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  • Modeling poliovirus replication dynamics from live time-lapse single-cell imaging data 

    Teufel, Ashley, I; Liu, Wu; Draghi, Jeremy A.; Cameron, Craig E.; Wilke, Claus O. (2021-05-05)
    Viruses experience selective pressure on the timing and order of events during infection to maximize the number of viable offspring they produce. Additionally, they may experience variability in cellular environments ...
  • Adenovirus transduction to express human ACE2 causes obesity-specific morbidity in mice, impeding studies on the effect of host nutritional status on SARS-CoV-2 pathogenesis 

    Rai, Pallavi; Chuong, Christina; LeRoith, Tanya; Smyth, James W.; Panov, Julia; Levi, Moshe; Kehn-Hall, Kylene; Duggal, Nisha K.; Lucarelli, James-Weger (Elsevier, 2021-11-01)
    The COVID-19 pandemic has paralyzed the global economy and resulted in millions of deaths globally. People with co-morbidities like obesity, diabetes and hypertension are at an increased risk for severe COVID-19 illness. ...
  • Connectivity: insights from the US Long Term Ecological Research Network 

    Iwaniec, David M.; Gooseff, Michael; Suding, Katharine N.; Samuel Johnson, David; Reed, Daniel C.; Peters, Debra P. C.; Adams, Byron; Barrett, John E.; Bestelmeyer, Brandon T.; Castorani, Max C. N.; Cook, Elizabeth M.; Davidson, Melissa J.; Groffman, Peter M.; Hanan, Niall P.; Huenneke, Laura F.; Johnson, Pieter T. J.; McKnight, Diane M.; Miller, Robert J.; Okin, Gregory S.; Preston, Daniel L.; Rassweiler, Andrew; Ray, Chris; Sala, Osvaldo E.; Schooley, Robert L.; Seastedt, Timothy; Spasojevic, Marko J.; Vivoni, Enrique R. (2021-05)
    Ecosystems across the United States are changing in complex and surprising ways. Ongoing demand for critical ecosystem services requires an understanding of the populations and communities in these ecosystems in the future. ...
  • Gradients of Anthropogenic Nutrient Enrichment Alter N Composition and DOM Stoichiometry in Freshwater Ecosystems 

    Wymore, Adam S.; Johnes, Penny J.; Bernal, Susana; Brookshire, E. N. Jack; Fazekas, Hannah M.; Helton, Ashley M.; Argerich, Alba; Barnes, Rebecca T.; Coble, Ashley A.; Dodds, Walter K.; Haq, Shahan; Johnson, Sherri L.; Jones, Jeremy B.; Kaushal, Sujay S.; Kortelainen, Pirkko; Lopez-Lloreda, Carla; Rodriguez-Cardona, Bianca M.; Spencer, Robert G. M.; Sullivan, Pamela L.; Yates, Christopher A.; McDowell, William H. (2021-08)
    A comprehensive cross-biome assessment of major nitrogen (N) species that includes dissolved organic N (DON) is central to understanding interactions between inorganic nutrients and organic matter in running waters. Here, ...
  • Diversity-production relationships of fish communities in freshwater stream ecosystems 

    Myers, Bonnie J. E.; Dolloff, C. Andrew; Webster, Jackson R.; Nislow, Keith H.; Rypel, Andrew L. (2021-09)
    Aim Ecological relationships between species richness and biomass production are increasingly thought to be pervasive across the globe. Yet, diversity-production relationships have not been explored extensively for freshwater ...
  • Runaway evolution from male-male competition 

    Moore, Allen J.; McGlothlin, Joel W.; Wolf, Jason B. (Wiley, 2021-11-16)
    Wondrously elaborate weapons and displays that appear to be counter to ecological optima are widespread features of male contests for mates across the animal kingdom. To understand how such diverse traits evolve, here we ...
  • Ecology of Nontuberculous Mycobacteria 

