Research articles, presentations, and other scholarship

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  • Analysis of global gene expression changes in human bronchial epithelial cells exposed to spores of the allergenic fungus, Alternaria alternata 

    Babiceanu, M. C.; Howard, B. A.; Rumore, A. C.; Kita, H.; Lawrence, C. B. (Frontiers, 2013-07-19)
    Exposure and sensitivity to ubiquitous airborne fungi such as Alternaria alternata have long been implicated in the development, onset, and exacerbation of chronic allergic airway disorders. This present study is the first ...
  • Biotic interactions are an unexpected yet critical control on the complexity of an abiotically driven polar ecosystem 

    Lee, Charles K.; Laughlin, Daniel C.; Bottos, Eric M.; Caruso, Tancredi; Joy, Kurt; Barrett, John E.; Brabyn, Lars; Nielsen, Uffe N.; Adams, Byron J.; Wall, Diana H.; Hopkins, David W.; Pointing, Stephen B.; McDonald, Ian R.; Cowan, Don A.; Banks, Jonathan C.; Stichbury, Glen A.; Jones, Irfon; Zawar-Reza, Peyman; Katurji, Marwan; Hogg, Ian D.; Sparrow, Ashley D.; Storey, Bryan C.; Green, T.G. Allan; Cary, S. Craig (Springer Nature, 2019-02-15)
    Abiotic and biotic factors control ecosystem biodiversity, but their relative contributions remain unclear. The ultraoligotrophic ecosystem of the Antarctic Dry Valleys, a simple yet highly heterogeneous ecosystem, is a ...
  • Nematodes in a polar desert reveal the relative role of biotic interactions in the coexistence of soil animals 

    Caruso, Tancredi; Hogg, Ian D.; Nielsen, Uffe N.; Bottos, Eric M.; Lee, Charles K.; Hopkins, David W.; Cary, S. Craig; Barrett, John E.; Green, T.G. Allan; Storey, Bryan C.; Wall, Diana H.; Adams, Byron J. (Springer Nature, 2019-02-15)
    Abiotic factors are major determinants of soil animal distributions and their dominant role is pronounced in extreme ecosystems, with biotic interactions seemingly playing a minor role. We modelled co-occurrence and ...
  • Using "Omics" and Integrated Multi-Omics Approaches to Guide Probiotic Selection to Mitigate Chytridiomycosis and Other Emerging Infectious Diseases 

    Rebollar, Eria A.; Antwis, Rachael E.; Becker, Matthew H.; Belden, Lisa K.; Bletz, Molly C.; Brucker, Robert M.; Harrison, Xavier A.; Hughey, Myra C.; Kueneman, Jordan G.; Loudon, Andrew H.; McKenzie, Valerie; Medina, Daniel; Minbiole, Kevin P. C.; Rollins-Smith, Louise A.; Walke, Jenifer B.; Weiss, Sophie; Woodhams, Douglas C.; Harris, Ried N. (Frontiers, 2016-02-02)
    Emerging infectious diseases in wildlife are responsible for massive population declines. In amphibians, chytridiomycosis caused by Batrachochytrium dendrobatidis, Bd, has severely affected many amphibian populations and ...
  • Panamanian frog species host unique skin bacterial communities 

    Belden, Lisa K.; Hughey, Myra C.; Rebollar, Eria A.; Umile, Thomas P.; Loftus, Stephen C.; Burzynski, Elizabeth A.; Minbiole, Kevin P. C.; House, Leanna L.; Jensen, Roderick V.; Becker, Matthew H.; Walke, Jenifer B.; Medina, Daniel; Ibanez, Roberto; Harris, Reid N. (Frontiers, 2015-10-27)
    Vertebrates, including amphibians, host diverse symbiotic microbes that contribute to host disease resistance. Globally, and especially in montane tropical systems, many amphibian species are threatened by a chytrid fungus, ...
  • Microbes as Engines of Ecosystem Function: When Does Community Structure Enhance Predictions of Ecosystem Processes? 

    Graham, Emily B.; Knelman, Joseph E.; Schindlbacher, Andreas; Siciliano, Steven; Breulmann, Marc; Yannarell, Anthony; Bemans, J. M.; Abell, Guy; Philippot, Laurent; Prosser, James; Foulquier, Arnaud; Yuste, Jorge C.; Glanville, Helen C.; Jones, Davey L.; Angel, Foey; Salminen, Janne; Newton, Ryan J.; Buergmann, Helmut; Ingram, Lachlan J.; Hamer, Ute; Siljanen, Henri M. P.; Peltoniemi, Krista; Potthast, Karin; Baneras, Lluis; Hartmann, Martin; Banerjee, Samiran; Yu, Ri-Qing; Nogaro, Geraldine; Richter, Andreas; Koranda, Marianne; Castle, Sarah C.; Goberna, Marta; Song, Bongkeun; Chatterjee, Amitava; Nunes, Olga C.; Lopes, Ana R.; Cao, Yiping; Kaisermann, Aurore; Hallin, Sara; Strickland, Michael S.; Garcia-Pausas, Jordi; Barba, Josep; Kang, Hojeong; Isobe, Kazuo; Papaspyrou, Sokratis; Pastorelli, Roberta; Lagomarsino, Alessandra; Lindstrom, Eva S.; Basiliko, Nathan; Nemergut, Diana R. (Frontiers, 2016-02-24)
    Microorganisms are vital in mediating the earth's biogeochemical cycles; yet, despite our rapidly increasing ability to explore complex environmental microbial communities, the relationship between microbial community ...
  • Microbial Community Responses to Increased Water and Organic Matter in the Arid Soils of the McMurdo Dry Valleys, Antarctica 

    Buelow, Heather N.; Winter, Ara S.; Van Horn, David J.; Barrett, John E.; Gooseff, Michael N.; Schwartz, Egbert; Takacs-Vesbach, Cristina D. (Frontiers, 2016-07-18)
    The soils of the McMurdo Dry Valleys, Antarctica are an extreme polar desert, inhabited exclusively by microscopic taxa. This region is on the threshold of anticipated climate change, with glacial melt, permafrost thaw, ...
  • Culture Media and Individual Hosts Affect the Recovery of Culturable Bacterial Diversity from Amphibian Skin 

    Medina, Daniel; Walke, Jenifer B.; Gajewski, Zachary; Becker, Matthew H.; Swartwout, Meredith C.; Belden, Lisa K. (Frontiers, 2017-08-24)
    One current challenge in microbial ecology is elucidating the functional roles of the large diversity of free-living and host-associated bacteria identified by culture-independent molecular methods. Importantly, the ...
  • The Skin Microbiome of the Neotropical Frog Craugastor fitzingeri: Inferring Potential Bacterial-Host-Pathogen Interactions From Metagenomic Data 

    Rebollar, Eria A.; Gutierrez-Preciado, Ana; Noecker, Cecilia; Eng, Alexander; Hughey, Myra C.; Medina, Daniel; Walke, Jenifer B.; Borenstein, Elhanan; Jensen, Roderick V.; Belden, Lisa K.; Harris, Reid N. (Frontiers, 2018-03-20)
    Skin symbiotic bacteria on amphibians can play a role in protecting their host against pathogens. Chytridiomycosis, the disease caused by Batrachochytrium dendrobatidis, Bd, has caused dramatic population declines and ...
  • Challenges of NTM Drug Development 

    Falkinham, Joseph O., III (Frontiers, 2018-07-18)
    Discovery and development of antibiotics active against the environmental opportunistic non-tuberculous mycobacteria (NTM) have been retarded by innate antibiotic-resistance of NTM cells and methodological challenges in ...
  • Bacteria Isolated from Bats Inhibit the Growth of Pseudogymnoascus destructans, the Causative Agent of White-Nose Syndrome 

    Hoyt, Joseph R.; Cheng, Tina L.; Langwig, Kate E.; Hee, Mallory M.; Frick, Winifred F.; Kilpatrick, A. Marm (PLOS, 2015-04-08)
    Emerging infectious diseases are a key threat to wildlife. Several fungal skin pathogens have recently emerged and caused widespread mortality in several vertebrate groups, including amphibians, bats, rattlesnakes and ...
  • Limited available evidence supports theoretical predictions of reduced vaccine efficacy at higher exposure dose 

    Langwig, Kate E.; Gomes, M. Gabriela M.; Clark, Mercedes D.; Kwitny, Molly; Yamada, Steffany; Wargo, Andrew R.; Lipsitch, Marc (Nature, 2019)
    Understanding the causes of vaccine failure is important for predicting disease dynamics in vaccinated populations and planning disease interventions. Pathogen exposure dose and heterogeneity in host susceptibility have ...
  • The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation 

