Browsing Scholarly Works, School of Biomedical Engineering and Sciences by Title
Now showing items 80-99 of 132
-
Mitigation of impedance changes due to electroporation therapy using bursts of high-frequency bipolar pulses
(2015-08-27)Background For electroporation-based therapies, accurate modeling of the electric field distribution within the target tissue is important for predicting the treatment volume. In response to conventional, unipolar pulses, ... -
Molecular Analysis of BRCA1 in Human Breast Cancer Cells Under Oxidative Stress
(Nature Publishing Group, 2017-03-06)The precise manner in which physical changes to the breast cancer susceptibility protein (BRCA1) affect its role in DNA repair events remain unclear. Indeed, cancer cells harboring mutations in BRCA1 suffer from genomic ... -
A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease
(Springer Nature, 2015-09-23)We present a new molecular toolkit to investigate protein assemblies natively formed in the context of human disease. The system employs tunable microchips that can be decorated with switchable adaptor molecules to select ... -
Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform
(Springer Nature, 2017-08-18)Many drugs have progressed through preclinical and clinical trials and have been available - for years in some cases -before being recalled by the FDA for unanticipated toxicity in humans. One reason for such poor translation ... -
N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: Implications for breast cancer viability and proliferation in vitro
(PLOS, 2017-07-10)It is well documented that the tumor microenvironment profoundly impacts the etiology and progression of breast cancer, yet the contribution of the resident microbiome within breast tissue remains poorly understood. Tumor ... -
Nanonet force microscopy for measuring forces in single smooth muscle cells of the human aorta
(2017-07-07)A number of innovative methods exist to measure cell-matrix adhesive forces, but they have yet to accurately describe and quantify the intricate interplay of a cell and its fibrous extracellular matrix (ECM). In cardiovascular ... -
Neural computations underlying social risk sensitivity
(Frontiers, 2012-08-02)Under standard models of expected utility, preferences over stochastic events are assumed to be independent of the source of uncertainty. Thus, in decision-making, an agent should exhibit consistent preferences, regardless ... -
Non-Invasive Detection of Respiration and Heart Rate with a Vehicle Seat Sensor
(MDPI, 2018-05-08)This study demonstrates the feasibility of using a seat sensor designed for occupant classification from a production passenger vehicle to measure an occupant’s respiration rate (RR) and heart rate (HR) in a laboratory ... -
Nonlinear Elasto-Mammography for Characterization of Breast Tissue Properties
(Hindawi, 2011-12-22)Quantification of the mechanical behavior of normal and cancerous tissues has important implication in the diagnosis of breast tumor. The present work extends the authors' nonlinear elastography framework to incorporate ... -
A novel frequency analysis method for assessing K(ir)2.1 and Na (v)1.5 currents.
(2012-04)Voltage clamping is an important tool for measuring individual currents from an electrically active cell. However, it is difficult to isolate individual currents without pharmacological or voltage inhibition. Herein, we ... -
A Numerical Investigation of the Electric and Thermal Cell Kill Distributions in Electroporation-Based Therapies in Tissue
(PLOS, 2014-08-12)Electroporation-based therapies are powerful biotechnological tools for enhancing the delivery of exogeneous agents or killing tissue with pulsed electric fields (PEFs). Electrochemotherapy (ECT) and gene therapy based on ... -
Opponent Effects of Hyperarousal and Re-experiencing on Affective Habituation in Posttraumatic Stress Disorder
(2020-02)BACKGROUND: Aberrant emotion processing is a hallmark of posttraumatic stress disorder (PTSD), with neurobiological models suggesting both heightened neural reactivity and diminished habituation to aversive stimuli. However, ... -
Optimizing the restored chemotactic behavior of anticancer agent Salmonella enterica serovar Typhimurium VNP20009
(Elsevier, 2017-06-10)Bacteria, including strains of Salmonella, have been researched and applied as therapeutic cancer agents for centuries. Salmonella are particularly of interest due to their facultative anaerobic nature, facilitating ... -
A Parametric Study Delineating Irreversible Electroporation from Thermal Damage Based on a Minimally Invasive Intracranial Procedure
(2011-04-30)Background Irreversible electroporation (IRE) is a new minimally invasive technique to kill undesirable tissue in a non-thermal manner. In order to maximize the benefits from an IRE procedure, the pulse parameters and ... -
Pathology of non-thermal irreversible electroporation (N-TIRE)-induced ablation of the canine brain
(Korean Society of Veterinary Science, 2013-12-01)This study describes the neuropathologic features of normal canine brain ablated with non-thermal irreversible electroporation (N-TIRE). The parietal cerebral cortices of four dogs were treated with N-TIRE using a ... -
Performance enhancement of piezoelectric energy harvesters from wake galloping
(AIP Publishing, 2013-07-01)Experiments are performed to investigate the effects of wake galloping on the range of flow speeds over which a galloping-based piezoaeroelastic energy harvester can be effectively used. Two different upstream cylinders ... -
Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma
(Wiley, 2017-07-25)Purpose: Irreversible electroporation (IRE) has been developed as a promising minimally invasive treatment to ablate spontaneous brain tumors with pulsed electric fields in canine patients. The purpose of the study is to ... -
Preferred Placement and Usability of a Smart Textile System vs. Inertial Measurement Units for Activity Monitoring
(MDPI, 2018-08-01)Wearable sensors and systems have become increasingly popular in recent years. Two prominent wearable technologies for human activity monitoring are smart textile systems (STSs) and inertial measurement units (IMUs). Despite ... -
Pulsed Ultrasound Differentially Stimulates Somatosensory Circuits in Humans as Indicated by EEG and fMRI
(PLOS, 2012-12-04)Peripheral somatosensory circuits are known to respond to diverse stimulus modalities. The energy modalities capable of eliciting somatosensory responses traditionally belong to mechanical, thermal, electromagnetic, and ... -
Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores
(Springer Nature, 2016-07-07)5-hydroxymethylcytosine (5 hmC), the oxidized form of 5-methylcytosine (5 mC), is a base modification with emerging importance in biology and disease. However, like most epigenetic elements, it is transparent to many ...
