Recent Submissions

  • NLRX1 Is a Multifaceted and Enigmatic Regulator of Immune System Function 

    Nagai-Singer, Margaret A.; Morrison, Holly A.; Allen, Irving C. (2019-10-11)
    Over the last decade, significant progress has been achieved in defining mechanisms underlying NLR regulation of immune system function. However, several NLR family members continue to defy our best attempts at characterization ...
  • Selective Histone Deacetylase 6 Inhibition Normalizes B Cell Activation and Germinal Center Formation in a Model of Systemic Lupus Erythematosus 

    Ren, Jingjing; Catalina, Michelle D.; Eden, Kristin; Liao, Xiaofeng; Read, Kaitlin A.; Luo, Xin; McMillan, Ryan P.; Hulver, Matthew W.; Jarpe, Matthew; Bachali, Prathyusha; Grammer, Amrie C.; Lipsky, Peter E.; Reilly, Christopher M. (2019-10-25)
    Autoantibody production by plasma cells (PCs) plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). The molecular pathways by which B cells become pathogenic PC secreting autoantibodies in SLE are ...
  • Drug-Susceptible and Multidrug-Resistant Mycobacterium tuberculosis in a Single Patient 

    Baffoe-Bonnie, Anthony; Houpt, Eric R.; Turner, Lauren; Dodge, Denise; Heysell, Scott K. (2019-11)
    A patient who had initial infection with mixed strains of drug-susceptible and multidrug-resistant tuberculosis was presumed to have acquired drug resistance before confirmation that sequential strains were genotypically ...
  • Case study on the use of intensive pediatric neurorehabilitation in the treatment of kernicterus 

    Mann, Jessie; Wallace, Dory A.; DeLuca, Stephanie (2020-02-03)
    Background Kernicterus Spectrum Disorder (KSD) is the result of prolonged bilirubin toxicity resulting in widespread neurological injury. Once the bilirubin levels are normalized the encephalopathy becomes static, however ...
  • Multimodal Imaging of Nonenhancing Glioblastoma Regions 

    John, Flora; Robinette, Natasha L.; Amit-Yousif, Alit J.; Bosnyak, Edit; Barger, Geoffrey R.; Shah, Keval D.; Mittal, Sandeep; Juhasz, Csaba (2019-11-13)
    Background: Clinical glioblastoma treatment mostly focuses on the contrast-enhancing tumor mass. Amino acid positron emission tomography (PET) can detect additional, nonenhancing glioblastoma-infiltrated brain regions that ...
  • Longitudinal link between trait motivation and risk-taking behaviors via neural risk processing 

    Li, Mengjiao; Lauharatanahirun, Nina; Steinberg, Laurence; King-Casas, Brooks; Kim-Spoon, Jungmeen; Deater-Deckard, Kirby (2019-12)
    Prior research has emphasized the importance of the motivational system in risky decision-making, yet the mechanisms through which individual differences in motivation may influence adolescents' risk-taking behaviors remain ...
  • Women Physicians: Gender and the Medical Workplace 

    Rouse, Linda P.; Nagy-Agren, Stephanie E.; Gebhard, Roberta E.; Bernstein, Wendy K. (Mary Ann Liebert, 2020-01-20)
    Understanding the work habits, attitudes, and experiences of women physicians is critical for optimal patient care. An analysis of the medical literature (1990–2017) was undertaken to answer the following question: how are ...
  • Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid 

    Jo, Ami; Ringel-Scaia, Veronica M.; McDaniel, Dylan K.; Thomas, Cassidy A.; Zhang, Rui; Riffle, Judy S.; Allen, Irving C.; Davis, Richey M. (2020-01-20)
    Abstract Background The clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of the utility of CRISPR–Cas9 for in ...
  • Laparoscopic repair of interparietal abdominal wall hernias 

    Kalmar, Christopher L.; Bower, Curtis E. (Oxford University Press, 2019-10-01)
    Interparietal hernias are rare abdominal defects where intraabdominal contents protrude between layers of the abdominal wall. There is limited experience using laparoscopic technique for repairing substantially large ...
  • Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix) 

