Center for the Mathematics of Biosystems
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The Center for the Mathematics of Biosystems was created in 2024 and incorporates the former Interdisciplinary Center for Applied Mathematics (ICAM).
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Browsing Center for the Mathematics of Biosystems by Subject "continuous"
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- On efficient solutions to the continuous sensitivity equation using automatic differentiationBorggaard, Jeffrey T.; Verma, Arun (Siam Publications, 2000-06)Shape sensitivity analysis is a tool that provides quantitative information about the influence of shape parameter changes on the solution of a partial differential equation (PDE). These shape sensitivities are described by a continuous sensitivity equation (CSE). Automatic differentiation (AD) can be used to perform this sensitivity analysis without writing any additional code to solve the sensitivity equation. The approximate solution of the PDE uses a spatial discretization (mesh) that often depends on the shape parameters. Therefore, the straightforward application of AD introduces derivatives of the mesh. There are two drawbacks to this approach. First, extra computational effort (especially memory) is used in these calculations due to mesh sensitivities. Second, this mesh sensitivity information needs to be computed in order to obtain accurate results. In this work, we provide a methodology that avoids mesh sensitivities (and their drawbacks) by defining a modified PDE on a fixed domain (i.e., independent of the shape parameter) such that AD provides the desired approximation of the CSE. Using two examples, we demonstrate significant improvement in the computational effort, both in terms of floating point operations and memory requirements. We explain how these code modifications can be applied to a wide variety of practical problems with minimal changes to the original code. These changes are negligible when compared to the complexity of writing a separate solver for the sensitivity equation.