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  • The adhesion function of the sodium channel beta subunit (beta 1) contributes to cardiac action potential propagation 

    Veeraraghavan, Rengasayee; Hoeker, Gregory S.; Alvarez-Laviada, Anita; Hoagland, Daniel; Wan, Xiaoping; King, D. Ryan; Sanchez-Alonso, Jose; Chen, Chunling; Jourdan, Jane; Isom, Lori L.; Deschenes, Isabelle; Smith, James W.; Gorelik, Julia; Poelzing, Steven; Gourdie, Robert G. (2018-08-14)
    Computational modeling indicates that cardiac conduction may involve ephaptic coupling - intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We ...
  • Proteomic study reveals a functional network of cancer markers in the G1-Stage of the breast cancer cell cycle 

    Tenga, Milagros J.; Lazar, Iulia M. (BMC, 2014)
    Background: Cancer cells are characterized by a deregulated cell cycle that facilitates abnormal proliferation by allowing cells to by-pass tightly regulated molecular checkpoints such as the G1/S restriction point. To ...
  • Ecology under lake ice 

    Hampton, Stephanie E.; Galloway, Aaron W. E.; Powers, Stephen M.; Ozersky, Ted; Woo, Kara H.; Batt, Ryan D.; Labou, Stephanie G.; O'Reilly, Catherine M.; Sharma, Sapna; Lottig, Noah R.; Stanley, Emily H.; North, Rebecca L.; Stockwell, Jason D.; Adrian, Rita; Weyhenmeyer, Gesa A.; Arvola, Lauri; Baulch, Helen M.; Bertani, Isabella; Bowman, Larry L., Jr.; Carey, Cayelan C.; Catalan, Jordi; Colom-Montero, William; Domine, Leah M.; Felip, Marisol; Granados, Ignacio; Gries, Corinna; Grossart, Hans-Peter; Haberman, Juta; Haldna, Marina; Hayden, Brian; Higgins, Scott N.; Jolley, Jeff C.; Kahilainen, Kimmo K.; Kaup, Enn; Kehoe, Michael J.; MacIntyre, Sally; Mackay, Anson W.; Mariash, Heather L.; Mckay, Robert M.; Nixdorf, Brigitte; Noges, Peeter; Noges, Tiina; Palmer, Michelle; Pierson, Don C.; Post, David M.; Pruett, Matthew J.; Rautio, Milla; Read, Jordan S.; Roberts, Sarah L.; Ruecker, Jacqueline; Sadro, Steven; Silow, Eugene A.; Smith, Derek E.; Sterner, Robert W.; Swann, George E. A.; Timofeyev, Maxim A.; Toro, Manuel; Twiss, Michael R.; Vogt, Richard J.; Watson, Susan B.; Whiteford, Erika J.; Xenopoulos, Marguerite A. (2017-01)
    Winter conditions are rapidly changing in temperate ecosystems, particularly for those that experience periods of snow and ice cover. Relatively little is known of winter ecology in these systems, due to a historical ...
  • Simulation Modeling of Lakes in Undergraduate and Graduate Classrooms Increases Comprehension of Climate Change Concepts and Experience with Computational Tools 

    Carey, Cayelan C.; Gougis, Rebekka Darner (2017-02)
    Ecosystem modeling is a critically important tool for environmental scientists, yet is rarely taught in undergraduate and graduate classrooms. To address this gap, we developed a teaching module that exposes students to a ...
  • Intra- and inter-annual variability in metabolism in an oligotrophic lake 

    Richardson, David C.; Carey, Cayelan C.; Bruesewitz, Denise A.; Weathers, Kathleen C. (2017-04)
    Lakes are sentinels of change in the landscapes in which they are located. Changes in lake function are reflected in whole-system metabolism, which integrates ecosystem processes across spatial and temporal scales. Recent ...
  • When an enzyme isn't just an enzyme anymore 

    Winkel, Brenda S. J. (2017-03)
    In this issue (pages 1425-1440) Bross et al. provide evidence of surprising alternative functions for two isoforms of the plastid enzyme arogenate dehydratase. This study points to a previously unsuspected connection between ...
  • Permanent Draft Genome Sequence of Desulfurococcus amylolyticus Strain Z-533(T), a Peptide and Starch Degrader Isolated from Thermal Springs in the Kamchatka Peninsula and Kunashir Island, Russia 

    Susanti, Dwi; Johnson, Eric F.; Lapidus, Alla; Han, James; Reddy, T. B. K.; Mukherjee, Supratim; Pillay, Manoj; Perevalova, Anna A.; Ivanova, Natalia N.; Woyke, Tanja; Kyrpides, Nikos C.; Mukhopadhyay, Biswarup (2017-04)
    Desulfurococcus amylolyticus Z-533(T), a hyperthermophilic crenarcheon, ferments peptide and starch, generating acetate, isobutyrate, isovalerate, CO2, and hydrogen. Unlike D. amylolyticus Z-1312, it cannot use cellulose ...
  • Complete Genome Assembly of Pantoea stewartii subsp. stewartii DC283, a Corn Pathogen 

    Duong, Duy An; Stevens, Ann M.; Jensen, Roderick V. (2017-06)
    The phytopathogen Pantoea stewartii subsp. stewartii DC283 causes Stewart's wilt disease in corn after transmission from the corn flea beetle insect vector. Here, we report that the complete annotated genome of P. stewartii ...
  • EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity 

    Sun, Zhixiong; Xu, Xiguang; He, Jianlin; Murray, Alexander; Sun, Ming-an; Wei, Xiaoran; Wang, Xia; McCoig, Emmarose; Xie, Evan; Jiang, Xi; Li, Liwu; Zhu, Jinsong; Chen, Jianjun; Morozov, Alexei; Pickrell, Alicia M.; Theus, Michelle H.; Xie, Hehuang (2019-08-29)
    Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life experience is translated into storable epigenetic information remains largely unknown. With unbiased data-driven approaches, we ...
  • A communal catalogue reveals Earth's multiscale microbial diversity 

