Now showing items 1-20 of 444

    • Dendritic Spikes and Their Influence on Extracellular Calcium Signaling 

      Wiest, Michael C.; Eagleman, David M.; King, Richard D.; Montague, P. Read (American Physiological Society, 2000)
      Extracellular calcium is critical for many neural functions, including neurotransmission, cell adhesion, and neural plasticity. Experiments have shown that normal neural activity is associated with changes in extracellular ...
    • LTD Induction in Adult Visual Cortex: Role of Stimulus Timing and Inhibition 

      Perrett, Stephen P.; Dudek, Serena M.; Eagleman, David; Montague, P. Read; Friedlander, Michael J. (Society for Neuroscience, 2001-04-01)
      One Hertz stimulation of afferents for 15 min with constant interstimulus intervals (regular stimulation) can induce longterm depression (LTD) of synaptic strength in the neocortex. However, it is unknown whether natural ...
    • Predictability Modulates Human Brain Response to Reward 

      Berns, Gregory S.; McClure, Samuel M.; Pagnoni, Guiseppe; Montague, P. Read (Society for Neuroscience, 2001-04-15)
      Certain classes of stimuli, such as food and drugs, are highly effective in activating reward regions. We show in humans that activity in these regions can be modulated by the predictability of the sequenced delivery of ...
    • When Things Are Better or Worse than Expected: The Medial Frontal Cortex and the Allocation of Processing Resources 

      Potts, Geoffrey F.; Martin, Laura E.; Burton, Philip; Montague, P. Read (MIT, 2006)
      Access to limited-capacity neural systems of cognitive control must be restricted to the most relevant information. How the brain identifies and selects items for preferential processing is not fully understood. Anatomical ...
    • Policy Adjustment in a Dynamic Economic Game 

      Li, Jian; McClure, Samuel M.; King-Casas, Brooks; Montague, P. Read (PLOS, 2006)
      Making sequential decisions to harvest rewards is a notoriously difficult problem. One difficulty is that the real world is not stationary and the reward expected from a contemplated action may depend in complex ways on ...
    • Policy Adjustment in a Dynamic Economic Game 

      Li, Jian; McClure, Samuel M.; King-Casas, Brooks; Montague, P. Read (PLOS, 2006-12)
      Making sequential decisions to harvest rewards is a notoriously difficult problem. One difficulty is that the real world is not stationary and the reward expected from a contemplated action may depend in complex ways on ...
    • Neural signature of fictive learning signals in a sequential investment task 

      Lohrenz, Terry; McCabe, Kevin; Camerer, Colin F.; Montague, P. Read (NAS, 2007-04-13)
      Reinforcement learning models now provide principled guides for a wide range of reward learning experiments in animals and humans. One key learning (error) signal in these models is experiential and reports ongoing temporal ...
    • Molecular mechanisms of experience-dependent plasticity in visual cortex 

      Van Wart, Audra; Tropea, Daniela; Sur, Mriganka (Royal Society, 2008)
      A remarkable amount of our current knowledge of mechanisms underlying experience-dependent plasticity during cortical development comes from study of the mammalian visual cortex. Recent advances in high-resolution cellular ...
    • Gene expression patterns in visual cortex during the critical period: Synaptic stabilization and reversal by visual deprivation 

      Van Wart, Audra; Lyckman, Alvin W.; Horng, Sam; Leamey, Catherine A.; Tropea, Daniela; Watakabe, Akiya; McCurry, Cortina; Yamamori, Tetsuo; Sur, Mriganka (National Academy of Sciences, 2008-07)
      The mapping of eye-specific, geniculocortical inputs to primary visual cortex (V1) is highly sensitive to the balance of correlated activity between the two eyes during a restricted postnatal critical period for ocular ...
    • Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction 

      Nishimune, Hiroshi; Valdez, Gregorio; Jarad, George; Moulson, Casey L.; Müller, Ulrich; Miner, Jeffrey H.; Sanes, Joshua R. (The Rockefeller University Press, 2008-09-15)
      A prominent feature of synaptic maturation at the neuromuscular junction (NMJ) is the topological transformation of the acetylcholine receptor (AChR)-rich postsynaptic membrane from an ovoid plaque into a complex array of ...
    • Remote Excitation of Neuronal Circuits Using Low- Intensity, Low-Frequency Ultrasound 

