Research articles, presentations, and other scholarship

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  • In Situ Bioprinting of Autologous Skin Cells Accelerates Wound Healing of Extensive Excisional Full-Thickness Wounds 

    Albanna, Mohammed; Binder, Kyle W.; Murphy, Sean V.; Kim, Jaehyun; Qasem, Shadi A.; Zhao, Weixin; Tan, Josh; El-Amin, Idris B.; Dice, Dennis D.; Marco, Julie; Green, Jason; Xu, Tao; Skardal, Aleksander; Holmes, James H.; Jackson, John D.; Atala, Anthony; Yoo, James J. (Springer Nature, 2019-02-21)
    The early treatment and rapid closure of acute or chronic wounds is essential for normal healing and prevention of hypertrophic scarring. The use of split thickness autografts is often limited by the availability of a ...
  • Is sham cTBS real cTBS? The effect on EEG dynamics 

    Opitz, Alexander; Legon, Wynn; Mueller, Jerel K.; Barbour, Aaron J.; Paulus, Walter; Tyler, William J. (Frontiers Media S.A., 2015-01-08)
    Increasing sensitivity of modern evaluation tools allows for the study of weaker electric stimulation effects on neural populations. In the current study we examined the effects of sham continuous theta burst (cTBS) ...
  • GPU-Based Acceleration for Interior Tomography 

    Liu, Rui; Luo, Yan; Yu, Hengyong (IEEE, 2014)
    The compressive sensing (CS) theory shows that real signals can be exactly recovered from very few samplings. Inspired by the CS theory, the interior problem in computed tomography is proved uniquely solvable by minimizing ...
  • A Stationary-Sources and Rotating-Detectors Computed Tomography Architecture for Higher Temporal Resolution and Lower Radiation Dose 

    Cao, Guohua; Liu, Baodong; Gong, Hao; Yu, Hengyong; Wang, Ge (IEEE, 2014)
    In current computed tomography (CT) architecture, both X-ray tubes and X-ray detectors are rotated mechanically around an object to collect a sufficient number of projections. This architecture has been shown to not be ...
  • In Cocaine Dependence, Neural Prediction Errors During Loss Avoidance Are Increased With Cocaine Deprivation and Predict Drug Use 

    Wang, John M.; Zhu, Lusha; Brown, Vanessa M.; De La Garza, Richard II; Newton, Thomas; King-Casas, Brooks; Chiu, Pearl H. (Elsevier, 2018-08-03)
    Background: In substance-dependent individuals, drug deprivation and drug use trigger divergent behavioral responses to environmental cues. These divergent responses are consonant with data showing that short- and long-term ...
  • Devices and methods for contactless dielectrophoresis for cell or particle manipulation 

    Virginia Tech Intellectual Properties, Inc.; Davalos, Rafael V.; Shafiee, Hadi; Sano, Michael B.; Caldwell, John L. (United States Patent and Trademark Office, 2018-09-18)
    Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may ...
  • Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds 

    Virginia Tech Intellectual Properties, Inc.; Davalos, Rafael V.; Sano, Michael B.; Garcia, Paulo A.; Robertson, John L.; Neal, II, Robert E. (United States Patent and Trademark Office, 2018-01-16)
    The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation ...
  • Hybrid detector modules and dynamic thresholding for spectral CT 

    Virginia Tech Intellectual Properties, Inc.; Wang, Ge; Cong, Wenxiang; Chu, Jiyang (United States Patent and Trademark Office, 2018-01-09)
    A system and method that comprises an X-ray source configured to emit an X-ray beam; an object positioned to receive the X-ray beam; a detector configured to receive an attenuated beam of the X-rays through the object for ...
  • Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor 

    Rivas, Felipe; Zahid, Osama K.; Reesink, Heidi L.; Peal, Bridgette T.; Nixon, Alan J.; DeAngelis, Paul L.; Skardal, Aleksander; Rahbar, Elaheh; Hall, Adam R. (Springer Nature, 2018-03-12)
    Hyaluronan (or hyaluronic acid, HA) is a ubiquitous molecule that plays critical roles in numerous physiological functions in vivo, including tissue hydration, inflammation, and joint lubrication. Both the abundance and ...
  • High-Frequency Irreversible Electroporation for Intracranial Meningioma: A Feasibility Study in a Spontaneous Canine Tumor Model 

    Latouche, Eduardo L.; Arena, Christopher B.; Ivey, Jill W.; Garcia, Paulo A.; Pancotto, Theresa E.; Pavlisko, Noah; Verbridge, Scott; Davalos, Rafael V.; Rossmeisl, John H. (Sage, 2018)
    High-frequency irreversible electroporation is a nonthermal method of tissue ablation that uses bursts of 0.5- to 2.0-microsecond bipolar electric pulses to permeabilize cell membranes and induce cell death. High-frequency ...
  • Activation of bacterial channel MscL in mechanically stimulated droplet interface bilayers 

