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  • Mycobacterial aerosols and respiratory disease 

    Falkinham, Joseph O., III (2003-07)
    Environmental opportunistic mycobacteria, including Mycobacterium avium, M. terrae, and the new species M. immunogenum, have been implicated in outbreaks of hypersensitivity pneumonitis or respiratory problems in a wide ...
  • Nontuberculous Mycobacteria from Household Plumbing of Patients with Nontuberculous Mycobacteria Disease 

    Falkinham, Joseph O., III (2011-03)
    To determine whether plumbing could be a source of nontuberculous mycobacteria (NTM) infection, during 2007-2009 I isolated NTM from samples from household water systems of NTM patients. Samples from 22/37 (59%) households ...
  • Nontuberculous Mycobacteria in Household Plumbing as Possible Cause of Chronic Rhinosinusitis 

    Tichenor, Wellington S.; Thurlow, Jennifer; McNulty, Steven; Brown-Elliott, Barbara A.; Wallace, Richard J., Jr.; Falkinham, Joseph O., III (2012-10)
    Symptoms of chronic rhinosinusitis (CRS) often persist despite treatment. Because nontuberculous nnycobacteria (NTM) are resistant to commonly used antimicrobial drugs and are found in drinking water that patients may use ...
  • Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010-2012 

    Lande, Leah; Alexander, David C.; Wallace, Richard J., Jr.; Kwait, Rebecca; Iakhiaeva, Elena; Williams, Myra; Cameron, Andrew D. S.; Olshefsky, Stephen; Devon, Ronit; Vasireddy, Ravikiran; Peterson, Donald D.; Falkinham, Joseph O., III (2019-03)
    Attention to environmental sources of Mycobacterium avium complex (MAC) infection is a vital component of disease prevention and control. We investigated MAC colonization of household plumbing in suburban Philadelphia, ...
  • La Crosse Virus in Aedes japonicus japonicus Mosquitoes in the Appalachian Region, United States 

    Harris, M. Camille; Dotseth, Eric J.; Jackson, Bryan T.; Zink, Steven D.; Marek, Paul E.; Kramer, Laura D.; Paulson, Sally L.; Hawley, Dana M. (2015-04)
    La Crosse virus (LACV), a leading cause of arboviral encephalitis in children in the United States, is emerging in Appalachia. For local arboviral surveillance, mosquitoes were tested. LACV RNA was detected and isolated ...
  • Long-term population dynamics of dreissenid mussels (Dreissena polymorpha and D. rostriformis): a cross-system analysis 

    Strayer, David L.; Adamovich, Boris, V; Adrian, Rita; Aldridge, David C.; Balogh, Csilla; Burlakova, Lyubov E.; FriedPetersen, Hannah B.; G-Toth, Laszlo; Hetherington, Amy L.; Jones, Thomas S.; Karatayev, Alexander Y.; Madill, Jacqueline B.; Makarevich, Oleg A.; Marsden, J. Ellen; Martel, Andre L.; Minchin, Dan; Nalepa, Thomas F.; Noordhuis, Ruurd; Robinson, Timothy J.; Rudstam, Lars G.; Schwalb, Astrid N.; Smith, David R.; Steinman, Alan D.; Jeschke, Jonathan M. (Ecological Society of America, 2019-04)
    Dreissenid mussels (including the zebra mussel Dreissena polymorpha and the quagga mussel D. rostriformis) are among the world's most notorious invasive species, with large and widespread ecological and economic effects. ...
  • Enhancing collaboration between ecologists and computer scientists: lessons learned and recommendations forward 

    Carey, Cayelan C.; Ward, Nicole K.; Farrell, Kaitlin J.; Lofton, Mary E.; Krinos, Arianna, I; McClure, Ryan P.; Subratie, Kensworth C.; Figueiredo, Renato J.; Doubek, Jonathan P.; Hanson, Paul C.; Papadopoulos, Philip; Arzberger, Peter (Ecological Society of America, 2019-05)
    In the era of big data, ecologists are increasingly relying on computational approaches and tools to answer existing questions and pose new research questions. These include both software applications (e.g., simulation ...
  • Occurrence of Nontuberculous Mycobacterial Pulmonary Infection in an Endemic Area of Tuberculosis 

    Fusco da Costa, Ana Roberta; Falkinham, Joseph O., III; Lopes, Maria Luiza; Barretto, Adriana Rodrigues; Felicio, Joao Soares; Messias Sales, Lucia Helena; da Costa Bahia, Jeann Ricardo; Conceicao, Emilyn Costa; Batista Lima, Karla Valeria (PLOS, 2013-07)
    The majority of investigations of the epidemiology of nontuberculous mycobacteria (NTM) have focused on highly developed nations with a low prevalence of tuberculosis. In contrast, the Para state of north Brazil represents ...
  • Environmental Nontuberculous Mycobacteria in the Hawaiian Islands 

    Honda, Jennifer R.; Hasan, Nabeeh A.; Davidson, Rebecca M.; Williams, Myra D.; Epperson, L. Elaine; Reynolds, Paul R.; Smith, Terry; Iakhiaeva, Elena; Bankowski, Matthew J.; Wallace, Richard J., Jr.; Chan, Edward D.; Falkinham, Joseph O., III; Strong, Michael (PLOS, 2016-10)
    Lung disease caused by nontuberculous mycobacteria (NTM) is an emerging infectious disease of global significance. Epidemiologic studies have shown the Hawaiian Islands have the highest prevalence of NTM lung infections ...
  • Identification of L-Valine-initiated-germination-active genes in Bacillus subtilis using Tn-seq 

