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  • Age-related variations in the methylome associated with gene expression in human monocytes and T cells 

    Reynolds, Lindsay M.; Taylor, Jackson R.; Ding, Jingzhong; Lohman, Kurt; Johnson, Craig; Siscovick, David; Burke, Gregory; Post, Wendy; Shea, Steven; Jacobs, David R., Jr.; Stunnenberg, Hendrik; Kritchevsky, Stephen B.; Hoeschele, Ina; McCall, Charles E.; Herrington, David M.; Tracy, Russell P.; Liu, Yongmei (Springer Nature, 2014-11)
    Age-related variations in DNA methylation have been reported; however, the functional relevance of these differentially methylated sites (age-dMS) are unclear. Here we report potentially functional age-dMS, defined as ...
  • Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis 

    Liu, Yongmei; Reynolds, Lindsay M.; Ding, Jingzhong; Hou, Li; Lohman, Kurt; Young, Tracey; Cui, Wei; Huang, Zhiqing; Grenier, Carole; Wan, Ma; Stunnenberg, Hendrik G.; Siscovick, David; Hou, Lifang; Psaty, Bruce M.; Rich, Stephen S.; Rotter, Jerome I.; Kaufman, Joel D.; Burke, Gregory L.; Murphy, Susan; Jacobs, David R., Jr.; Post, Wendy; Hoeschele, Ina; Bell, Douglas A.; Herrington, David; Parks, John S.; Tracy, Russell P.; McCall, Charles E.; Stein, James H. (Springer Nature, 2017-08-30)
    Little is known regarding the epigenetic basis of atherosclerosis. Here we present the CD14+ blood monocyte transcriptome and epigenome signatures associated with human atherosclerosis. The transcriptome signature includes ...
  • The effect of temporal aggregation level in social network monitoring 

    Zhao, Meng J.; Driscoll, Anne R.; Sengupta, Srijan; Stevens, Nathaniel T.; Fricker, Ronald D., Jr.; Woodall, William H. (PLOS, 2018-12-19)
    Social networks have become ubiquitous in modern society, which makes social network monitoring a research area of significant practical importance. Social network data consist of social interactions between pairs of ...
  • Moments, Spring 2018 

    Unknown author (Virginia Tech, 2018)
    Welcome to the inaugural edition of Moments, the Virginia Tech Department of Statistics newsletter.
  • Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma 

    Connolly, Nina P.; Shetty, Amol C.; Stokum, Jesse A.; Hoeschele, Ina; Siegel, Marni B.; Miller, C. Ryan; Kim, Anthony J.; Ho, Cheng-Ying; Davila, Eduardo; Simard, J. Marc; Devine, Scott E.; Rossmeisl, John H.; Holland, Eric C.; Winkles, Jeffrey A.; Woodworth, Graeme F. (Springer Nature, 2018-01-19)
    Glioma is a unique neoplastic disease that develops exclusively in the central nervous system (CNS) and rarely metastasizes to other tissues. This feature strongly implicates the tumor-host CNS microenvironment in gliomagenesis ...
  • Cell Cycle Model System for Advancing Cancer Biomarker Research 

    Lazar, Iulia M.; Hoeschele, Ina; de Morais, Juliana; Tenga, Milagros J. (Springer Nature, 2017-12-21)
    Progress in understanding the complexity of a devastating disease such as cancer has underscored the need for developing comprehensive panels of molecular markers for early disease detection and precision medicine applications. ...
  • Transcriptomic Analysis of Hepatic Cells in Multicellular Organotypic Liver Models 

    Tegge, Allison N.; Rodrigues, Richard R.; Larkin, Adam L.; Vu, Lucas; Murali, T. M.; Rajagopalan, Padmavathy (Springer Nature, 2018-07-27)
    Liver homeostasis requires the presence of both parenchymal and non-parenchymal cells (NPCs). However, systems biology studies of the liver have primarily focused on hepatocytes. Using an organotypic three-dimensional (3D) ...
  • Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells 

    Luo, Yanting; He, Jianlin; Xu, Xiguang; Sun, Ming-an; Wu, Xiaowei; Lu, Xuemei; Xie, Hehuang (PLOS, 2018-03)
    Embryonic stem cells (ESCs) consist of a population of self-renewing cells displaying extensive phenotypic and functional heterogeneity. Research towards the understanding of the epigenetic mechanisms underlying the ...
  • Changing measurements or changing movements? Sampling scale and movement model identifiability across generations of biologging technology 

