Tens of millions of Americans have lost their jobs in the wake of the COVID-19 health and economic crisis, and a sizable share of these job losses may be permanent. Unemployment rates are particularly high among adults without a college degree. Recent state policy efforts have focused on increasing re-enrollment and credentialing among adults with some college but no degree (SCND); these efforts are likely to accelerate given the COVID-19 disruptions to the U.S. economy. Yet little is actually known about the background characteristics, academic experiences, or labor market trajectories of this population. Using data from the Virginia Community College System (VCCS), the authors provide the first detailed profile on the academic, employment, and earnings trajectories of the SCND population, and how these compare on key measures to VCCS graduates. They also develop a framework for prioritizing which segments of the SCND population states might target for re-enrollment and completion interventions. This framework may be particularly useful to states that need to fill critical workforce shortages in healthcare and other sectors or re-train their workforce in the wake of mass unemployment and economic disruption stemming from the COVID-19 crisis.