    Sayer, Cameron V.; Barat, Bidisha; Popham, David L. (PLOS, 2019-06-14)
    Bacterial endospores can survive harsh environmental conditions and long-term dormancy in the absence of nutrients, but can rapidly germinate under favorable conditions. In the present study, we employed transposon sequencing ...
  • Long-term fish assemblages of the Ohio River: Altered trophic abundances with hydrologic alterations and land use modifications 

    Pyron, Mark; Mims, Meryl C.; Minder, Mario M.; Shields, Robert C.; Chodkowski, Nicole; Artz, Caleb C. (PLOS, 2019-04-24)
    Long-term monitoring of species assemblages provides a unique opportunity to test hypotheses regarding environmentally induced directional trajectories of freshwater species assemblages. We used 57 years of lockchamber ...
  • Integrating gross morphology and bone histology to assess skeletal maturity in early dinosauromorphs: new insights from Dromomeron (Archosauria: Dinosauromorpha) 

    Griffin, Christopher T.; Bano, Lauren S.; Turner, Alan H.; Smith, Nathan D.; Irmis, Randall B.; Nesbitt, Sterling J. (PeerJ, 2019-02-11)
    Understanding growth patterns is central to properly interpreting paleobiological signals in tetrapods, but assessing skeletal maturity in some extinct Glades may be difficult when growth patterns are poorly constrained ...
  • Differential expression patterns of housekeeping genes increase diagnostic and prognostic value in lung cancer 

    Chang, Yu-Chun; Ding, Yan; Dong, Lingsheng; Zhu, Lang-Jing; Jensen, Roderick, V; Hsiao, Li-Li (PeerJ, 2018-05-09)
    Background. Using DNA microarrays, we previously identified 451 genes expressed in 19 different human tissues. Although ubiquitously expressed, the variable expression patterns of these "housekeeping genes" (HKGs) could ...
  • Linked within-host and between-host models and data for infectious diseases: a systematic review 

    Childs, Lauren M.; El Moustaid, Fadoua; Gajewski, Zachary; Kadelka, Sarah; Nikin-Beers, Ryan; Smith, John W., Jr.; Walker, Melody; Johnson, Leah R. (PeerJ, 2019-06-19)
    The observed dynamics of infectious diseases are driven by processes across multiple scales. Here we focus on two: within-host, that is, how an infection progresses inside a single individual (for instance viral and immune ...
  • Skin bacterial communities of neotropical treefrogs vary with local environmental conditions at the time of sampling 

    Estrada, Angie; Hughey, Myra C.; Medina, Daniel; Rebollar, Eria A.; Walke, Jenifer B.; Harris, Reid N.; Belden, Lisa K. (PeerJ, 2019-06-21)
    The amphibian skin microbiome has been the focus of recent studies aiming to better understand the role of these microbial symbionts in host defense against disease. However, host-associated microbial communities are complex ...
  • The Cloacal Microbiome Changes with the Breeding Season in a Wild Bird 

    Escallón, C.; Belden, L.K.; Moore, I.T. (Oxford University Press, 2018-09-29)
    The symbiotic microbial communities, or “microbiomes,” that reside on animals are dynamic, and can be affected by the behavior and physiology of the host. These communities provide many critical beneficial functions for ...
  • Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury 

    Hazy, Amanda; Bochicchio, Lauren; Oliver, Andrea; Xie, Eric; Geng, Shuo; Brickler, Thomas; Xie, Hehuang; Li, Liwu; Allen, Irving C.; Theus, Michelle H. (Springer Nature, 2019-06-12)
    The peripheral immune system is a major regulator of the pathophysiology associated with traumatic brain injury (TBI). While age-at-injury influences recovery from TBI, the differential effects on the peripheral immune ...
  • Field trial of a probiotic bacteria to protect bats from white-nose syndrome 

    Hoyt, Joseph R.; Langwig, Kate E.; White, J. Paul; Kaarakka, Heather M.; Redell, Jennifer A.; Parise, Katy L.; Frick, Winifred F.; Foster, Jeffrey T.; Kilpatrick, A. Marm (Nature Research, 2019-06-24)
    Tools for reducing wildlife disease impacts are needed to conserve biodiversity. White-nose syndrome (WNS), caused by the fungus Pseudogymnoascus destructans, has caused widespread declines in North American bat populations ...
  • Structure of the GAT domain of the endosomal adapter protein Tom1 

    Xiao, Shuyan; Ellena, Jeffrey F.; Armstrong, Geoffrey S.; Capelluto, Daniel G.S. (Elsevier, 2016-02-24)
    Cellular homeostasis requires correct delivery of cell-surface receptor proteins (cargo) to their target subcellular compartments. The adapter proteins Tom1 and Tollip are involved in sorting of ubiquitinated cargo in ...
  • Association of the circadian factor Period 2 to p53 influences p53’s function in DNA-damage signaling 

    Gotoh, Testuya; Vila-Caballer, Marian; Liu, Jingjing; Schifhauer, Samuel; Finkielstein, Carla V. (American Society for Cell Biology, 2014-11-19)
    Circadian period proteins influence cell division and death by associating with checkpoint components, although their mode of regulation has not been firmly established. hPer2 forms a trimeric complex with hp53 and its ...

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