Research conducted at the Virginia Tech Carilion Research Institute (VTCRI) creates a bridge between basic science research at Virginia Tech and clinical expertise at Carilion Clinic and increases translational research opportunities for both partners. Research conducted by scientists at the institute is aimed at understanding the molecular basis for health and disease, and development of diagnostic tools, treatments, and therapies that will contribute to the prevention and solution of existing and emerging problems in contemporary medicine. Research areas of emphasis which presently align with areas of strength and active research at Virginia Tech include inflammation, infectious disease, neuroscience, and cardiovascular science and cardiology.

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Recent Submissions

  • Cytoprotective Effect of Recombinant Human Erythropoietin Produced in Transgenic Tobacco Plants 

    Kittur, Farooqahmed S.; Bah, Mamudou; Archer-Hartmann, Stephanie; Hung, Chiu-Yueh; Azadi, Parastoo; Ishihara, Mayumi; Sane, David C.; Xie, Jiahua (PLOS, 2013-10-04)
    Asialo-erythropoietin, a desialylated form of human erythropoietin (EPO) lacking hematopoietic activity, is receiving increased attention because of its broader protective effects in preclinical models of tissue injury. ...
  • Identification and Glycerol-Induced Correction of Misfolding Mutations in the X-Linked Mental Retardation Gene CASK 

    LaConte, Leslie E. W.; Chavan, Vrushali; Mukherjee, Konark (PLOS, 2014-02-05)
    The overwhelming amount of available genomic sequence variation information demands a streamlined approach to examine known pathogenic mutations of any given protein. Here we seek to outline a strategy to easily classify ...
  • The Role of Muscle microRNAs in Repairing the Neuromuscular Junction 

    Valdez, Gregorio; Heyer, Mary P.; Feng, Guoping; Sanes, Joshua R. (PLOS, 2014-03-24)
    microRNAs have been implicated in mediating key aspects of skeletal muscle development and responses to diseases and injury. Recently, we demonstrated that a synaptically enriched microRNA, miR-206, functions to promote ...
  • A CACNA1C Variant Associated with Reduced Voltage-Dependent Inactivation, Increased Ca(V)1.2 Channel Window Current, and Arrhythmogenesis 

    Hennessey, Jessica A.; Boczek, Nicole J.; Jiang, Yong-Hui; Miller, Joelle D.; Patrick, William; Pfeiffer, Ryan; Sutphin, Brittan S.; Tester, David J.; Barajas-Martinez, Hector; Ackerman, Michael J.; Antzelevitch, Charles; Kanter, Ronald; Pitt, Geoffrey S. (PLOS, 2014-09-03)
    Mutations in CACNA1C that increase current through the CaV1.2 L-type Ca2+ channel underlie rare forms of long QT syndrome (LQTS), and Timothy syndrome (TS). We identified a variant in CACNA1C in a male child of Filipino ...
  • Central Presynaptic Terminals Are Enriched in ATP but the Majority Lack Mitochondria 

    Chavan, Vrushali; Willis, Jeffery; Walker, Sidney K.; Clark, Helen R.; Liu, Xinran; Fox, Michael A.; Srivastava, Sarika; Mukherjee, Konark (PLOS, 2015-04-30)
    Synaptic neurotransmission is known to be an energy demanding process. At the presynapse, ATP is required for loading neurotransmitters into synaptic vesicles, for priming synaptic vesicles before release, and as a substrate ...
  • Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders 

    Moustafa, Dina A.; Scarff, Jennifer M.; Garcia, Preston P.; Cassidy, Sara K. B.; DiGiandomenico, Antonio; Waag, David M.; Inzana, Thomas J.; Goldberg, Joanna B. (PLOS, 2015-07-06)
    Burkholderia pseudomallei and Burkholderia mallei are the etiologic agents of melioidosis and glanders, respectively. These bacteria are highly infectious via the respiratory route and can cause severe and often fatal ...
  • Regret Expression and Social Learning Increases Delay to Sexual Gratification 

    Quisenberry, Amanda J.; Eddy, Celia R.; Patterson, David L.; Franck, Christopher T.; Bickel, Warren K. (PLOS, 2015-08-17)
    Objective Modification and prevention of risky sexual behavior is important to individuals’ health and public health policy. This study employed a novel sexual discounting task to elucidate the effects of social learning ...
  • Associations between Religiosity, Spirituality, and Happiness among Adults Living with Neurological Illness 