    Johnson, Leah R.; Boersch-Supan, Philipp H.; Phillips, Richard A.; Ryan, Sadie J. (Wiley-Blackwell, 2017-10-03)
    Animal movement patterns contribute to our understanding of variation in breeding success and survival of individuals, and the implications for population dynamics. Over time, sensor technology for measuring movement ...
  • Regret Expression and Social Learning Increases Delay to Sexual Gratification 

    Quisenberry, Amanda J.; Eddy, Celia R.; Patterson, David L.; Franck, Christopher T.; Bickel, Warren K. (PLOS, 2015-08-17)
    Objective Modification and prevention of risky sexual behavior is important to individuals’ health and public health policy. This study employed a novel sexual discounting task to elucidate the effects of social learning ...
  • Community Structure and Function of Amphibian Skin Microbes: An Experiment with Bullfrogs Exposed to a Chytrid Fungus 

    Walke, Jenifer B.; Becker, Matthew H.; Loftus, Stephen C.; House, Leanna L.; Teotonio, Thais L.; Minbiole, Kevin P. C.; Belden, Lisa K. (PLOS, 2015-10-07)
    The vertebrate microbiome contributes to disease resistance, but few experiments have examined the link between microbiome community structure and disease resistance functions. Chytridiomycosis, a major cause of amphibian ...
  • Stuck in Time: Negative Income Shock Constricts the Temporal Window of Valuation Spanning the Future and the Past 

    Bickel, Warren K.; Wilson, A. George; Chen, Chen; Koffarnus, Mikhail N.; Franck, Christopher T. (PLOS, 2016-09-15)
    Insufficient resources are associated with negative consequences including decreased valuation of future reinforcers. To determine if these effects result from scarcity, we examined the consequences of acute, abrupt changes ...
  • Setting development goals using stochastic dynamical system models 

    Ranganathan, Shyam; Nicolis, Stamatios C.; Swain, Ranjula Bali; Sumpter, David J. T. (PLOS, 2017-02-27)
    The Millennium Development Goals (MDG) programme was an ambitious attempt to encourage a globalised solution to important but often-overlooked development problems. The programme led to wide-ranging development but it has ...
  • Jaccard distance based weighted sparse representation for coarse-to-fine plant species recognition 

    Zhang, Shanwen; Wu, Xiaowei; You, Zhuhong (PLOS, 2017-06-07)
    Leaf based plant species recognition plays an important role in ecological protection, however its application to large and modern leaf databases has been a long-standing obstacle due to the computational cost and feasibility. ...
  • A Statistical Framework for the Adaptive Management of Epidemiological Interventions 

    Merl, Daniel; Johnson, Leah R.; Gramacy, Robert B.; Mangel, Marc (PLOS, 2009)
    Background: Epidemiological interventions aim to control the spread of infectious disease through various mechanisms, each carrying a different associated cost. Methodology: We describe a flexible statistical framework for ...
  • Understanding uncertainty in temperature effects on vector-borne disease: a Bayesian approach 

    Johnson, Leah R.; Ben-Horin, Tal; Lafferty, Kevin D.; McNally, Amy; Mordecai, Erin; Paaijmans, Krijn P.; Pawar, Samraat; Ryan, Sadie J. (Ecological Society of America, 2015)
    Extrinsic environmental factors influence the distribution and population dynamics of many organisms, including insects that are of concern for human health and agriculture. This is particularly true for vector-borne ...
  • Mathematical models are a powerful method to understand and control the spread of Huanglongbing 

    Taylor, Rachel A.; Mordecai, Erin A.; Gilligan, Christopher A.; Rohr, Jason R.; Johnson, Leah R. (PeerJ, 2016-11-03)
    Huanglongbing (HLB), or citrus greening, is a global citrus disease occurring in almost all citrus growing regions. It causes substantial economic burdens to individual growers, citrus industries and governments. Successful ...
  • Department of Statistics Newsletter, Fall 2007 

    Unknown author (Virginia Tech, 2007)
    This is the annual newsletter of Virginia Tech’s Department of Statistics.
  • Department of Statistics Newsletter, Fall 2004 

    Unknown author (Virginia Tech, 2004)
    This is the annual newsletter of Virginia Tech’s Department of Statistics.
  • Department of Statistics Newsletter, Fall 2010 

    Unknown author (Virginia Tech, 2010)
    This is the annual newsletter of Virginia Tech’s Department of Statistics.

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