A collaboration between School of Biomedical Engineering and Sciences and the Department of Engineering Science and Mechanics to form the Department of Biomedical Engineering and Mechanics.

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  • Polo Helmet Rotational Testing 

    Rowson, Steven; Begonia, Mark T. (Virginia Tech, 2023-05-22)
    Present polo helmet testing methods only assess linear acceleration, neglecting the evaluation of a helmet's ability to reduce rotational acceleration. Both linear and rotational accelerations are key predictors of brain ...
  • Osteopathy in the Cranial Field as a Method to Enhance Brain Injury Recovery: A Preliminary Study 

    Dickerson, Michelle R.; Murphy, Susan; Hyppolite, Natalie; Brolinson, Per Gunnar; VandeVord, Pamela J. (Mary Ann Liebert, 2022-10)
    The clinical burden of traumatic brain injury (TBI) continues to grow worldwide, with patients often developing chronic neurological, behavorial, and cognitive deficits. Treatment and management strategies remain a key ...
  • Consensus Head Acceleration Measurement Practices (CHAMP): Study Design and Statistical Analysis 

    Rowson, Steven; Mihalik, Jason; Urban, Jillian; Schmidt, Julianne; Marshall, Steve; Harezlak, Jaroslaw; Stemper, Brian D.; McCrea, Mike; Funk, Jim (Springer, 2022-11)
    Head impact measurement devices enable opportunities to collect impact data directly from humans to study topics like concussion biomechanics, head impact exposure and its effects, and concussion risk reduction techniques ...
  • Atypical Neurogenesis, Astrogliosis, and Excessive Hilar Interneuron Loss Are Associated with the Development of Post-Traumatic Epilepsy 

    Gudenschwager-Basso, Erwin Kristobal; Shandra, Oleksii; Volanth, Troy; Patel, Dipan C.; Kelly, Colin; Browning, Jack L.; Wei, Xiaoran; