Now showing items 1-6 of 6
JigCell Run Manager (JC-RM): a tool for managing large sets of biochemical model parametrizations
(Biomed Central Ltd, 2015-12-24)
Background Most biomolecular reaction modeling tools allow users to build models with a single list of parameter values. However, a common scenario involves different parameterizations of the model to account for the ...
A simple theoretical framework for understanding heterogeneous differentiation of CD4(+) T cells
(Biomed Central Ltd, 2012-06-14)
Background CD4+ T cells have several subsets of functional phenotypes, which play critical yet diverse roles in the immune system. Pathogen-driven differentiation of these subsets of cells is often heterogeneous in terms ...
Multistate Model Builder (MSMB): a flexible editor for compact biochemical models
(Biomed Central Ltd, 2014-04-04)
Background Building models of molecular regulatory networks is challenging not just because of the intrinsic difficulty of describing complex biological processes. Writing a model is a creative effort that calls for more ...
Temporal Controls of the Asymmetric Cell Division Cycle in Caulobacter crescentus
The asymmetric cell division cycle of Caulobacter crescentus is orchestrated by an elaborate gene-protein regulatory network, centered on three major control proteins, DnaA, GcrA and CtrA. The regulatory network is cast ...
Potential Role of a Bistable Histidine Kinase Switch in the Asymmetric Division Cycle of Caulobacter crescentus
The free-living aquatic bacterium, Caulobacter crescentus, exhibits two different morphologies during its life cycle. The morphological change from swarmer cell to stalked cell is a result of changes of function of two ...