Scholarly Works, School of Biomedical Engineering and Sciences
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Research articles, presentations, and other scholarship
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Characterization and structure-property relationships of an injectable thiol-Michael addition hydrogel toward compatibility with glioblastoma therapy
(Elsevier, 2022-05-01)Glioblastoma multiforme (GBM) is an aggressive primary brain cancer and although patients undergo surgery and chemoradiotherapy, residual cancer cells still migrate to healthy brain tissue and lead to tumor relapse after ... -
Electroresponsive Hydrogels for Therapeutic Applications in the Brain
(Wiley, 2021-12-01)Electroresponsive hydrogels possess a conducting material component and respond to electric stimulation through reversible absorption and expulsion of water. The high level of hydration, soft elastomeric compliance, ... -
In-Season Concussion Symptom Reporting in Male and Female Collegiate Rugby Athletes
(2021-11-01)Symptom inventories are generally only collected after a suspected concussion, but regular in-season monitoring may allude to clinical symptoms associated with repetitive subconcussive impacts and potential undiagnosed ... -
Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer
(Cell Press, 2020-12-18)Recent studies have begun to highlight the diverse and tumor-specific microbiomes across multiple cancer types. We believe this work raises the important question of whether the classical “Hallmarks of Cancer” should be ... -
Opponent Effects of Hyperarousal and Re-experiencing on Affective Habituation in Posttraumatic Stress Disorder
(2020-02)BACKGROUND: Aberrant emotion processing is a hallmark of posttraumatic stress disorder (PTSD), with neurobiological models suggesting both heightened neural reactivity and diminished habituation to aversive stimuli. However, ... -
Characterization of multicellular breast tumor spheroids using image data-driven biophysical mathematical modeling
(2020-07-14)Multicellular tumor spheroid (MCTS) systems provide an in vitro cell culture model system which mimics many of the complexities of an in vivo solid tumor and tumor microenvironment, and are often used to study cancer cell ... -
Characterization of Ablation Thresholds for 3D-Cultured Patient-Derived Glioma Stem Cells in Response to High-Frequency Irreversible Electroporation
(American Association for the Advancement of Science, 2019-04-28)High-frequency irreversible electroporation (H-FIRE) is a technique that uses pulsed electric fields that have been shown to ablate malignant cells. In order to evaluate the clinical potential of H-FIRE to treat glioblastoma ... -
Cytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapies
(MDPI, 2020-04-30)Pulsed electric fields (PEFs) have become clinically important through the success of Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs (nsPEFs) for the treatment of tumors. PEFs increase ... -
Data-driven statistical modeling of the emergent behavior of biohybrid microrobots
(2020-03-01)Multi-agent biohybrid microrobotic systems, owing to their small size and distributed nature, offer powerful solutions to challenges in biomedicine, bioremediation, and biosensing. Synthetic biology enables programmed ... -
The assembly of integrated rat intestinal-hepatocyte cultures
(2019-11)The jejunum is the segment of the small intestine responsible for several metabolism and biotransformation functions. In this report, we have cultured rat jejunum explants in vitro and integrated them with hepatocyte ... -
Real-time prediction of patient immune cell modulation during irreversible electroporation therapy
(2019-11-28)Immunotherapies have demonstrated limited efficacy in pancreatic ductal adenocarcinoma (PDAC) patients despite their success in treating other tumor types. This limitation is largely due to the relatively immunosuppressive ... -
Fabrication and Characterization of Three Dimensional Electrospun Cortical Bone Scaffolds
(De Gruyter Open, 2014)Bone is a composite tissue composed of an organic matrix, inorganic mineral matrix and water. Structurally, bone is organized into two distinct types: trabecular (or cancellous) and cortical (or compact) bone. Cortical ... -
Temporal Characterization of Blood–Brain Barrier Disruption with High-Frequency Electroporation
(MDPI, 2019-11-23)Treatment of intracranial disorders suffers from the inability to accumulate therapeutic drug concentrations due to protection from the blood–brain barrier (BBB). Electroporation-based therapies have demonstrated the ... -
TNF alpha Modulates Cardiac Conduction by Altering Electrical Coupling between Myocytes
(Frontiers, 2017-05-23)Background: Tumor Necrosis Factor alpha (TNF alpha) upregulation during acute inflammatory response has been associated with numerous cardiac effects including modulating Connexin43 and vascular permeability. This may in ... -
Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part III: Irreversible Electroporation and High-Frequency Irreversible Electroporation for the Eradication of Glioblastoma
(2017)Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Approximately 9180 primary GBM tumors are diagnosed in the United States each year, in which median survival is up to 16 months. GBM eludes ... -
Nanonet force microscopy for measuring forces in single smooth muscle cells of the human aorta
(2017-07-07)A number of innovative methods exist to measure cell-matrix adhesive forces, but they have yet to accurately describe and quantify the intricate interplay of a cell and its fibrous extracellular matrix (ECM). In cardiovascular ... -
Aligned fibers direct collective cell migration to engineer closing and nonclosing wound gaps
(2017-09-15)Cell emergence onto damaged or organized fibrous extracellular matrix (ECM) is a crucial precursor to collective cell migration in wound closure and cancer metastasis, respectively. However, there is a fundamental gap in ... -
In Situ Bioprinting of Autologous Skin Cells Accelerates Wound Healing of Extensive Excisional Full-Thickness Wounds
(Springer Nature, 2019-02-21)The early treatment and rapid closure of acute or chronic wounds is essential for normal healing and prevention of hypertrophic scarring. The use of split thickness autografts is often limited by the availability of a ... -
Is sham cTBS real cTBS? The effect on EEG dynamics
(Frontiers Media S.A., 2015-01-08)Increasing sensitivity of modern evaluation tools allows for the study of weaker electric stimulation effects on neural populations. In the current study we examined the effects of sham continuous theta burst (cTBS) ... -
A Stationary-Sources and Rotating-Detectors Computed Tomography Architecture for Higher Temporal Resolution and Lower Radiation Dose
(IEEE, 2014)In current computed tomography (CT) architecture, both X-ray tubes and X-ray detectors are rotated mechanically around an object to collect a sufficient number of projections. This architecture has been shown to not be ...
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