    Thompson, Luke R.; Sanders, Jon G.; McDonald, Daniel; Amir, Amnon; Ladau, Joshua; Locey, Kenneth J.; Prill, Robert J.; Tripathi, Anupriya; Gibbons, Sean M.; Ackermann, Gail; Navas-Molina, Jose A.; Janssen, Stefan; Kopylova, Evguenia; Vazquez-Baeza, Yoshiki; Gonzalez, Antonio; Morton, James T.; Mirarab, Siavash; Xu, Zhenjiang Zech; Jiang, Lingjing; Haroon, Mohamed F.; Kanbar, Jad; Zhu, Qiyun; Song, Se Jin; Kosciolek, Tomasz; Bokulich, Nicholas A.; Lefler, Joshua; Brislawn, Colin J.; Humphrey, Gregory; Owens, Sarah M.; Hampton-Marcell, Jarrad; Berg-Lyons, Donna; McKenzie, Valerie; Fierer, Noah; Fuhrman, Jed A.; Clauset, Aaron; Stevens, Rick L.; Shade, Ashley; Pollard, Katherine S.; Goodwin, Kelly D.; Jansson, Janet K.; Gilbert, Jack A.; Knight, Rob; Rivera, Jose L. Agosto; Al-Moosawi, Lisa; Alverdy, John; Amato, Katherine R.; Andras, Jason; Angenent, Largus T.; Antonopoulos, Dionysios A.; Apprill, Amy; Armitage, David; Ballantine, Kate; Barta, Jiri; Baum, Julia K.; Berry, Allison; Bhatnagar, Ashish; Bhatnagar, Monica; Biddle, Jennifer F.; Bittner, Lucie; Boldgiv, Bazartseren; Bottos, Eric; Boyer, Donal M.; Braun, Josephine; Brazelton, William; Brearley, Francis Q.; Campbell, Alexandra H.; Caporaso, J. Gregory; Cardona, Cesar; Carroll, JoLynn; Cary, S. Craig; Casper, Brenda B.; Charles, Trevor C.; Chu, Haiyan; Claar, Danielle C.; Clark, Robert G.; Clayton, Jonathan B.; Clemente, Jose C.; Cochran, Alyssa; Coleman, Maureen L.; Collins, Gavin; Colwell, Rita R.; Contreras, Monica; Crary, Benjamin B.; Creer, Simon; Cristol, Daniel A.; Crump, Byron C.; Cui, Duoying; Daly, Sarah E.; Davalos, Liliana; Dawson, Russell D.; Defazio, Jennifer; Delsuc, Frederic; Dionisi, Hebe M.; Dominguez-Bello, Maria Gloria; Dowell, Robin; Dubinsky, Eric A.; Dunn, Peter O.; Ercolini, Danilo; Espinoza, Robert E.; Ezenwa, Vanessa; Fenner, Nathalie; Findlay, Helen S.; Fleming, Irma D.; Fogliano, Vincenzo; Forsman, Anna; Freeman, Chris; Friedman, Elliot S.; Galindo, Giancarlo; Garcia, Liza; Alexandra Garcia-Amado, Maria; Garshelis, David; Gasser, Robin B.; Gerdts, Gunnar; Gibson, Molly K.; Gifford, Isaac; Gill, Ryan T.; Giray, Tugrul; Gittel, Antje; Golyshin, Peter; Gong, Donglai; Grossart, Hans-Peter; Guyton, Kristina; Haig, Sarah-Jane; Hale, Vanessa; Hall, Ross Stephen; Hallam, Steven J.; Handley, Kim M.; Hasan, Nur A.; Haydon, Shane R.; Hickman, Jonathan E.; Hidalgo, Glida; Hofmockel, Kirsten S.; Hooker, Jeff; Hulth, Stefan; Hultman, Jenni; Hyde, Embriette; Ibanez-Alamo, Juan Diego; Jastrow, Julie D.; Jex, Aaron R.; Johnson, L. Scott; Johnston, Eric R.; Joseph, Stephen; Jurburg, Stephanie D.; Jurelevicius, Diogo; Karlsson, Anders; Karlsson, Roger; Kauppinen, Seth; Kellogg, Colleen T. E.; Kennedy, Suzanne J.; Kerkhof, Lee J.; King, Gary M.; Kling, George W.; Koehler, Anson V.; Krezalek, Monika; Kueneman, Jordan; Lamendella, Regina; Landon, Emily