    Najem, Joseph S.; Dunlap, Myles D.; Rowe, Ian D.; Freeman, Eric C.; Grant, John W.; Sukharev, Sergei; Leo, Donald J. (Springer Nature, 2015-09-08)
    MscL, a stretch-activated channel, saves bacteria experiencing hypo-osmotic shocks from lysis. Its high conductance and controllable activation makes it a strong candidate to serve as a transducer in stimuli-responsive ...
  • A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease 

    Gilmore, Brian L.; Winton, Carly E.; Demmert, Andrew C.; Tanner, Justin R.; Bowman, Sam; Karageorge, Vasilea; Patel, Kaya; Sheng, Zhi; Kelly, Deborah F. (Springer Nature, 2015-09-23)
    We present a new molecular toolkit to investigate protein assemblies natively formed in the context of human disease. The system employs tunable microchips that can be decorated with switchable adaptor molecules to select ...
  • Adsorbing/dissolving Lyoprotectant Matrix Technology for Non-cryogenic Storage of Archival Human Sera 

    Solivio, Morwena J.; Less, Rebekah; Rynes, Mathew L.; Kramer, Marcus; Aksan, Alptekin (Springer Nature, 2016-04-12)
    Despite abundant research conducted on cancer biomarker discovery and validation, to date, less than two-dozen biomarkers have been approved by the FDA for clinical use. One main reason is attributed to inadvertent use of ...
  • Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores 

    Zahid, Osama K.; Zhao, Boxuan Simen; He, Chuan; Hall, Adam R. (Springer Nature, 2016-07-07)
    5-hydroxymethylcytosine (5 hmC), the oxidized form of 5-methylcytosine (5 mC), is a base modification with emerging importance in biology and disease. However, like most epigenetic elements, it is transparent to many ...
  • Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform 

    Skardal, Aleksander; Murphy, Sean V.; Devarasetty, Mahesh; Mead, Ivy; Kang, Hyun-Wook; Seol, Young-Joon; Zhang, Yu Shrike; Shin, Su-Ryon; Zhao, Liang; Aleman, Julio; Hall, Adam R.; Shupe, Thomas D.; Kleensang, Andre; Dokmeci, Mehmet R.; Lee, Sang Jin; Jackson, John D.; Yoo, James J.; Hartung, Thomas; Khademhosseini, Ali; Soker, Shay; Bishop, Colin E.; Atala, Anthony (Springer Nature, 2017-08-18)
    Many drugs have progressed through preclinical and clinical trials and have been available - for years in some cases -before being recalled by the FDA for unanticipated toxicity in humans. One reason for such poor translation ...
  • In vitro patient-derived 3D mesothelioma tumor organoids facilitate patient-centric therapeutic screening 

    Mazzocchi, Andrea R.; Rajan, Shiny A. P.; Votanopoulos, Konstantinos I.; Hall, Adam R.; Skardal, Aleksander (Springer Nature, 2018-02-13)
    Variability in patient response to anti-cancer drugs is currently addressed by relating genetic mutations to chemotherapy through precision medicine. However, practical benefits of precision medicine to therapy design are ...
  • Transcriptomic Analysis of Hepatic Cells in Multicellular Organotypic Liver Models 

    Tegge, Allison N.; Rodrigues, Richard R.; Larkin, Adam L.; Vu, Lucas; Murali, T. M.; Rajagopalan, Padmavathy (Springer Nature, 2018-07-27)
    Liver homeostasis requires the presence of both parenchymal and non-parenchymal cells (NPCs). However, systems biology studies of the liver have primarily focused on hepatocytes. Using an organotypic three-dimensional (3D) ...
  • 3D Bioprinted Human Skeletal Muscle Constructs for Muscle Function Restoration 

    Kim, Ji Hyun; Seol, Young-Joon; Ko, In Kap; Kang, Hyun-Wook; Lee, Young Koo; Yoo, James J.; Atala, Anthony; Lee, Sang Jin (Springer Nature, 2018-08-17)
    A bioengineered skeletal muscle tissue as an alternative for autologous tissue flaps, which mimics the structural and functional characteristics of the native tissue, is needed for reconstructive surgery. Rapid progress ...
  • Tumor Ablation with Irreversible Electroporation 

    Al-Sakere, Bassim; Andre, Franck; Bernat, Claire; Connault, Elisabeth; Opolon, Paule; Davalos, Rafael V.; Rubinsky, Boris; Mir, Lluis M. (PLOS, 2007-11-07)
    We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ...
  • Folic Acid-Conjugated Cellulose Nanocrystals Show High Folate-Receptor Binding Affinity and Uptake by KB and Breast Cancer Cells 

    Bittleman, Katelyn Rose; Dong, Shuping; Roman, Maren; Lee, Yong Woo (American Chemical Society, 2018-10-24)
    The study evaluates cellulose nanocrystals (CNCs) as nanocarriers for targeted, intracellular delivery of molecular agents. CNCs were labeled with fluorescein-5′-isothiocyanate as an imaging agent and conjugated to folic ...

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