ICTAS Vision: To be a premier institute to advance transformative, interdisciplinary research for a sustainable future. ICTAS Mission: To serve Virginia Tech, the Commonwealth of Virginia, the nation, and the world through high-impact research and scholarship at the intersections of engineering, the sciences -- physical, life, and social -- and the humanities. To this end, advance the frontiers of knowledge and education, enhance the educational experience of undergraduate, graduate, and professional students, and promote economic development through the creation and application of innovative research that enhances the quality of life and preserves our natural resources.

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  • Establishing an immunocompromised porcine model of human cancer for novel therapy development with pancreatic adenocarcinoma and irreversible electroporation 

    Hendricks-Wenger, Alissa; Aycock, Kenneth N.; Nagai-Singer, Margaret A.; Coutermarsh-Ott, Sheryl; Lorenzo, Melvin F.; Gannon, Jessica; Uh, Kyungjun; Farrell, Kayla; Beitel-White, Natalie; Brock, Rebecca M.; Simon, Alexander; Morrison, Holly A.; Tuohy, Joanne; Clark-Deener, Sherrie; Vlaisavljevich, Eli; Davalos, Rafael; Lee, Kiho; Allen, Irving C. (Nature Research, 2021-04-07)
    New therapies to treat pancreatic cancer are direly needed. However, efficacious interventions lack a strong preclinical model that can recapitulate patients’ anatomy and physiology. Likewise, the availability of human ...
  • Bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic or artificial cavitation nuclei 

    Edsall, Connor; Khan, Zerin Mahzabin; Mancia, Lauren; Hall, Sarah; Mustafa, Waleed; Johnsen, Eric; Klibanov, Alexander L.; Durmaz, Yasemin Yuksel; Vlaisavljevich, Eli (2021-03)
    The study described here examined the effects of cavitation nuclei characteristics on histotripsy. High-speed optical imaging was used to compare bubble cloud behavior and ablation capacity for histotripsy generated from ...
  • 3D printed graphene-based self-powered strain sensors for smart tires in autonomous vehicles 

    Maurya, Deepam; Khaleghian, Seyedmeysam; Sriramdas, Rammohan; Kumar, Prashant; Kishore, Ravi Anant; Kang, Min Gyu; Kumar, Vireshwar; Song, Hyun-Cheol; Lee, Seul-Yi; Yan, Yongke; Park, Jung-Min; Taheri, Saied; Priya, Shashank (2020-10-26)
    The transition of autonomous vehicles into fleets requires an advanced control system design that relies on continuous feedback from the tires. Smart tires enable continuous monitoring of dynamic parameters by combining ...
  • The PathLinker app: Connect the dots in protein interaction networks 

    Gil, Daniel P.; Law, Jeffrey N.; Murali, T. M. (F1000Research, 2017-01-20)
    PathLinker is a graph-theoretic algorithm for reconstructing the interactions in a signaling pathway of interest. It efficiently computes multiple short paths within a background protein interaction network from the receptors ...
  • Automating the PathLinker app for Cytoscape 

    Huang, Li Jun; Law, Jeffrey N.; Murali, T. M. (F1000Research, 2018-06-12)
    PathLinker is a graph-theoretic algorithm originally developed to reconstruct the interactions in a signaling pathway of interest. It efficiently computes multiple short paths within a background protein interaction network ...
  • Connectivity Measures for Signaling Pathway Topologies 

    Franzese, Nicholas; Groce, Adam; Murali, T. M.; Ritz, Anna (Virginia Tech, 2019-03-30)
    Characterizing cellular responses to different extrinsic signals is an active area of research, and curated pathway databases describe these complex signaling reactions. Here, we revisit a fundamental question in signaling ...
  • Antibacterial efficacy of core-shell nanostructures encapsulating gentamicin against an in vivo intracellular Salmonella model 

    Ranjan, Ashish; Pothayee, Nikorn; Seleem, Mohammed N.; Tyler, Ronald D.; Brenseke, Bonnie; Sriranganathan, Nammalwar; Riffle, Judy S.; Kasimanickam, Ramanathan (Dove Medical Press, 2009-01-01)
    Pluronic based core-shell nanostructures encapsulating gentamicin were designed in this study. Block copolymers of (PAA(+/-)Na-b-(PEO-b-PPO-b-PEO)-b-PAA(+/-)Na) were blended with PAA(-) Na(+) and complexed with the ...
  • Recent advances in understanding the terminal Ediacaran Earth-life system in South China and Arctic Siberia 

    Cui, H.; Kaufman, Alan J.; Xiao, S.; Grazhdankin, D. V.; Peek, S.; Martin, A. J.; Bykova, N. V.; Rogov, V. I.; Liu, X. M.; Zhang, F.; Romaniello, S. J.; Anbar, A. D.; Peng, Y.; Cai, Y.; Schiffbauer, J. D.; Meyer, M.; Gilleaudeau, Geoffrey J.; Plummer, Rebecca E.; Sievers, N. E.; Goderis, S.; Claeys, P. (2019-11-22)
    The terminal Ediacaran contains dramatic changes in biogeochemical cycles, many of which are closely coupled with evolutionary transitions in the corresponding fossil records. Dynamic redox conditions may have caused a ...
  • The assembly of integrated rat intestinal-hepatocyte cultures 

    Kothari, Anjaney; Rajagopala, Padmavathy (2019-11)
    The jejunum is the segment of the small intestine responsible for several metabolism and biotransformation functions. In this report, we have cultured rat jejunum explants in vitro and integrated them with hepatocyte ...
  • Abiotic synthesis of graphite in hydrothermal vents 

