"If cartoons were meant for adults, they'd put them on in prime time." -- Lisa Simpson, "The Simpsons", FOX Television Network. Three hundred prime time episodes later, "The Simpsons" is set to emerge as America's longest running sitcom. Homer, Bart, Marge, Lisa, and baby Maggie are among the most beloved dysfunctionals in television history. Their 300th show premiers on the FOX-TV network Feb. 16.