Where conceptual and technological constraints once forced researchers to examine living systems one small slice at a time, we can now find complex connections ranging from the basic building blocks of life to public policy. The Biocomplexity Institute of Virginia Tech is at the forefront of this scientific evolution, applying a deeply contextual approach to answer some of the most pressing challenges to human health, habitat, and well-being. Our research is interdisciplinary to its core, integrating methods from the life, cognitive, and social sciences, as well environmental studies and infrastructural development. The institute guides emergency response to epidemics, makes urban infrastructure more sustainable, and accelerates the discovery of treatments for chronic diseases. We are pioneers in biocomplexity, the study of life and environment as a complex system. A biocomplexity approach analyzes the interactions between many simple components that combine to produce significant effects on the macro scale. By understanding biology in the context of ecosystems and human-created systems that interact on many levels, we are able to uncover powerful connections between healthcare, security, information networks, and infrastructure.

Note: The Biocomplexity Institute was formerly named the Virginia Bioinformatics Institute (VBI).

Sub-communities within this community

  • Virginia Tech Center for Drug Discovery [19]

    An interdisciplinary group committed to continuing the growth and advancing the stature of the existing drug discovery and development programs at Virginia Tech.

Collections in this community

Recent Submissions

  • Comparative mangrove metagenome reveals global prevalence of heavy metals and antibiotic resistome across different ecosystems 

    Imchen, Madangchanok; Kumavath, Ranjith; Barh, Debmalya; Vaz, Aline; Goes-Neto, Aristoteles; Tiwari, Sandeep; Ghosh, Preetam; Wattam, Alice R.; Azevedo, Vasco (Springer Nature, 2018-07-25)
    The mangrove ecosystem harbors a complex microbial community that plays crucial role in biogeochemical cycles. In this study, we analyzed mangrove sediments from India using de novo whole metagenome next generation sequencing ...
  • A virtual look at Epstein-Barr virus infection: Biological interpretations 

    Duca, Karen A.; Shapiro, Michael; Delgado-Eckert, Edgar; Hadinoto, Vey; Jarrah, Abdul S.; Laubenbacher, Reinhard; Lee, Kichol; Luzuriaga, Katherine; Polys, Nicholas F.; Thorley-Lawson, David A. (PLOS, 2007-10-19)
    The possibility of using computer simulation and mathematical modeling to gain insight into biological and other complex systems is receiving increased attention. However, it is as yet unclear to what extent these techniques ...
  • Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond 

    Van Voorhis, Wesley C.; Adams, John H.; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H.; Alano, Pietro; Alday, Aintzane; Resto, Yesmalie Aleman; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T.; Avery, Simon V.; Avery, Vicky M.; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; Bowling, Tana; Bosch, Juergen; Boucher, Lauren E.; Boyom, Fabrice F.; Brea, Jose; Brennan, Marian; Burton, Audrey; Caffrey, Conor R.; Camarda, Grazia; Carrasquilla, Manuela; Carter, Dee; Cassera, Maria Belen; Cheng, Ken Chih-Chien; Chindaudomsate, Worathad; Chubb, Anthony; Colon, Beatrice L.; Colon-Lopez, Daisy D.; Corbett, Yolanda; Crowther, Gregory J.; Cowan, Noemi; D'Alessandro, Sarah; Le Dang, Na; Delves, Michael; DeRisi, Joseph L.; Du, Alan Y.; Duffy, Sandra; El-Sayed, Shimaa Abd El-Salam; Ferdig, Michael T.; Robledo, Jose A. Fernandez; Fidock, David A.; Florent, Isabelle; Fokou, Patrick V. T.; Galstian, Ani; Javier Gamo, Francisco; Gokool, Suzanne; Gold, Ben; Golub, Todd; Goldgof, Gregory M.; Guha, Rajarshi; Guiguemde, W. Armand; Gural, Nil; Guy, R. Kiplin; Hansen, Michael A. E.; Hanson, Kirsten K.; Hemphill, Andrew; van Huijsduijnen, Rob Hooft; Horii, Takaaki; Horrocks, Paul; Hughes, Tyler B.; Huston, Christopher; Igarashi, Ikuo; Ingram-Sieber, Katrin; Itoe, Maurice A.; Jadhav, Ajit; Jensen, Amornrat Naranuntarat; Jensen, Laran T.; Jiang, Rays H. Y.; Kaiser, Annette; Keiser, Jennifer; Ketas, Thomas; Kicka, Sebastien; Kim, Sunyoung; Kirk, Kiaran; Kumar, Vidya P.; Kyle, Dennis E.; Jose Lafuente, Maria; Landfear, Scott; Lee, Nathan; Lee, Sukjun; Lehane, Adele M.; Li, Fengwu; Little, David; Liu, Liqiong; Llinas, Manuel; Loza, Maria I.; Lubar, Aristea; Lucantoni, Leonardo; Lucet, Isabelle; Maes, Louis; Mancama, Dalu; Mansour, Nuha R.; March, Sandra; McGowan, Sheena; Vera, Iset Medina; Meister, Stephan; Mercer, Luke; Mestres, Jordi; Mfopa, Alvine N.; Misra, Raj N.; Moon, Seunghyun; Moore, John P.; Rodrigues da Costa, Francielly Morais; Mueller, Joachim; Muriana, Arantza; Hewitt, Stephen Nakazawa; Nare, Bakela; Nathan, Carl; Narraidoo, Nathalie; Nawaratna, Sujeevi; Ojo, Kayode K.; Ortiz, Diana; Panic, Gordana; Papadatos, George; Parapini, Silvia; Patra, Kailash; Ngoc Pham; Prats, Sarah; Plouffe, David M.; Poulsen, Sally-Ann; Pradhan, Anupam; Quevedo, Celia; Quinn, Ronald J.; Rice, Christopher A.; Rizk, Mohamed Abdo; Ruecker, Andrea; St Onge, Robert; Ferreira, Rafaela Salgado; Samra, Jasmeet; Robinett, Natalie G.; Schlecht, Ulrich; Schmitt, Marjorie; Villela, Filipe Silva; Silvestrini, Francesco; Sinden, Robert; Smith, Dennis A.; Soldati, Thierry; Spitzmueller, Andreas; Stamm, Serge Maximilian; Sullivan, David J.; Sullivan, William; Suresh, Sundari; Suzuki, Brian M.; Suzuki, Yo; Swamidass, S. Joshua; Taramelli, Donatella; Tchokouaha, Lauve R. Y.; Theron, Anjo; Thomas, David; Tonissen, Kathryn F.; Townson, Simon; Tripathi, Abhai K.; Trofimov, Valentin; Udenze, Kenneth O.; Ullah, Imran; Vallieres, Cindy; Vigil, Edgar; Vinetz, Joseph M.; Phat Voong Vinh; Hoan Vu; Watanabe, Nao-aki; Weatherby, Kate; White, Pamela M.; Wilks, Andrew F.; Winzeler, Elizabeth A.; Wojcik, Edward; Wree, Melanie; Wu, Wesley; Yokoyama, Naoaki; Zollo, Paul H. A.; Abla, Nada; Blasco, Benjamin; Burrows, Jeremy; Laleu, Benoit; Leroy, Didier; Spangenberg, Thomas; Wells, Timothy; Willis, Paul A. (PLOS, 2016-07-28)
    A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of ...
  • Reconstruction of endosomal organization and function by a combination of ODE and agent-based modeling strategies 