    Estes, Emily R.; Berti, Debora; Coffey, Nicole R.; Hochella, Michael F. Jr.; Wozniak, Andrew S.; Luther, George W. III (2019-11-15)
    Deciphering the origin, age, and composition of deep marine organic carbon remains a challenge in understanding the dynamics of the marine carbon cycle. In particular, the composition of aged organic carbon and what allows ...
  • Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function 

    McDaniel, Dylan K.; Ringel-Scaia, Veronica M.; Morrison, Holly A.; Coutermarsh-Ott, Sheryl; Council-Troche, McAlister; Angle, Jonathan W.; Perry, Justin B.; Davis, Grace; Leng, Weinan; Minarchick, Valerie; Yang, Yi; Chen, Bo; Reece, Sky W.; Brown, David A.; Cecere, Thomas E.; Brown, Jared M.; Gowdy, Kymberly M.; Hochella, Michael F. Jr.; Allen, Irving C. (Frontiers, 2019-11-28)
    Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious ...
  • Nanoparticulate Nickel-Hosting Phases in Sulfidic Environments: Effects of Ferrous Iron and Bacterial Presence on Mineral Formation Mechanism and Solid-Phase Nickel Distribution 

    Manson, Muammar; Winkler, Christopher; Hochella, Michael F. Jr.; Xu, Jie (Frontiers, 2019-06-26)
    The precipitation of nickel with sulfide is an important process governing the bioavailability of Ni in natural waters, and this process has the potential to effectively remove aqueous Ni contaminants in near-surface ...
  • Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory 

    Vance, Marina; Kuiken, Todd; Vejerano, Eric P.; McGinnis, Sean; Hochella, Michael F. Jr.; Rejeski, David; Hull, Matthew S. (Beilstein-Institut, 2015)
    To document the marketing and distribution of nano-enabled products into the commercial marketplace, the Woodrow Wilson International Center for Scholars and the Project on Emerging Nanotechnologies created the Nanotechnology ...
  • High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity 

    Ringel-Scaia, Veronica M.; Beitel-White, Natalie; Lorenzo, Melvin F.; Brock, Rebecca M.; Huie, Kathleen E.; Coutermarsh-Ott, Sheryl; Eden, Kristin; McDaniel, Dylan K.; Verbridge, Scott; Rossmeisl, John H. Jr.; Oestreich, Kenneth J.; Davalos, Rafael V.; Allen, Irving C. (2019-06)
    Background: Despite promising treatments for breast cancer, mortality rates remain high and treatments for metastatic disease are limited. High-frequency irreversible electroporation (H-FIRE) is a novel tumor ablation ...
  • Aerosol microdroplets exhibit a stable pH gradient 

    Wei, Haoran; Vejerano, Eric P.; Leng, Weinan; Huang, Qishen; Willner, Marjorie R.; Marr, Linsey C.; Vikesland, Peter J. (2018-07-10)
    Suspended aqueous aerosol droplets (< 50 mu m) are microreactors for many important atmospheric reactions. In droplets and other aquatic environments, pH is arguably the key parameter dictating chemical and biological ...
  • Continuous synthesis of Zn2Al-CO3 layered double hydroxides: a comparison of bench, pilot and industrial scale syntheses 

    Clark, Ian; Gomes, Rachel Louise; Crawshaw, C.; Neve, L.; Lodge, Rhys; Fay, Michael; Winkler, C.; Hull, Matthew S.; Lester, Ed (2019-04-01)
    Zn2Al-CO3 was produced continuously at bench (g h(-1)), pilot (100s g h -1) and industrial scale (10s kg h(-1)). Crystal domain length and BET surface area were similar at all three scales although there was a small increase ...
  • Sequence verification of synthetic DNA by assembly of sequencing reads 

    Wilson, Mandy L.; Cai, Yizhi; Hanlon, Regina; Taylor, Samantha; Chevreux, Bastien; Setubal, Joao C.; Tyler, Brett M.; Peccoud, Jean (2013-01)
    Gene synthesis attempts to assemble user-defined DNA sequences with base-level precision. Verifying the sequences of construction intermediates and the final product of a gene synthesis project is a critical part of the ...
  • XTALKDB: a database of signaling pathway crosstalk 

    Sam, Sarah A.; Teel, Joelle; Tegge, Allison N.; Bharadwaj, Aditya; Murali, T. M. (2017-01-04)
    Analysis of signaling pathways and their crosstalk is a cornerstone of systems biology. Thousands of papers have been published on these topics. Surprisingly, there is no database that carefully and explicitly documents ...
  • Effects of internal electrode cooling on irreversible electroporation using a perfused organ model 

    O’Brien, T. J.; Bonakdar, Mohammad; Bhonsle, Suyashree P.; Neal, Robert E.; Aardema, C.H.; Robertson, John L.; Goldberg, S.N.; Davalos, Rafael V. (Taylor and Francis Ltd, 2018-05-28)
    Purpose: This study evaluates the effects of active electrode cooling, via internal fluid circulation, on the irreversible electroporation (IRE) lesion, deployed electric current and temperature changes using a perfused ...
  • Processing method for grain-oriented lead-free piezoelectric Na0.5Bi0.5TiO3—BaTiO3 ceramics exhibiting giant performance 

    Mechanical Engineering; Institute for Critical Technology and Applied Science (ICTAS); Virginia Tech Intellectual Properties, Inc.; Priya, Shashank; Maurya, Deepam (United States Patent and Trademark Office, 2017-09-26)
    Textured ceramic compositions having improved piezoelectric characteristics as compared with their random counterparts are provided. Methods of making the compositions and devices using them are also included. More ...

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