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dc.contributor.authorHockey, KSen_US
dc.contributor.authorSholar, CAen_US
dc.contributor.authorSajja, VSen_US
dc.contributor.authorHubbard, WBen_US
dc.contributor.authorThorpe, Cen_US
dc.contributor.authorVandeVord, PJen_US
dc.contributor.authorRzigalinski, BAen_US
dc.date2013-04-03
dc.date.accessioned2013-09-19T19:21:06Z
dc.date.available2013-09-19T19:21:06Z
dc.date.issued2013-09-19en_US
dc.identifier.citationHockey KS, Sholar CA, Sajja VS, Hubbard WB, Thorpe C, VandeVord PJ, Rzigalinski BA, "Blasted Flies and Nanoparticles for TBI," Brain Injuries and Biomechanics Symposium, Washington DC, April 3, 2013.en_US
dc.identifier.urihttp://hdl.handle.net/10919/23817
dc.description.abstractThis presentation briefly summaries two major areas of work in our lab, development of a Drosophila model of blast injury and treatment of traumatic brain injury (TBI) with cerium oxide nanoparticles. First, we discuss the design, methodology, and results for the Drosophila blast model, and its relevance to human head injury. Briefly, we found that the Drosophila model was able to reproduce the decreased lifespan and early death seen in military personnel exposed to repetitive mild blast and NFL players exposed to repeated mild head injury. Next we discuss our in vitro and in vivo work with cerium oxide nanoparticles as neuroprotective and regenerative agents for treatment of TBI. Using a tissue culture model for TBI, we found that cerium oxide nanoparticles, delivered up to 6 hrs. post-injury, improved neuronal survival and maintained near-normal glutamate signaling in neurons of mixed organotypic brain cell cultures. In vivo, we found that delivery of cerium oxide nanoparticles prior to lateral fluid percussion brain injury in the rat, improved motor performance, learning and memory.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherBrain Injuries and Biomechanics Symposiumen_US
dc.subjecttraumatic brain injuryen_US
dc.subjectDrosophilaen_US
dc.subjectmodelsen_US
dc.subjectblasten_US
dc.subjectcerium oxide nanoparticlesen_US
dc.subjectexcitotoxicityen_US
dc.subjectneuroprotectionen_US
dc.subjectcerium oxide nanoparticlesen_US
dc.subjectnanomedicineen_US
dc.subjectnanotechnologyen_US
dc.titleBlasted Flies and Nanoparticles for TBIen_US
dc.typeArticle
dc.type.dcmitypeText


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