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Super-low Dose Endotoxin Pre-conditioning Exacerbates Sepsis Mortality
Sepsis mortality varies dramatically in individuals of variable immune conditions, with poorly defined mechanisms. This phenomenon complements the hypothesis that innate immunity may adopt rudimentary memory, as demonstrated ...
Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization
Here we show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2 macrophages. eNOS and nNOS mutant mice show comparable M1 macrophage ...