M.; Lane-deGraaf, Kelly; LaRoche, Julie; Larsen, Peter; Laverock, Bonnie; Lax, Simon; Lentino, Miguel; Levin, Iris I.; Liancourt, Pierre; Liang, Wenju; Linz, Alexandra M.; Lipson, David A.; Liu, Yongqin; Lladser, Manuel E.; Lozada, Mariana; Spirito, Catherine M.; MacCormack, Walter P.; MacRae-Crerar, Aurora; Magris, Magda; Martin-Platero, Antonio M.; Martin-Vivaldi, Manuel; Margarita Martinez, L.; Martinez-Bueno, Manuel; Marzinelli, Ezequiel M.; Mason, Olivia U.; Mayer, Gregory D.; McDevitt-Irwin, Jamie M.; McDonald, James E.; McGuire, Krista L.; McMahon, Katherine D.; McMinds, Ryan; Medina, Monica; Mendelson, Joseph R., III; Metcalf, Jessica L.; Meyer, Folker; Michelangeli, Fabian; Miller, Kim; Mills, David A.; Minich, Jeremiah; Mocali, Stefano; Moitinho-Silva, Lucas; Moore, Anni; Morgan-Kiss, Rachael M.; Munroe, Paul; Myrold, David; Neufeld, Josh D.; Ni, Yingying; Nicol, Graeme W.; Nielsen, Shaun; Nissimov, Jozef I.; Niu, Kefeng; Nolan, Matthew J.; Noyce, Karen; O'Brien, Sarah L.; Okamoto, Noriko; Orlando, Ludovic; Castellano, Yadira Ortiz; Osuolale, Olayinka; Oswald, Wyatt; Parnell, Jacob; Peralta-Sanchez, Juan M.; Petraitis, Peter; Pfister, Catherine; Pilon-Smits, Elizabeth; Piombino, Paola; Pointing, Stephen B.; Pollock, F. Joseph; Potter, Caitlin; Prithiviraj, Bharath; Quince, Christopher; Rani, Asha; Ranjan, Ravi; Rao, Subramanya; Rees, Andrew P.; Richardson, Miles; Riebesell, Ulf; Robinson, Carol; Rockne, Karl J.; Rodriguezl, Selena Marie; Rohwer, Forest; Roundstone, Wayne; Safran, Rebecca J.; Sangwan, Naseer; Sanz, Virginia; Schrenk, Matthew; Schrenzel, Mark D.; Scott, Nicole M.; Seger, Rita L.; Seguin-Orlando, Andaine; Seldin, Lucy; Seyler, Lauren M.; Shakhsheer, Baddr; Sheets, Gabriela M.; Shen, Congcong; Shi, Yu; Shin, Hakdong; Shogan, Benjamin D.; Shutler, Dave; Siegel, Jeffrey; Simmons, Steve; Sjoling, Sara; Smith, Daniel P.; Soler, Juan J.; Sperling, Martin; Steinberg, Peter D.; Stephens, Brent; Stevens, Melita A.; Taghavi, Safiyh; Tai, Vera; Tait, Karen; Tan, Chia L.; Tas, Neslihan; Taylor, D. Lee; Thomas, Torsten; Timling, Ina; Turner, Benjamin L.; Urich, Tim; Ursell, Luke K.; van der Lelie, Daniel; Van Treuren, William; van Zwieten, Lukas; Vargas-Robles, Daniela; Thurber, Rebecca Vega; Vitaglione, Paola; Walker, Donald A.; Walters, William A.; Wang, Shi; Wang, Tao; Weaver, Tom; Webster, Nicole S.; Wehrle, Beck; Weisenhorn, Pamela; Weiss, Sophie; Werner, Jeffrey J.; West, Kristin; Whitehead, Andrew; Whitehead, Susan R.; Whittingham, Linda A.; Willerslev, Eske; Williams, Allison E.; Wood, Stephen A.; Woodhams, Douglas C.; Yang, Yeqin; Zaneveld, Jesse; Zarraonaindia, Iratxe; Zhang, Qikun; Zhao, Hongxia (2017-11-23)
    Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized ...
  • Cell-cycle transitions: a common role for stoichiometric inhibitors 

