Now showing items 239-258 of 486

    • Mathematically Gifted Adolescents Have Deficiencies in Social Valuation and Mentalization 

      Yun, Kyongsik; Chung, Dongil; Jang, Bosun; Kim, Jin Ho; Jeong, Jaeseung (PLOS, 2011-04-04)
      Many mathematically gifted adolescents are characterized as being indolent, underachieving and unsuccessful despite their high cognitive ability. This is often due to difficulties with social and emotional development. ...
    • Metastatic Multiple Myeloma to the Skin 

      Holliday, Alex C.; Khan, Mohammed I.; Mazloom, Sean E.; Chavan, Rahul N.; Grider, Douglas J. (Hindawi, 2019-11-12)
      Cutaneous involvement of multiple myeloma (MM) is uncommon, typically occurs in late stage disease, and is a poor prognostic indicator with an approximate eight month median survival. We present a 51-year-old man with ...
    • Methicillin-Susceptible Staphylococcus aureus as a Predominantly Healthcare-Associated Pathogen: A Possible Reversal of Roles? 

      Zychowski, Diana L.; David, Michael Z.; Boyle-Vavra, Susan; Daum, Robert S. (PLoS, 2011-04-13)

      Background
      Methicillin-resistant Staphylococcus aureus (MRSA) strains have become common causes of skin and soft tissue infections (SSTI) among previously healthy people, a role of methicillin-susceptible (MSSA) ...

    • Microbial dysbiosis in spouses of ulcerative colitis patients: any clues to disease pathogenesis? 

      Sorrentino, Dario (2017-10-07)
      A number of alterations have been found within the gut microbial profile of patients with inflammatory bowel diseases when compared with the healthy population; however, it is unclear whether such dysbiosis is the cause ...
    • A microchip platform for structural oncology applications. 

      Winton, Carly E,; Gilmore, Brian L.; Demmert, Andrew C.; Karageorge, Vasilea; Sheng, Zhi; Kelly, Deborah F.
      Recent advances in the development of functional materials offer new tools to dissect human health and disease mechanisms. The use of tunable surfaces is especially appealing as substrates can be tailored to fit applications ...
    • Microfluidic reactors for advancing the MS analysis of fast biological responses 

      Lazar, Iulia M.; Deng, J.; Stremler, M.A.; Ahuja, S. (Nature Publishing Group, 2019-02-11)
      The response of cells to physical or chemical stimuli is complex, unfolding on time-scales from seconds to days, with or without de novo protein synthesis, and involving signaling processes that are transient or sustained. ...
    • Microvascular bioengineering: a focus on pericytes 

      Zhao, Huaning; Chappell, John C. (2019-03-29)
      Capillaries within the microcirculation are essential for oxygen delivery and nutrient/waste exchange, among other critical functions. Microvascular bioengineering approaches have sought to recapitulate many key features ...
    • Mindfulness meditation modulates reward prediction errors in a passive conditioning task 

      Kirk, Ulrich; Montague, P. Read (Frontiers, 2015-02-12)
      Reinforcement learning models have demonstrated that phasic activity of dopamine neurons during reward expectation encodes information about the predictability of reward and cues that predict reward. Self-control strategies ...
    • Minor defects of the luminal integrity in arterial introducer eSheaths after transcatheter aortic valve implantation 

      Buege, Michael; Koehler, Till; Heiderhoff, Ralf; Papenheim, Marc; Wang, Si; Schleiting, Heinrich; Arnold, Wolfgang H.; Foerst, Jason R.; Seyfarth, Melchior; Tiroch, Klaus; Riedl, Thomas; Vorpahl, Marc (PLOS, 2017-05-08)
      Background Medical devices such as implant delivery systems are commonly used during minimally invasive procedures in the cardiovascular system. These devices often have lubricious polymer coatings to reduce friction ...
    • Mismatch Responses in the Awake Rat: Evidence from Epidural Recordings of Auditory Cortical Fields 

      Jung, Fabienne; Stephan, Klaas Enno; Backes, Heiko; Moran, Rosalyn; Gramer, Markus; Kumagai, Tetsuya; Graf, Rudolf; Endepols, Heike; Tittgemeyer, Marc (PLOS, 2013-04-30)
      Detecting sudden environmental changes is crucial for the survival of humans and animals. In the human auditory system the mismatch negativity (MMN), a component of auditory evoked potentials (AEPs), reflects the violation ...
    • The Mitochondrial Basis of Aging and Age-Related Disorders 