    Wade, James B.; Hayes, Rashelle B.; Wade, James H.; Bekenstein, Jonathan W.; Williams, Kristin D.; Bajaj, Jasmohan S. (MDPI, 2018-06-23)
    The study examined the associations between religiosity, spirituality, and happiness in 354 outpatients suffering from neurological disorders. After accounting for severity of cognitive decline, physical activity level, ...
  • Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival 

    Varghese, Robin T.; Young, Sarah; Pham, Lily; Liang, Yanping; Pridham, Kevin J.; Guo, Sujuan; Murphy, Susan; Kelly, Deborah F.; Sheng, Zhi (Nature, 2018-09-11)
    Glioblastoma is the most common malignant brain cancer with a dismal prognosis. The difficulty in treating glioblastoma is largely attributed to the lack of effective therapeutic targets. In our previous work, we identified ...
  • BDNF Val(66)Met Polymorphism Is Associated with Self-Reported Empathy 

    Taschereau-Dumouchel, Vincent; Hetu, Sebastien; Bagramian, Anait; Labrecque, Alexandre; Racine, Marion; Chagnon, Yvon C.; Jackson, Philip L. (PLOS, 2016-02-12)
    Empathy is an important driver of human social behaviors and presents genetic roots that have been studied in neuroimaging using the intermediate phenotype approach. Notably, the Val66Met polymorphism of the Brain-derived ...
  • Low Dose Infliximab for Prevention of Postoperative Recurrence of Crohn's Disease: Long Term Follow-Up and Impact of Infliximab Trough Levels and Antibodies to Infliximab 

    Sorrentino, Dario; Marino, Marco; Dassopoulos, Themistocles; Zarifi, Dimitra; Del Bianco, Tiziana (PLOS, 2015-12-15)
    Objective In patients with postoperative recurrence of Crohn’s disease endoscopic and clinical remission can be maintained for up to 1 year with low infliximab doses (3 mg/Kg). However, in theory low-dose infliximab ...
  • LRRTM1 underlies synaptic convergence in visual thalamus 

    Monavarfeshani, Aboozar; Stanton, Gail; Van Name, Jonathan; Su, Kaiwen; Mills, William A., III; Swilling, Kenya; Kerr, Alicia; Huebschman, Natalie A.; Su, Jianmin; Fox, Michael A. (eLife, 2018-02-09)
    It has long been thought that the mammalian visual system is organized into parallel pathways, with incoming visual signals being parsed in the retina based on feature (e.g. color, contrast and motion) and then transmitted ...
  • Inhibitory Control Mediates the Association between Perceived Stress and Secure Relationship Quality 

    Herd, Toria; Li, Mengjiao; Maciejewski, Dominique; Lee, Jacob; Deater-Deckard, Kirby; King-Casas, Brooks; Kim-Spoon, Jungmeen (Frontiers, 2018-02-26)
    Past research has demonstrated negative associations between exposure to stressors and quality of interpersonal relationships among children and adolescents. Nevertheless, underlying mechanisms of this association remain ...
  • Wellness Weekly, February 10, 2017 

    Unknown author (Virginia Tech, 2017-02-10)
    Weekly recipes, tips, and tricks on improving student wellness from the Virginia Tech Carilion School of Medicine.
  • Wellness Weekly, December 9, 2016 

    Unknown author (Virginia Tech, 2016-12-09)
    Weekly recipes, tips, and tricks on improving student wellness from the Virginia Tech Carilion School of Medicine.
  • Wellness Weekly, February 17, 2017 

    Unknown author (Virginia Tech, 2017-02-17)
    Weekly recipes, tips, and tricks on improving student wellness from the Virginia Tech Carilion School of Medicine.
  • Wellness Weekly, February 16, 2018 

    Unknown author (Virginia Tech, 2018-02-16)
    Weekly recipes, tips, and tricks on improving student wellness from the Virginia Tech Carilion School of Medicine.
  • Wellness Weekly, December 30, 2016 

    Unknown author (Virginia Tech, 2016-12-30)
    Weekly recipes, tips, and tricks on improving student wellness from the Virginia Tech Carilion School of Medicine.
  • Wellness Weekly, December 8, 2017 

    Unknown author (Virginia Tech, 2017-12-08)
    Weekly recipes, tips, and tricks on improving student wellness from the Virginia Tech Carilion School of Medicine.
  • Wellness Weekly, December 2, 2016 

    Unknown author (Virginia Tech, 2016-12-02)
    Weekly recipes, tips, and tricks on improving student wellness from the Virginia Tech Carilion School of Medicine.

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