    Falkinham, Joseph O. (MDPI, 2021-10-30)
    Nontuberculous mycobacteria (NTM) are opportunistic human pathogens that are widespread in the human environment. In fact, NTM surround humans. The basis for their widespread presence in soils and natural and human-engineered ...
  • Aquaculture Reuse Water, Genetic Line, and Vaccination Affect Rainbow Trout (Oncorhynchus mykiss) Disease Susceptibility and Infection Dynamics 

    Everson, Jeremy L.; Jones, Darbi R.; Taylor, Amy K.; Rutan, Barb J.; Leeds, Timothy D.; Langwig, Kate E.; Wargo, Andrew R.; Wiens, Gregory D. (2021-09-22)
    Infectious hematopoietic necrosis virus (IHNV) and Flavobacterium psychrophilum are major pathogens of farmed rainbow trout. Improved control strategies are desired but the influence of on-farm environmental factors that ...
  • Effects of Rhododendron removal on soil bacterial and fungal communities in southern Appalachian forests 

    Osburn, Ernest D.; Miniat, Chelcy F.; Elliott, Katherine J.; Barrett, J. E. (2021-09-15)
    Rhododendron maximum, a native ericaceous evergreen shrub, is expanding in forests of the southern Appalachian region following eastern hemlock (Tsuga canadensis) mortality due to hemlock woolly adelgid (Adelges tsugae) ...
  • Implantable optical fibers for immunotherapeutics delivery and tumor impedance measurement 

    Chin, Ai Lin; Jiang, Shan; Jang, Eungyo; Niu, Liqian; Li, Liwu; Jia, Xiaoting; Tong, Rong (Nature Research, 2021)
    Immune checkpoint blockade antibodies have promising clinical applications but suffer from disadvantages such as severe toxicities and moderate patient–response rates. None of the current delivery strategies, including ...
  • Molecular Adaptations for Sensing and Securing Prey and Insight into Amniote Genome Diversity from the Garter Snake Genome 

    Perry, Blair W.; Card, Daren C.; McGlothlin, Joel W.; Pasquesi, Giulia IM M.; Adams, Richard H.; Schield, Drew R.; Hales, Nicole R.; Corbin, Andrew B.; Demuth, Jeffery P.; Hoffmann, Federico G.; Vandewege, Michael W.; Schott, Ryan K.; Bhattacharyya, Nihar; Chang, Belinda SW W.; Casewell, Nicholas R.; Whiteley, Gareth; Reyes-Velasco, Jacobo; Mackessy, Stephen P.; Gamble, Tony; Storey, Kenneth B.; Biggar, Kyle K.; Passow, Courtney N.; Kuo, Chih-Horng; McGaugh, Suzanne E.; Bronikowski, Anne M.; de Koning, AP Jason P. J.; Edwards, Scott V.; Pfrender, Michael E.; Minx, Patrick; Brodie, Edmund D.; Brodie, Edmund D.; Warren, Wesley C.; Castoe, Todd A. (Oxford University Press, 2018-08-01)
    Colubridae represents themost phenotypically diverse and speciose family of snakes, yet nowell-assembled and annotated genome exists for this lineage. Here, we report and analyze the genome of the garter snake, Thamnophis ...
  • Towards the characterization and engineering of bacteriophages in the gut microbiome 

    Hsu, Bryan B. (American Society for Microbiology, 2021-07-01)
    The gut microbiome and its importance to human health are a rapidly evolving area of study. Bacteria often take center stage. However, the composition is much more complex with other microbial members of the gut also playing ...
  • A cell–ECM mechanism for connecting the ipsilateral eye to the brain 

