Academy of Integrated Science
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Scholarly Works, Academy of Integrated Science [11]
Research articles, presentations, and other scholarship
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Synchronization between Attractors: Genomic Mechanism of Cell-Fate Change
(MDPI, 2023-07-18)Herein, we provide a brief overview of complex systems theory approaches to investigate the genomic mechanism of cell-fate changes. Cell trajectories across the epigenetic landscape, whether in development, environmental ... -
Neurocognitive and radiological changes after cranial radiation therapy in humans and rodents: a systematic review
(Taylor & Francis, 2022-05-24)Background: Radiation-induced brain injury is a common long-term side effect for brain cancer survivors, leading to a reduced quality of life. Although there is growing research pertaining to this topic, the relationship ... -
A continuous-time stochastic Boolean model provides a quantitative description of the budding yeast cell cycle
(Springer Nature, 2022-12-01)The cell division cycle is regulated by a complex network of interacting genes and proteins. The control system has been modeled in many ways, from qualitative Boolean switching-networks to quantitative differential equations ... -
Modeling and analysis of the macronutrient signaling network in budding yeast
(American Society for Cell Biology, 2021-11-01)Adaptive modulation of the global cellular growth state of unicellular organisms is crucial for their survival in fluctuating nutrient environments. Because these organisms must be able to respond reliably to ever varying ... -
Mapping the cell-membrane proteome of the SKBR3/HER2+ cell line to the cancer hallmarks
(PLOS, 2022-08-01)The hallmarks of biological processes that underlie the development of cancer have been long recognized, yet, existing therapeutic treatments cannot prevent cancer from continuing to be one of the leading causes of death ... -
Computationally efficient methods for large-scale atmospheric inverse modeling
(Copernicus, 2022-07-20)Atmospheric inverse modeling describes the process of estimating greenhouse gas fluxes or air pollution emissions at the Earth's surface using observations of these gases collected in the atmosphere. The launch of new ... -
Mathematical Models of Death Signaling Networks
(MDPI, 2022-10-01)This review provides an overview of the progress made by computational and systems biologists in characterizing different cell death regulatory mechanisms that constitute the cell death network. We define the cell death ... -
Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis
(Nature Portfolio, 2021-12-09)Different cancer cell lines can have varying responses to the same perturbations or stressful conditions. Cancer cells that have DNA damage checkpoint-related mutations are often more sensitive to gene perturbations including ... -
A Dynamic Mechanistic Model of Perceptual Binding
(MDPI, 2022-04-01)The brain’s ability to create a unified conscious representation of an object by integrating information from multiple perception pathways is called perceptual binding. Binding is crucial for normal cognitive function. ... -
Structure-preserving interpolation of bilinear control systems
(2021-06)In this paper, we extend the structure-preserving interpolatory model reduction framework, originally developed for linear systems, to structured bilinear control systems. Specifically, we give explicit construction formulae ... -
The origin of impedance rise in Ni-Rich positive electrodes for lithium-ion batteries
(2021-06-30)The cycling performance of nickel-rich lithium nickel cobalt manganese oxide (NMC) electrodes in Li-ion batteries (LIBs) partially depends on the control of the kinetics of degradation processes that result in impedance ...
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