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Randomized Manipulation of Early Cognitive Experience Impacts Adult Brain Structure
(Massachusetts Institute of Technology, 2021)
Does early exposure to cognitive and linguistic stimulation impact brain structure? Or do genetic predispositions account for the co-occurrence of certain neuroanatomical phenotypes and a tendency to engage children in ...
Irrational exuberance and neural crash warning signals during endogenous experimental market bubbles
(NAS, 2014-07-22)
Groups of humans routinely misassign value to complex future events, especially in settings involving the exchange of resources. If properly structured, experimental markets can act as excellent probes of human group-level ...
Human substantia nigra and ventral tegmental area involvement in computing social error signals during the ultimatum game
(Oxford University Press, 2017-08-17)
As models of shared expectations, social norms play an essential role in our societies. Since our social environment is changing constantly, our internal models of it also need to change. In humans, there is mounting ...
Subsecond dopamine fluctuations in human striatum encode superposed error signals about actual and counterfactual reward
(NAS, 2016-01-05)
In the mammalian brain, dopamine is a critical neuromodulator whose actions underlie learning, decision-making, and behavioral control. Degeneration of dopamine neurons causes Parkinson’s disease, whereas dysregulation of ...
Computational Phenotyping of Two-Person Interactions Reveals Differential Neural Response to Depth-of-Thought
(Public Library of Science, 2012-12-27)
Reciprocating exchange with other humans requires individuals to infer the intentions of their partners. Despite the importance of this ability in healthy cognition and its impact in disease, the dimensions employed and ...
Necessary, Yet Dissociable Contributions of the Insular and Ventromedial Prefrontal Cortices to Norm Adaptation: Computational and Lesion Evidence in Humans
(Society for Neuroscience, 2015-01-14)
Social norms and their enforcement are fundamental to human societies. The ability to detect deviations from norms and to adapt to norms in a changing environment is therefore important to individuals’ normal social ...
Sub-second Dopamine and Serotonin Signaling in Human Striatum during Perceptual Decision-Making
(CellPress, 2020-12-09)
Recent animal research indicates that dopamine and serotonin, neuromodulators traditionally linked to appetitive and aversive processes, are also involved in sensory inference and decisions based on such inference. We ...
Belief about nicotine modulates subjective craving and insula activity in deprived smokers
(Frontiers, 2016-07-13)
Little is known about the specific neural mechanisms through which cognitive factors influence craving and associated brain responses, despite the initial success of cognitive therapies in treating drug addiction. In this ...
Simulating future value in intertemporal choice
(Nature, 2017-02-22)
The laboratory study of how humans and other animals trade-off value and time has a long and storied history, and is the subject of a vast literature. However, despite a long history of study, there is no agreed upon ...
Belief about nicotine selectively modulates value and reward prediction error signals in smokers
(NAS, 2015-02-24)
Little is known about how prior beliefs impact biophysically described processes in the presence of neuroactive drugs, which presents a profound challenge to the understanding of the mechanisms and treatments of addiction. ...