      Tyler, William J; Tufail, Yusuf; Finsterwald, Michael; Tauchmann, Monica L.; Olson, Emily J.; Majestic, Cassondra (PLOS, 2008-10-29)
      Possessing the ability to noninvasively elicit brain circuit activity yields immense experimental and therapeutic power. Most currently employed neurostimulation methods rely on the somewhat invasive use of stimulating ...
    • Alexithymic Trait and Voluntary Control in Healthy Adults 

      Gu, Xiaosi; Liu, Xun; Guise, Kevin G.; Fossella, John; Wang, Kai; Fan, Jin (PLOS, 2008-11-12)
      Background: Alexithymia is a personality trait characterized by deficiency in understanding, processing, or describing emotions. Recent studies have revealed that alexithymia is associated with less activation of the ...
    • Congruence of BOLD Response across Intertemporal Choice Conditions: Fictive and Real Money Gains and Losses 

      Bickel, Warren K.; Pitcock, Jeffery A.; Yi, Richard; Angtuaco, Edgardo J.C. (Society for Neuroscience, 2009-07-08)
      Intertemporal choice is predicated on the valuation of commodities with respect to delay until their receipt. Subjective value of a future outcome decreases, or is discounted, as a function of that delay (Bickel and Johnson, ...
    • Ready…Go: Amplitude of the fMRI Signal Encodes Expectation of Cue Arrival Time 

      Cui, Xu; Stetson, Chess; Montague, P. Read; Eagleman, David M. (PLOS, 2009-08-04)
      What happens when the brain awaits a signal of uncertain arrival time, as when a sprinter waits for the starting pistol? And what happens just after the starting pistol fires? Using functional magnetic resonance imaging ...
    • Neural responses to sanction threats in two-party economic exchange 

      Li, Jian; Xiao, Erte; Houser, Daniel; Montague, P. Read (NAS, 2009-08-11)
      Sanctions are used ubiquitously to enforce obedience to social norms. However, recent field studies and laboratory experiments have demonstrated that cooperation is sometimes reduced when incentives meant to promote prosocial ...
    • Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy. 

      Kelly, DF; Lake, RJ; Middelkoop, TC; Fan, H-Y; Artavanis-Tsakonas, S; Walz, T (2010-05-07)
      BACKGROUND: The Notch receptor links cell fate decisions of one cell to that of the immediate cellular neighbor. In humans, malfunction of Notch signaling results in diseases and congenital disorders. Structural information ...
    • BOLD responses to negative reward prediction errors in human habenula 

      Salas, Ramiro; Baldwin, Philip; Biasi, Mariella de; Montague, P. Read (Frontiers, 2010-05-11)
      Although positive reward prediction error, a key element in learning that is signaled by dopamine cells, has been extensively studied, little is known about negative reward prediction errors in humans. Detailed animal ...
    • Monetary Favors and Their Influence on Neural Responses and Revealed Preference 

      Harvey, Ann H.; Kirk, Ulrich; Denfield, George H.; Montague, P. Read (Society for Neuroscience, 2010-07-14)
      Favors from a sender to a receiver are known to bias decisions made by the recipient, especially when the decision relates to the sender, a feature of social exchange known as reciprocity. Using an art-viewing paradigm ...
    • Neural signatures of strategic types in a two-person bargaining game 

      Bhatt, Meghana A.; Lohrenz, Terry; Camerer, Colin F.; Montague, P. Read (NAS, 2010-09-28)
      The management and manipulation of our own social image in the minds of others requires difficult and poorly understood computations. One computation useful in social image management is strategic deception: our ability ...
    • Biosensor Approach to Psychopathology Classification 

      Koshelev, Misha; Lohrenz, Terry; Vannucci, Marina; Montague, P. Read (PLOS, 2010-10-21)
      We used a multi-round, two-party exchange game in which a healthy subject played a subject diagnosed with a DSM-IV (Diagnostic and Statistics Manual-IV) disorder, and applied a Bayesian clustering approach to the behavior ...