      Srivastava, Sarika (MDPI, 2017-12-19)
      Aging is a natural phenomenon characterized by progressive decline in tissue and organ function leading to increased risk of disease and mortality. Among diverse factors that contribute to human aging, the mitochondrial ...
    • Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice 

      Krahe, Thomas E.; Seabrook, Tania A.; Chen, Ching Kang J.; Fox, Michael A.; Guido, William (Hindawi, 2012)
      The cAMP-response element-binding protein (CREB) plays an important role in visual cortical plasticity that follows the disruption of sensory activity, as induced by dark rearing (DR). Recent findings indicate that the ...
    • Modulation of gap junction-associated Cx43 in neural stem/progenitor cells following traumatic brain injury 

      Greer, Kisha; Chen, Jiang; Brickler, Thomas; Gourdie, Robert; Theus, Michelle H. (2017-09)
      Restoration of learning and memory deficits following traumatic brain injury (TBI) is attributed, in part, to enhanced neural stem/progenitor cell (NSPCs) function. Recent findings suggest gap junction (GJ)-associated ...
    • Molecular Analysis of BRCA1 in Human Breast Cancer Cells Under Oxidative Stress 

      Gilmore, Brian L.; Liang, Yanping; Winton, Carly E.; Patel, Kaya; Karageorge, Vasilea; Varano, A. Cameron; Dearnaley, Wwilliam; Sheng, Zhi; Kelly, Deborah F. (Nature Publishing Group, 2017-03-06)
      The precise manner in which physical changes to the breast cancer susceptibility protein (BRCA1) affect its role in DNA repair events remain unclear. Indeed, cancer cells harboring mutations in BRCA1 suffer from genomic ...
    • Molecular mechanisms of experience-dependent plasticity in visual cortex 

      Van Wart, Audra; Tropea, Daniela; Sur, Mriganka (Royal Society, 2008)
      A remarkable amount of our current knowledge of mechanisms underlying experience-dependent plasticity during cortical development comes from study of the mammalian visual cortex. Recent advances in high-resolution cellular ...
    • Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy. 

      Kelly, Deborah F.; Lake, Robert J.; Middelkoop, Teije C.; Fan, Hua-Ying; Artavanis-Tsakonas, Spyros; Walz, Thomas (2010-05-07)
      BACKGROUND: The Notch receptor links cell fate decisions of one cell to that of the immediate cellular neighbor. In humans, malfunction of Notch signaling results in diseases and congenital disorders. Structural information ...
    • Molecular Surveillance of Viral Processes Using Silicon Nitride Membranes 

      Gilmore, Brian L.; Tanner, Justin R.; McKell, Allison O.; Boudreaux, Crystal E.; Dukes, Madeline J.; McDonald, Sarah M.; Kelly, Deborah F. (MDPI, 2013-03)
      Here we present new applications for silicon nitride (SiN) membranes to evaluate biological processes. We determined that 50-nanometer thin films of SiN produced from silicon wafers were sufficiently durable to bind active ...
    • A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease 

      Gilmore, Brian L.; Winton, Carly E.; Demmert, Andrew C.; Tanner, Justin R.; Bowman, Sam; Karageorge, Vasilea; Patel, Kaya; Sheng, Zhi; Kelly, Deborah F. (Springer Nature, 2015-09-23)
      We present a new molecular toolkit to investigate protein assemblies natively formed in the context of human disease. The system employs tunable microchips that can be decorated with switchable adaptor molecules to select ...
    • Monetary Favors and Their Influence on Neural Responses and Revealed Preference 

      Harvey, Ann H.; Kirk, Ulrich; Denfield, George H.; Montague, P. Read (Society for Neuroscience, 2010-07-14)
      Favors from a sender to a receiver are known to bias decisions made by the recipient, especially when the decision relates to the sender, a feature of social exchange known as reciprocity. Using an art-viewing paradigm ...
    • Monte Carlo Planning Method Estimates Planning Horizons during Interactive Social Exchange 

      Hula, Andreas; Montague, P. Read; Dayan, Peter (PLOS, 2015-06)
      Reciprocating interactions represent a central feature of all human exchanges. They have been the target of various recent experiments, with healthy participants and psychiatric populations engaging as dyads in multi-round ...