    Ferrezuelo, Francisco; Colomina, Neus; Palmisano, Alida; Gari, Eloi; Gallego, Carme; Csikasz-Nagy, Attila; Aldea, Marti (Springer Nature, 2012-08)
    Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size control, cell volume ...
  • Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores 

    Kajtez, Janko; Solomatina, Anastasia; Novak, Maja; Polak, Bruno; Vukusic, Kruno; Ruediger, Jonas; Cojoc, Gheorghe; Milas, Ana; Sestak, Ivana Sumanovac; Risteski, Patrik; Tavano, Federica; Klemm, Anna H.; Roscioli, Emanuele; Welburn, Julie; Cimini, Daniela; Gluncic, Matko; Pavin, Nenad; Tolic, Iva M. (Springer Nature, 2016-01)
    During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules that end at the kinetochore. Interestingly, non-kinetochore microtubules have been observed between sister kinetochores, but their ...
  • Contemporaneous radiations of fungi and plants linked to symbiosis 

    Lutzoni, Francois; Nowak, Michael D.; Alfaro, Michael E.; Reeb, Valerie; Miadlikowska, Jolanta; Krug, Michael; Arnold, A. Elizabeth; Lewis, Louise A.; Swofford, David L.; Hibbett, David; Hilu, Khidir; James, Timothy Y.; Quandt, Dietmar; Magallon, Susana (2018-12-21)
    Interactions between fungi and plants, including parasitism, mutualism, and saprotrophy, have been invoked as key to their respective macroevolutionary success. Here we evaluate the origins of plant-fungal symbioses and ...
  • A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease 

    Gilmore, Brian L.; Winton, Carly E.; Demmert, Andrew C.; Tanner, Justin R.; Bowman, Sam; Karageorge, Vasilea; Patel, Kaya; Sheng, Zhi; Kelly, Deborah F. (Springer Nature, 2015-09-23)
    We present a new molecular toolkit to investigate protein assemblies natively formed in the context of human disease. The system employs tunable microchips that can be decorated with switchable adaptor molecules to select ...
  • Identification of MOS9 as an interaction partner for chalcone synthase in the nucleus 

    Watkinson, Jonathan I.; Bowerman, Peter A.; Crosby, Kevin C.; Hildreth, Sherry B.; Helm, Richard F.; Winkel, Brenda S.J. (PeerJ, 2018-09-19)
    Plant flavonoid metabolism has served as a platform for understanding a range of fundamental biological phenomena, including providing some of the early insights into the subcellular organization of metabolism. Evidence ...
  • Calanoid copepod zooplankton density is positively associated with water residence time across the continental United States 

    Doubek, Jonathan P.; Carey, Cayelan C.; Lavender, Michael; Winegardner, Amanda K.; Beaulieu, Marieke; Kelly, Patrick T.; Pollard, Amina I.; Straile, Dietmar; Stockwell, Jason D. (PLOS, 2019-01-09)
    Inherent differences between naturally-formed lakes and human-made reservoirs may play an important role in shaping zooplankton community structure. For example, because many reservoirs are created by impounding and managing ...
  • Immunomagnetic separation of tumor initiating cells by screening two surface markers 

    Sun, Chen; Hsieh, Yuan-Pang; Ma, Sai; Geng, Shuo; Cao, Zhenning; Li, Liwu; Lu, Chang (Springer Nature, 2017-01-11)
    Isolating tumor initiating cells (TICs) often requires screening of multiple surface markers, sometimes with opposite preferences. This creates a challenge for using bead-based immunomagnetic separation (IMS) that typically ...
  • Transient ALT activation protects human primary cells from chromosome instability induced by low chronic oxidative stress 

    Coluzzi, Elisa; Buonsante, Rossella; Leone, Stefano; Asmar, Anthony J.; Miller, Kelley L.; Cimini, Daniela; Sgura, Antonella (Springer Nature, 2017-02-27)
    Cells are often subjected to the effect of reactive oxygen species (ROS) as a result of both intracellular metabolism and exposure to exogenous factors. ROS-dependent oxidative stress can induce 8-oxodG within the GGG ...

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