    Su, Jianmin; Sabbagh, Ubadah; Liang, Yanping; Olejníková, Lucie; Dixon, Karen G.; Russell, Ashley L.; Chen, Jiang; Pan, Yuchin Albert; Triplett, Jason W.; Fox, Michael A. (National Academy of Sciences, 2021-10-15)
    Information about features in the visual world is parsed by circuits in the retina and is then transmitted to the brain by distinct subtypes of retinal ganglion cells (RGCs). Axons from RGC subtypes are stratified in ...
  • Interference of manganese removal by biologically-mediated reductive release of manganese from MnOx(s) coated filtration media 

    Swain, Lindsay E.; Knocke, William R.; Falkinham, Joseph O.; Pruden, Amy (Elsevier, 2018-12-01)
    Discontinuing application of pre-filter chlorine is a common water treatment plant practice to permit a bioactive filtration process for the removal of soluble Mn. However, soluble Mn desorption has sometimes been observed ...
  • Field trial of a probiotic bacteria to protect bats from white-nose syndrome 

    Hoyt, Joseph R.; Langwig, Kate E.; White, J. Paul; Kaarakka, Heather M.; Redell, Jennifer A.; Parise, Katy L.; Frick, Winifred F.; Foster, Jeffrey T.; Kilpatrick, A. Marm (Nature Research, 2019-06-24)
    Tools for reducing wildlife disease impacts are needed to conserve biodiversity. White-nose syndrome (WNS), caused by the fungus Pseudogymnoascus destructans, has caused widespread declines in North American bat populations ...
  • Biophysics at the coffee shop: lessons learned working with George Oster 

    Igoshin, Oleg A.; Chen, Jing; Xing, Jianhua; Liu, Jian; Elston, Timothy C.; Grabe, Michael; Kim, Kenneth S.; Nirody, Jasmine A.; Rangamani, Padmini; Sun, Sean X.; Wang, Hongyun; Wolgemuth, Charles (American Society for Cell Biology, 2019-07-22)
    Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry. George Oster ...
  • Changes in the Fungal Community Assembly of Apple Fruit Following Postharvest Application of the Yeast Biocontrol Agent Metschnikowia fructicola 

    Biasi, Antonio; Zhimo, V. Yeka; Kumar, Ajay; Abdelfattah, Ahmed; Salim, Shoshana; Feygenberg, Oleg; Wisniewski, Michael; Droby, Samir (MDPI, 2021-10-04)
    Recently, increasing focus has been placed on exploring fruit microbiomes and their association with their hosts. Investigation of the fruit surface microbiome of apple has revealed variations in the composition and structure ...
  • Strong Purifying Selection Is Associated with Genome Streamlining in Epipelagic Marinimicrobia 

    Martinez-Gutierrez, Carolina Alejandra; Aylward, Frank O. (Oxford University Press, 2019-10-01)
    Marine microorganisms inhabiting nutrient-depleted waters play critical roles in global biogeochemical cycles due to their abundance and broad distribution. Many of these microbes share similar genomic features including ...
  • Integrating fast and slow processes is essential for simulating human-freshwater interactions 

    Ward, Nicole K.; Fitchett, Leah; Hart, Julia A.; Shu, Lele; Stachelek, Joeseph; Weng, Weizhe; Zhang, Yu; Dugan, Hilary; Hetherington, Amy; Boyle, Kevin; Carey, Cayelan C.; Cobourn, Kelly M.; Hanson, Paul C.; Kemanian, Armen R.; Sorice, Michael G.; Weathers, Kathleen C. (Springer, 2019-10-01)
    Integrated modeling is a critical tool to evaluate the behavior of coupled human–freshwater systems. However, models that do not consider both fast and slow processes may not accurately reflect the feedbacks that define ...
  • Properties of orb weaving spider glycoprotein glue change during Argiope trifasciata web construction 

    Opell, Brent D.; Stellwagen, Sarah D. (Nature Publishing Group, 2019-12-30)
    An orb web’s prey capture thread relies on its glue droplets to retain insects until a spider can subdue them. Each droplet’s viscoelastic glycoprotein adhesive core extends to dissipate the forces of prey struggle as it ...

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