    Mayorga, Luis S; Cebrian, Ignacio; Verma, Meghna; Hoops, Stefan; Bassaganya-Riera, Josep (2018-11-23)
    Abstract Background Reproducing cell processes using an in silico system is an essential tool for understanding the underlying mechanisms and emergent properties of this ...
  • EpiViewer: an epidemiological application for exploring time series data 

    Thorve, Swapna; Wilson, Mandy L.; Lewis, Bryan L.; Swarup, Samarth; Vullikanti, Anil Kumar S.; Marathe, Madhav V. (2018-11-22)
    Abstract Background Visualization plays an important role in epidemic time series analysis and forecasting. Viewing time series data plotted on a graph can help researchers ...
  • Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells 

    Luo, Yanting; He, Jianlin; Xu, Xiguang; Sun, Ming-an; Wu, Xiaowei; Lu, Xuemei; Xie, Hehuang (PLOS, 2018-03)
    Embryonic stem cells (ESCs) consist of a population of self-renewing cells displaying extensive phenotypic and functional heterogeneity. Research towards the understanding of the epigenetic mechanisms underlying the ...
  • A Stochastic Model of the Yeast Cell Cycle Reveals Roles for Feedback Regulation in Limiting Cellular Variability 

    Barik, Debashis; Ball, David A.; Peccoud, Jean; Tyson, John J. (PLOS, 2016-12)
    The cell division cycle of eukaryotes is governed by a complex network of cyclin-dependent protein kinases (CDKs) and auxiliary proteins that govern CDK activities. The control system must function reliably in the context ...
  • Plasmids and Rickettsial Evolution: Insight from Rickettsia felis 

    Gillespie, Joseph J.; Beier, Magda S.; Rahman, M. Sayeedur; Ammerman, Nicole C.; Shallom, Joshua M.; Purkayastha, Anjan; Sobral, Bruno S.; Azad, Abdu F. (PLOS, 2007-03-07)
    Background The genome sequence of Rickettsia felis revealed a number of rickettsial genetic anomalies that likely contribute not only to a large genome size relative to other rickettsiae, but also to phenotypic oddities ...
  • Burst of Young Retrogenes and Independent Retrogene Formation in Mammals 

    Pan, Deng; Zhang, Liqing (PLOS, 2009-03-27)
    Retroposition and retrogenes gain increasing attention as recent studies show that they play an important role in human new gene formation. Here we examined the patterns of retrogene distribution in 8 mammalian genomes ...
  • Simulations of Tubulin Sheet Polymers as Possible Structural Intermediates in Microtubule Assembly 

