporation of this hydration effect on the brain’s mechanical response in simulated injury scenarios or virtual human-centric protective headgear design is essential.
Control of Limit Cycle Oscillations of a Two-Dimensional Aeroelastic System
Ghommem, Mehdi; Nayfeh, Ali H.; Hajj, Muhammad R. (Hindawi Publishing Corporation, 2010)
Linear and nonlinear static feedback controls are implemented on a nonlinear aeroelastic system that consists of a rigid airfoil supported by nonlinear springs in the pitch and plunge directions and subjected to nonlinear aerodynamic loads. The normal form is used to investigate the Hopf bifurcation that occurs as the freestream velocity is increased and to analytically predict the amplitude and frequency of the ensuing limit cycle oscillations (LCO). It is shown that linear control can be used to delay the flutter onset and reduce the LCO amplitude. Yet, its required gains remain a function of the speed. On the other hand, nonlinear control can be efficiently implemented to convert any subcritical Hopf bifurcation into a supercritical one and to significantly reduce the LCO amplitude.
Control of Rotary Cranes Using Fuzzy Logic
Al-mousa, Amjed A.; Nayfeh, Ali H.; Kachroo, Pushkin (Hindawi, 2003-01-01)
Rotary cranes (tower cranes) are common industrial structures that are used in building construction, factories, and harbors. These cranes are usually operated manually. With the size of these cranes becoming larger and the motion expected to be faster, the process of controlling them has become difficult without using automatic control methods. In general, the movement of cranes has no prescribed path. Cranes have to be run under different operating conditions, which makes closed-loop control attractive.In this work a fuzzy logic controller is introduced with the idea of “split-horizon”; that is, fuzzy inference engines (FIE) are used for tracking the position and others are used for damping the load oscillations. The controller consists of two independent sub-controllers: radial and rotational. Each of these controllers has two fuzzy inference engines (FIE). Computer simulations are used to verify the performance of the controller. Three simulation cases are presented. In the first case, the crane is operated in the gantry (radial) mode in which the trolley moves along the jib while the jib is fixed. In the second case (rotary mode), the trolley moves along the jib and the jib rotates. In the third case, the trolley and jib are fixed while the load is given an initial disturbance. The results from the simulations show that the fuzzy controller is capable of keeping the load-oscillation angles small throughout the maneuvers while completing the maneuvers in relatively reasonable times.
Cx43 and the Actin Cytoskeleton: Novel Roles and Implications for Cell-Cell Junction-Based Barrier Function Regulation
Strauss, Randy E.; Gourdie, Robert G. (MDPI, 2020-12-10)
Barrier function is a vital homeostatic mechanism employed by epithelial and endothelial tissue. Diseases across a wide range of tissue types involve dynamic changes in transcellular junctional complexes and the actin cytoskeleton in the regulation of substance exchange across tissue compartments. In this review, we focus on the contribution of the gap junction protein, Cx43, to the biophysical and biochemical regulation of barrier function. First, we introduce the structure and canonical channel-dependent functions of Cx43. Second, we define barrier function and examine the key molecular structures fundamental to its regulation. Third, we survey the literature on the channel-dependent roles of connexins in barrier function, with an emphasis on the role of Cx43 and the actin cytoskeleton. Lastly, we discuss findings on the channel-independent roles of Cx43 in its associations with the actin cytoskeleton and focal adhesion structures highlighted by PI3K signaling, in the potential modulation of cellular barriers. Mounting evidence of crosstalk between connexins, the cytoskeleton, focal adhesion complexes, and junctional structures has led to a growing appreciation of how barrier-modulating mechanisms may work together to effect solute and cellular flux across tissue boundaries. This new understanding could translate into improved therapeutic outcomes in the treatment of barrier-associated diseases.
The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner
Strauss, Randy E.; Mezache, Louisa; Veeraraghavan, Rengasayee; Gourdie, Robert G. (MDPI, 2021-08-12)
The Cx43 carboxyl-terminus (CT) mimetic peptide, αCT1, originally designed to bind to Zonula Occludens 1 (ZO1) and thereby inhibit Cx43/ZO1 interaction, was used as a tool to probe the role of Cx43/ZO1 association in regulation of epithelial/endothelial barrier function. Using both in vitro and ex vivo methods of barrier function measurement, including Electric Cell-Substrate Impedance Sensing (ECIS), a TRITC-dextran Transwell permeability assay, and a FITC-dextran cardiovascular leakage protocol involving Langendorff-perfused mouse hearts, αCT1 was found to protect the endothelium from thrombin-induced breakdown in cell–cell contacts. Barrier protection was accompanied by significant remodeling of the F-actin cytoskeleton, characterized by a redistribution of F-actin away from the cytoplasmic and nuclear regions of the cell, towards the endothelial cell periphery, in association with alterations in cellular chiral orientation distribution. In line with observations of increased cortical F-actin, αCT1 upregulated cell–cell border localization of endothelial VE-cadherin, the tight junction protein Zonula Occludens 1 (ZO1), and the Gap Junction Protein (GJ) Connexin43 (Cx43). A ZO1 binding-incompetent variant of αCT1, αCT1-I, indicated that these effects on barrier function and barrier-associated proteins, were likely associated with Cx43 CT sequences retaining ability to interact with ZO1. These results implicate the Cx43 CT and its interaction with ZO1, in the regulation of endothelial barrier function, while revealing the therapeutic potential of αCT1 in the treatment of vascular edema.
Cytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapies
Graybill, Philip M.; Davalos, Rafael V. (MDPI, 2020-04-30)
Pulsed electric fields (PEFs) have become clinically important through the success of Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs (nsPEFs) for the treatment of tumors. PEFs increase the permeability of cell membranes, a phenomenon known as electroporation. In addition to well-known membrane effects, PEFs can cause profound cytoskeletal disruption. In this review, we summarize the current understanding of cytoskeletal disruption after PEFs. Compiling available studies, we describe PEF-induced cytoskeletal disruption and possible mechanisms of disruption. Additionally, we consider how cytoskeletal alterations contribute to cell–cell and cell–substrate disruption. We conclude with a discussion of cytoskeletal disruption-induced anti-vascular effects of PEFs and consider how a better understanding of cytoskeletal disruption after PEFs may lead to more effective therapies.
A Decellularized Porcine Xenograft-Derived Bone Scaffold for Clinical Use as a Bone Graft Substitute: A Critical Evaluation of Processing and Structure
Bracey, Daniel N.; Seyler, Thorsten M.; Jinnah, Alexander H.; Lively, Mark O.; Willey, Jeffrey S.; Smith, Thomas L.; Van Dyke, Mark E.; Whitlock, Patrick W. (MDPI, 2018-07-12)
Background: Bone grafts are used in approximately one half of all musculoskeletal surgeries. Autograft bone is the historic gold standard but is limited in supply and its harvest imparts significant morbidity to the patient. Alternative sources of bone graft include allografts, synthetics and, less commonly, xenografts which are taken from animal species. Xenografts are available in unlimited supply from healthy animal donors with controlled biology, avoiding the risk of human disease transmission, and may satisfy current demand for bone graft products. Methods: In the current study, cancellous bone was harvested from porcine femurs and subjected to a novel decellularization protocol to derive a bone scaffold. Results: The scaffold was devoid of donor cellular material on histology and DNA sampling (p < 0.01). Microarchitectural properties important for osteoconductive potential were preserved after decellularization as shown by high resolution imaging modalities. Proteomics data demonstrated similar profiles when comparing the porcine bone scaffold against commercially available human demineralized bone matrix approved for clinical use. Conclusion: We are unaware of any porcine-derived bone graft products currently used in orthopaedic surgery practice. Results from the current study suggest that porcine-derived bone scaffolds warrant further consideration to serve as a potential bone graft substitute.
Derivation of Equations for Flexible Multibody Systems in Terms of Quasi-Coordinates from the Extended Hamilton’s Principle
Meirovitch, L. (Hindawi, 1993-01-01)
Early derivations of the equations of motion for single rigid bodies, single flexible bodies, and flexible multibody systems in terms of quasi-coordinates have been carried out in two stages. The first consists of the use of the extended Hamilton’s principle to derive standard Lagrange’s equations in terms of generalized coordinates and the second represents a transformation of the Lagrange’s equations to equations in terms of quasi-coordinates. In this article, hybrid (ordinary and partial) differential equations for flexible multibody systems are derived in terms of quasi-coordinates directly from the extended Hamilton's principle. The approach has beneficial implications in an eventual spatial discretization of the problem.
Distinguishing the Unique Neuropathological Profile of Blast Polytrauma
Hubbard, W. Brad; Greenberg, Shaylen; Norris, Carly; Eck, Joseph; Lavik, Erin; VandeVord, Pamela J. (Hindawi, 2017-03-23)
Traumatic brain injury sustained after blast exposure (blast-induced TBI) has recently been documented as a growing issue for military personnel. Incidence of injury to organs such as the lungs has decreased, though current epidemiology still causes a great public health burden. In addition, unprotected civilians sustain primary blast lung injury (PBLI) at alarming rates. Often, mild-to-moderate cases of PBLI are survivable with medical intervention, which creates a growing population of survivors of blast-induced polytrauma (BPT) with symptoms from blast-induced mild TBI (mTBI). Currently, there is a lack of preclinical models simulating BPT, which is crucial to identifying unique injury mechanisms of BPT and its management. To meet this need, our group characterized a rodent model of BPT and compared results to a blast-induced mTBI model. Open field (OF) performance trials were performed on rodents at 7 days after injury. Immunohistochemistry was performed to evaluate cellular outcome at day seven following BPT. Levels of reactive astrocytes (GFAP), apoptosis (cleaved caspase-3 expression), and vascular damage (SMI-71) were significantly elevated in BPT compared to blast-induced mTBI. Downstream markers of hypoxia (HIF-1α and VEGF) were higher only after BPT. This study highlights the need for unique therapeutics and prehospital management when handling BPT.