    Senger, Ryan S.; Kavuru, Varun; Sullivan, Meaghan; Gouldin, Austin; Lundgren, Stephanie; Merrifield, Kristen; Steen, Caitlin; Baker, Emily; Vu, Tommy; Agnor, Ben; Martinez, Gabrielle; Coogan, Hannah; Carswell, William; Karageorge, Lampros; Dev, Devasmita; Du, Pang; Sklar, Allan; Orlando, Giuseppe; Pirkle, James, Jr.; Robertson, John L. (PLOS, 2019-09-27)
    Raman chemometric urinalysis (Rametrix™) was used to analyze 235 urine specimens from healthy individuals. The purpose of this study was to establish the “range of normal” for Raman spectra of urine specimens from healthy ...
  • Simultaneous involvement of optic and abducens nerves by Lyme disease: Case report with review of the literature 

    Dabiri, Iman; Burakgazi, Ahmet Z. (PAGEPress, 2019)
    Ocular manifestations of Lyme disease (LD) remain a rare feature of the disease, but it may present a wide range of clinical presentations with different combinations. LD related optic neuritis or cranial nerve (CN) six ...
  • Atypical presentation of Lyme neuroborreliosis related meningitis and radiculitis 

    Dabiri, Iman; Calvo, Nicholas; Nauman, Feryal; Pahlavanzadeh, Mahsa; Burakgazi, Ahmet Z. (PAGEPress, 2019-10-11)
    Lyme disease related central and peripheral nervous system manifestations can occur in isolation or together. Radiculitis or inflammation of the nerve root can be seen 3-5% of the time in acute neuroborreliosis affecting ...
  • Diagnosis and Treatment of a Benign Pediatric Mandible Tumor 

    Joy, Matthew T.; Liao, Christopher D.; Magdycz, William P.; Parulis, Albert W.; Thompson, James D. (Ovid Technologies, 2019-10-15)
    Pediatric mandible tumors are rare and generally benign but can be locally aggressive. Diagnosis and treatment involve tumor identification, excision, and subsequent reconstruction. Successful reconstruction should address ...
  • Faculty Resources for Educational Excellence (FREE) Newsletter, December 2019 

    Unknown author (Virginia Tech Carilion School of Medicine, 2019-12)
    This newsletter focuses each month on some aspect of faculty development, including tips, resources and various opportunities designed to support faculty success at the Virginia Tech Carilion School of Medicine. In this ...
  • Faculty Resources for Educational Excellence (FREE) Newsletter, November 2019 

    Unknown author (Virginia Tech Carilion School of Medicine, 2019-11)
    This newsletter focuses each month on some aspect of faculty development, including tips, resources and various opportunities designed to support faculty success at the Virginia Tech Carilion School of Medicine. In this ...
  • Metastatic Multiple Myeloma to the Skin 

    Holliday, Alex C.; Khan, Mohammed I.; Mazloom, Sean E.; Chavan, Rahul N.; Grider, Douglas J. (Hindawi, 2019-11-12)
    Cutaneous involvement of multiple myeloma (MM) is uncommon, typically occurs in late stage disease, and is a poor prognostic indicator with an approximate eight month median survival. We present a 51-year-old man with ...
  • Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor 

    Mograbi, Madison; Stump, Michael S.; Luyimbazi, David T.; Shakhatreh, Mohammad H.; Grider, Douglas J. (Hindawi, 2019-12-05)
    Follicular dendritic cell sarcoma (FDCS) is a rare and underdiagnosed malignant neoplasm which characteristically presents as a solitary, slow-growing mass with no discrete symptoms. Histologically, lymphocytes and spindle ...
  • Epidermoid Cysts in a Wandering Spleen: An Unusual Enigma 

    Algino, Sarah E.; Sorrentino, Siena; Luyimbazi, David T.; Grider, Douglas J. (Hindawi, 2019-11-20)
    Epidermoid splenic cysts are rare lesions in the spleen. These cysts are characterized by a stratified squamous epithelial lining, internal septations, and calcification. Congenital in origin, epidermoid splenic cysts are ...
  • Emerging Insights into the Metabolic Alterations in Aging Using Metabolomics 

    Srivastava, Sarika (MDPI, 2019-12-13)
    Metabolomics is the latest ‘omics’ technology and systems biology science that allows for comprehensive profiling of small-molecule metabolites in biological systems at a specific time and condition. Metabolites ...
  • Dropped head syndrome due to neuromuscular disorders: Clinical manifestation and evaluation 

    Burakagazi, Ahmet Z.; Richardson, Perry K.; Abu-Rub, Mohammad (PAGEPress, 2019-06-18)
    In this article, we discuss the clinical approach to patients with dropped head syndrome and identify the various neuromuscular causes of dropped head syndrome including muscle, neuromuscular junction, peripheral nerve and ...

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