    Wu, Zhanghan; Wang, Hong-Wei; Mu, Weihua; Ouyang, Zhongcan; Nogales, Eva; Xing, Jianhua (PLOS, 2009-10-02)
    The microtubule assembly process has been extensively studied, but the underlying molecular mechanism remains poorly understood. The structure of an artificially generated sheet polymer that alternates two types of lateral ...
  • An Atlas of the Speed of Copy Number Changes in Animal Gene Families and Its Implications 

    Pan, Deng; Zhang, Liqing (PLOS, 2009-10-23)
    The notion that gene duplications generating new genes and functions is commonly accepted in evolutionary biology. However, this assumption is more speculative from theory rather than well proven in genome-wide studies. ...
  • Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells 

    Chen, Qinghe; Ganapathy, Suthakar; Singh, Karan P.; Shankar, Sharmila; Srivastava, Rakesh K. (PLOS, 2010-12-14)
    Background Resveratrol, a naturally occurring phytopolyphenol compound, has attracted extensive interest in recent years because of its diverse pharmacological characteristics. Although resveratrol possesses chemopreventive ...
  • Resveratrol Enhances Antitumor Activity of TRAIL in Prostate Cancer Xenografts through Activation of FOXO Transcription Factor 

    Ganapathy, Suthakar; Chen, Qinghe; Singh, Karan P.; Shankar, Sharmila; Srivastava, Rakesh K. (PLOS, 2010-12-28)
    Background Resveratrol (3, 4′, 5 tri-hydroxystilbene), a naturally occurring polyphenol, exhibits anti-inflammatory, antioxidant, cardioprotective and antitumor activities. We have recently shown that resveratrol can ...
  • Identification of a Common Lupus Disease-Associated microRNA Expression Pattern in Three Different Murine Models of Lupus 

    Dai, Rujuan; Zhang, Yan; Khan, Deena; Heid, Bettina; Caudell, David; Crasta, Oswald; Ahmed, S. Ansar (PLOS, 2010-12-10)
    Background Recent reports have shown that microRNAs (miRNAs) regulate vital immunological processes and have emerged as key regulators of immune system development and function. Therefore, it is important to determine ...
  • Discovering Networks of Perturbed Biological Processes in Hepatocyte Cultures 

    Lasher, Christopher D.; Rajagopalan, Padmavathy; Murali, T. M. (PLOS, 2011-01-05)
    The liver plays a vital role in glucose homeostasis, the synthesis of bile acids and the detoxification of foreign substances. Liver culture systems are widely used to test adverse effects of drugs and environmental ...
  • Prediction of Disease and Phenotype Associations from Genome-Wide Association Studies 

    Lewis, Stephanie N.; Nsoesie, Elaine; Weeks, Charles; Qiao, Dan; Zhang, Liqing (PLOS, 2011-11-04)
    Background Genome wide association studies (GWAS) have proven useful as a method for identifying genetic variations associated with diseases. In this study, we analyzed GWAS data for 61 diseases and phenotypes to elucidate ...
  • Feature selection of gene expression data for Cancer classification using double RBF-kernels 

    Liu, Shenghui; Xu, Chunrui; Zhang, Yusen; Liu, Jiaguo; Yu, Bin; Liu, Xiaoping; Dehmer, Matthias (2018-10-29)
    Abstract Background Using knowledge-based interpretation to analyze omics data can not only obtain essential information regarding various biological processes, but also reflect ...
  • Identification of Early Zygotic Genes in the Yellow Fever Mosquito Aedes aegypti and Discovery of a Motif Involved in Early Zygotic Genome Activation 

    Biedler, James K.; Hu, Wanqi; Tae, Hongseok; Tu, Zhijian (PLOS, 2012-03-23)
    During early embryogenesis the zygotic genome is transcriptionally silent and all mRNAs present are of maternal origin. The maternal-zygotic transition marks the time over which embryogenesis changes its dependence from ...
  • A Method for Comparing Multivariate Time Series with Different Dimensions 

    Tapinos, Avraam; Mendes, Pedro (PLOS, 2013-02-05)
    In many situations it is desirable to compare dynamical systems based on their behavior. Similarity of behavior often implies similarity of internal mechanisms or dependency on common extrinsic factors. While there are ...
  • Metagenomic Analysis of a Tropical Composting Operation at the Sao Paulo Zoo Park Reveals Diversity of Biomass Degradation Functions and Organisms 

    Martins, Layla Farage; Antunes, Luciana Principal; Pascon, Renata C.; Franco de Oliveira, Julio Cezar; Digiampietri, Luciano A.; Barbosa, Deibs; Peixoto, Bruno Malveira; Vallim, Marcelo A.; Viana-Niero, Cristina; Ostroski, Eric H.; Telles, Guilherme P.; Dias, Zanoni; da Cruz, Joao Batista; Juliano, Luiz; Verjovski-Almeida, Sergio; da Silva, Aline Maria; Setubal, Joao Carlos (PLOS, 2013-04-24)
    Composting operations are a rich source for prospection of biomass degradation enzymes. We have analyzed the microbiomes of two composting samples collected in a facility inside the São Paulo Zoo Park, in Brazil. All organic ...

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