    Hopkins, Michael; Tyson, John J.; Novak, Bela (2017-11-07)
    The cell division cycle is the process by which eukaryotic cells replicate their chromosomes and partition them to two daughter cells. To maintain the integrity of the genome, proliferating cells must be able to block ...
  • De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug 

    Lancaster, Jason; Khrimian, Ashot; Young, Sharon; Lehner, Bryan; Luck, Katrin; Wallingford, Anna; Ghosh, Saikat Kumar B.; Zerbe, Philipp; Muchlinski, Andrew; Marek, Paul E.; Sparks, Michael E.; Tokuhisa, James G.; Tittiger, Claus; Koellner, Tobias G.; Weber, Donald C.; Gundersen-Rindal, Dawn E.; Kuhar, Thomas P.; Tholl, Dorothea (2018-09-11)
    Insects use a diverse array of specialized terpene metabolites as pheromones in intraspecific interactions. In contrast to plants and microbes, which employ enzymes called terpene synthases (TPSs) to synthesize terpene ...
  • Dynamic modeling of organic carbon fates in lake ecosystems 

    McCullough, Ian M.; Dugan, Hilary A.; Farrell, Kaitlin J.; Morales-Williams, Ana M.; Ouyang, Zutao; Roberts, Derek; Scordo, Facundo; Bartlett, Sarah L.; Burke, Samantha M.; Doubek, Jonathan P.; Krivak-Tetley, Flora E.; Skaff, Nicholas K.; Summers, Jamie C.; Weathers, Kathleen C.; Hanson, Paul C. (2018-10-24)
    Lakes are active processors of organic carbon (OC) and play important roles in landscape and global carbon cycling. Allochthonous OC loads from the landscape, along with autochthonous OC loads from primary production, are ...
  • Environmental stresses induce karyotypic instability in colorectal cancer cells 

    Tan, Zhihao; Chan, Yong Jie Andrew; Chua, Ying Jie Karen; Rutledge, Samuel D.; Pavelka, Norman; Cimini, Daniela; Rancati, Giulia (2019-01)
    Understanding how cells acquire genetic mutations is a fundamental biological question with implications for many different areas of biomedical research, ranging from tumor evolution to drug resistance. While karyotypic ...
  • Suppression of Neutrophil Antimicrobial Functions by Total Particulate Matter From Cigarette Smoke 

    Zhang, Yao; Geng, Shuo; Prasad, G.L.; Li, Liwu (Frontiers, 2018-10-04)
    Chronic cigarette smoking is widely known to alter immune functions and compromise host defense against microbial infection. Neutrophils play an essential role in the immune defense against microbial pathogens and also ...
  • Innate immune programing by endotoxin and its pathological consequences 

    Morris, Matthew C.; Gilliam, Elizabeth A.; Li, Liwu (Frontiers, 2015-01-06)
    Monocytes and macrophages play pivotal roles in inflammation and homeostasis. Recent studies suggest that dynamic programing of macrophages and monocytes may give rise to distinct “memory” states. Lipopolysaccharide (LPS), ...
  • Toll-Interacting Protein in Resolving and Non-Resolving Inflammation 

    Kowalski, Elizabeth J.A.; Li, Liwu (Frontiers, 2017-05-05)
    Innate leukocytes manifest dynamic and distinct inflammatory responses upon challenges with rising dosages of pathogen-associated molecular pattern molecules such as lipopolysaccharide (LPS). To differentiate signal ...
  • Mathematical Analysis of Cytokine-Induced Differentiation of Granulocyte-Monocyte Progenitor Cells 

    Weston, Bronson R.; Li, Liwu; Tyson, John J. (Frontiers, 2018-09-18)
    Granulocyte-monocyte progenitor (GMP) cells play a vital role in the immune system by maturing into a variety of white blood cells, including neutrophils and macrophages, depending on exposure to cytokines such as various ...
  • Molecular Mechanisms That Underlie the Dynamic adaptation of innate Monocyte Memory to Varying stimulant strength of Tlr ligands 

    Yuan, Ruoxi; Geng, Shuo; Li, Liwu (Frontiers, 2016-11-10)
    In adaptation to rising stimulant strength, innate monocytes can be dynamically programed to preferentially express either pro- or anti-inflammatory mediators. Such dynamic innate adaptation or programing may bear profound ...
  • Super-low Dose Endotoxin Pre-conditioning Exacerbates Sepsis Mortality 

    Cheng, Keqiang; Geng, Shuo; Yuan, Ruoxi; Diao, Na; Upchurch, Zachary; Li, Liwu (Elsevier, 2015-03-06)
    Sepsis mortality varies dramatically in individuals of variable immune conditions, with poorly defined mechanisms. This phenomenon complements the hypothesis that innate immunity may adopt rudimentary memory, as demonstrated ...

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