Docetaxel facilitates lymphatic-tumor crosstalk to promote lymphangiogenesis and cancer progression
Harris, Alexandra R.; Perez, Matthew J.; Munson, Jennifer M. (2018-07-06)
Background Infiltration into lymphatic vessels is a critical step in breast cancer metastasis. Lymphatics undergo changes that facilitate metastasis as a result of activation of the cells lining lymphatic vessels, lymphatic endothelial cells (LECs). Inhibition of activation by targeting VEGFR3 can reduce invasion toward lymphatics. To best benefit patients, this approach should be coupled with standard of care that slows tumor growth, such as chemotherapy. Little is known about how chemotherapies, like docetaxel, may influence lymphatics and conversely, how lymphatics can alter responses to therapy. Methods A novel 3D in vitro co-culture model of the human breast tumor microenvironment was employed to examine the contribution of LECs to tumor invasion and viability with docetaxel and anti-VEGFR3, using three cell lines, MDA-MB-231, HCC38, and HCC1806. In vivo, the 4T1 mouse model of breast carcinoma was used to examine the efficacy of combinatorial therapy with docetaxel and anti-VEGFR3 on lymph node metastasis and tumor growth. Lymphangiogenesis in these mice was analyzed by immunohistochemistry and flow cytometry. Luminex analysis was used to measure expression of lymphangiogenic cytokines. Results In vitro, tumor cell invasion significantly increased with docetaxel when LECs were present; this effect was attenuated by inhibition of VEGFR3. LECs reduced docetaxel-induced cell death independent of VEGFR3. In vivo, docetaxel significantly increased breast cancer metastasis to the lymph node. Docetaxel and anti-VEGFR3 combination therapy reduced lymph node and lung metastasis in 4T1 and synergized to reduce tumor growth. Docetaxel induced VEGFR3-dependent vessel enlargement, lymphangiogenesis, and expansion of the LEC population in the peritumoral microenvironment, but not tumor-free stroma. Docetaxel caused an upregulation in pro-lymphangiogenic factors including VEGFC and TNF-α in the tumor microenvironment in vivo. Conclusions Here we present a counter-therapeutic effect of docetaxel chemotherapy that triggers cancer cells to elicit lymphangiogenesis. In turn, lymphatics reduce cancer response to docetaxel by altering the cytokine milieu in breast cancer. These changes lead to an increase in tumor cell invasion and survival under docetaxel treatment, ultimately reducing docetaxel efficacy. These docetaxel-induced effects can be mitigated by anti-VEGFR3 therapy, resulting in a synergism between these treatments that reduces tumor growth and metastasis.
Dynamic Analysis and Design Optimization of a Drag-Based Vibratory Swimmer
Tahmasian, Sevak; Jafaryzad, Arsam; Bulzoni, Nicolas L.; Staples, Anne E. (MDPI, 2020-03-22)
Many organisms achieve locomotion via reciprocal motions. This paper presents the dynamic analysis and design optimization of a vibratory swimmer with asymmetric drag forces and fluid added mass. The swimmer consists of a floating body with an oscillatory mass inside. One-dimensional oscillations of the mass cause the body to oscillate with the same frequency as the mass. An asymmetric rigid fin attached to the bottom of the body generates asymmetric hydrodynamic forces, which drive the swimmer either backward or forward on average, depending on the orientation of the fin. The equation of motion of the system is a time-periodic, piecewise-smooth differential equation. We use simulations to determine the hydrodynamic forces acting on the fin and averaging techniques to determine the dynamic response of the swimmer. The analytical results are found to be in good agreement with vibratory swimmer prototype experiments. We found that the average unidirectional speed of the swimmer is optimized if the ratio of the forward and backward drag coefficients is minimized. The analysis presented here can aid in the design and optimization of bio-inspired and biomimetic robotic swimmers. A magnetically controlled microscale vibratory swimmer like the one described here could have applications in targeted drug delivery.
Dynamic Analysis of Multilayers Based MEMS Resonators
Ouakad, Hassen M.; Alofi, Abdulrahman M.; Nayfeh, Ali H. (Hindawi, 2017-01-05)
The dynamic behavior of a microelectromechanical system (MEMS) parallel and electrically coupled double-layers (microbeams) based resonator is investigated. Two numerical methods were used to solve the dynamical problem: the reduced-order modeling (ROM) and the perturbation method. The ROM was derived using the so-called Galerkin expansion with considering the linear undamped mode shapes of straight beam as the basis functions. The perturbation method was generated using the method of multiple scales by direct attack of the equations of motion. Dynamic analyses, assuming the above two numerical methods were performed, and a comparison of the results showed good agreement. Finally, a parametric study was performed using the perturbation on different parameters and the results revealed different interesting features, which hopefully can be useful for some MEMS based applications.
Dynamic Behavior of Elastically Tailored Rotating Blades Modeled as Pretwisted Thin-Walled Beamsand Incorporating Adaptive Capabilities
Song, Ohseop S.; Oh, Sang-Yong; Librescu, Liviu (Hindawi, 2002-01-01)

Browse

Browsing Journals by Department "Biomedical Engineering and Mechanics"

Results Per Page

Sort Options