Now showing items 1-5 of 5
Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy
(Wolters Kluwer Health, 2017-04-10)
Background Compromised lipophagy with unknown mechanisms may be critically involved in the intracellular accumulation of lipids, contributing to elevated atherosclerosis and liver steatosis. We hypothesize that ...
Molecular Mechanisms That Underlie the Dynamic adaptation of innate Monocyte Memory to Varying stimulant strength of Tlr ligands
In adaptation to rising stimulant strength, innate monocytes can be dynamically programed to preferentially express either pro- or anti-inflammatory mediators. Such dynamic innate adaptation or programing may bear profound ...
Super-low Dose Endotoxin Pre-conditioning Exacerbates Sepsis Mortality
Sepsis mortality varies dramatically in individuals of variable immune conditions, with poorly defined mechanisms. This phenomenon complements the hypothesis that innate immunity may adopt rudimentary memory, as demonstrated ...
Deficiency in Toll-interacting protein (Tollip) skews inflamed yet incompetent innate leukocytes in vivo during DSS-induced septic Colitis
Functionally compromised neutrophils contribute to adverse clinical outcomes in patients with severe inflammation and injury such as colitis and sepsis. However, the ontogeny of dysfunctional neutrophil during septic colitis ...
The persistence of low-grade inflammatory monocytes contributes to aggravated Atherosclerosis
Sustained low-grade inflammation mediated by non-resolving inflammatory monocytes has long been suspected in the pathogenesis of atherosclerosis; however, the molecular mechanisms responsible for the sustainment of ...