Collections in this community

Recent Submissions

  • Biological Sciences Newsletter, Spring/Summer 2018 

    Unknown author (Virginia Tech, 2018)
    Welcome to the Biological Sciences newsletter for spring/summer 2018! Another academic year is in the books and it has been another terrific success. In this issue we highlight one of the department’s little-known gems, ...
  • Biological Sciences Newsletter, Fall/Winter 2017 

    Unknown author (Virginia Tech, 2017)
    Welcome to the Biological Sciences newsletter for fall/winter 2017! We’ve have a great start to the academic year, with our largest entering class ever (468 freshmen and 52 transfer students) joining the undergraduate ...
  • Biological Sciences Newsletter, Fall/Winter 2018 

    Unknown author (Virginia Tech, 2018)
    This is the alumni newsletter for the Dept. of Biological Sciences at Virginia Tech.
  • Experimental manipulation of a signal trait reveals complex phenotype-behaviour coordination 

    Levin, Iris I.; Fosdick, Bailey K.; Tsunekage, Toshi; Aberle, Matthew A.; Burns, Christine M. Bergeon; Hund, Amanda K.; Safran, Rebecca J. (Springer Nature, 2018-10-19)
    Animals use morphological signals such as ornamental traits or weaponry to mediate social interactions, and the extent of signal trait elaboration is often positively associated with reproductive success. By demonstrating ...
  • Harnessing the Microbiome to Prevent Fungal Infections: Lessons from Amphibians 

    Walke, Jenifer B.; Belden, Lisa K. (PLOS, 2016-09-08)
    All multicellular organisms are host to microbial symbionts that constitute the microbiome and can have significant impacts on the host, including altering development, behavior, and health [1]. In turn, aspects of the ...
  • Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells 

    Luo, Yanting; He, Jianlin; Xu, Xiguang; Sun, Ming-an; Wu, Xiaowei; Lu, Xuemei; Xie, Hehuang (PLOS, 2018-03)
    Embryonic stem cells (ESCs) consist of a population of self-renewing cells displaying extensive phenotypic and functional heterogeneity. Research towards the understanding of the epigenetic mechanisms underlying the ...
  • Assembly of Inflammation-Related Genes for Pathway-Focused Genetic Analysis 

    Loza, Matthew J.; McCall, Charles E.; Li, Liwu; Isaacs, William B.; Xu, Jianfeng; Chang, Bao-Li (PLOS, 2007-10-17)
    Recent identifications of associations between novel variants in inflammation-related genes and several common diseases emphasize the need for systematic evaluations of these genes in disease susceptibility. Considering ...
  • Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells 

    Silkworth, William T.; Nardi, Isaac K.; Scholl, Lindsey M.; Cimini, Daniela (PLOS, 2009-08-10)
    Many cancer cells display a CIN (Chromosome Instability) phenotype, by which they exhibit high rates of chromosome loss or gain at each cell cycle. Over the years, a number of different mechanisms, including mitotic spindle ...
  • The Goldbeter-Koshland Switch in the First-Order Region and Its Response to Dynamic Disorder 

    Xing, Jianhua; Chen, Jing (PLOS, 2008-05-14)
    In their classical work (Proc. Natl. Acad. Sci. USA, 1981, 78:6840–6844), Goldbeter and Koshland mathematically analyzed a reversible covalent modification system which is highly sensitive to the concentration of effectors. ...
  • Simulations of Tubulin Sheet Polymers as Possible Structural Intermediates in Microtubule Assembly 

    Wu, Zhanghan; Wang, Hong-Wei; Mu, Weihua; Ouyang, Zhongcan; Nogales, Eva; Xing, Jianhua (PLOS, 2009-10-02)
    The microtubule assembly process has been extensively studied, but the underlying molecular mechanism remains poorly understood. The structure of an artificially generated sheet polymer that alternates two types of lateral ...
  • Sulfatides Partition Disabled-2 in Response to Platelet Activation 

    Drahos, Karen E.; Welsh, John D.; Finkielstein, Carla V.; Capelluto, Daniel G. S. (PLOS, 2009-11-24)
    Background Platelets contact each other at the site of vascular injury to stop bleeding. One negative regulator of platelet aggregation is Disabled-2 (Dab2), which is released to the extracellular surface upon platelet ...
  • Second Generation Sequencing of the Mesothelioma Tumor Genome 

    Bueno, Raphael; De Rienzo, Assunta; Dong, Lingsheng; Gordon, Gavin J.; Hercus, Colin F.; Richards, William G.; Jensen, Roderick V.; Anwar, Arif; Maulik, Gautam; Chirieac, Lucian R.; Ho, Kim-Fong; Taillon, Bruce E.; Turcotte, Cynthia L.; Hercus, Robert G.; Gullans, Steven R.; Sugarbaker, David J. (PLOS, 2010-05-13)
    The current paradigm for elucidating the molecular etiology of cancers relies on the interrogation of small numbers of genes, which limits the scope of investigation. Emerging second-generation massively parallel DNA ...
  • Shorter Exposures to Harder X-Rays Trigger Early Apoptotic Events in Xenopus laevis Embryos 

    Dong, JiaJia; Mury, Sean P.; Drahos, Karen E.; Moscovitch, Marko; Zia, Royce K. P.; Finkielstein, Carla V. (PLOS, 2010-01-29)
    Background A long-standing conventional view of radiation-induced apoptosis is that increased exposure results in augmented apoptosis in a biological system, with a threshold below which radiation doses do not cause any ...
  • Cutaneous Bacteria of the Redback Salamander Prevent Morbidity Associated with a Lethal Disease 

    Becker, Matthew H.; Harris, Reid N. (PLOS, 2010-06-04)
    Chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), is an infectious disease that causes population declines of many amphibians. Cutaneous bacteria isolated from redback salamanders, Plethodon ...
  • Mathematical Modeling for the Pathogenesis of Alzheimer's Disease 

    Puri, Ishwar K.; Li, Liwu (PLOS, 2010-12-14)
    Despite extensive research, the pathogenesis of neurodegenerative Alzheimer's disease (AD) still eludes our comprehension. This is largely due to complex and dynamic cross-talks that occur among multiple cell types throughout ...
  • Changes in Gene Expression and Cellular Architecture in an Ovarian Cancer Progression Model 

    Creekmore, Amy L.; Silkworth, William T.; Cimini, Daniela; Jensen, Roderick V.; Roberts, Paul C.; Schmelz, Eva M. (PLOS, 2011-03-03)
    Background Ovarian cancer is the fifth leading cause of cancer deaths among women. Early stage disease often remains undetected due the lack of symptoms and reliable biomarkers. The identification of early genetic changes ...
  • Drop-on-Demand Single Cell Isolation and Total RNA Analysis 

    Moon, Sangjun; Kim, Yun-Gon; Dong, Lingsheng; Lombardi, Michael; Haeggstrom, Edward; Jensen, Roderick V.; Hsiao, Li-Li; Demirci, Utkan (PLOS, 2011-03-11)
    Technologies that rapidly isolate viable single cells from heterogeneous solutions have significantly contributed to the field of medical genomics. Challenges remain both to enable efficient extraction, isolation and ...
  • Isolation and Culture of Larval Cells from C. elegans 

    Zhang, Sihui; Banerjee, Diya; Kuhn, Jeffrey R. (PLOS, 2011-04-29)
    Cell culture is an essential tool to study cell function. In C. elegans the ability to isolate and culture cells has been limited to embryonically derived cells. However, cells or blastomeres isolated from mixed stage ...
  • Testosterone, Plumage Colouration and Extra-Pair Paternity in Male North-American Barn Swallows 

    Eikenaar, Cas; Whitham, Megan; Komdeur, Jan; van der Velde, Marco; Moore, Ignacio T. (PLOS, 2011-08-10)
    In most monogamous bird species, circulating testosterone concentration in males is elevated around the social female's fertile period. Variation in elevated testosterone concentrations among males may have a considerable ...
  • Differential Annual Movement Patterns in a Migratory Species: Effects of Experience and Sexual Maturation 

    Jorge, Paulo E.; Sowter, David; Marques, Paulo A. M. (PLOS, 2011-07-20)
    Some animals migrate long distances to exploit important seasonal food resources in the northern regions of the northern hemisphere, whilst avoiding winter starvation. Changes in the individual's age and navigational skills ...

View more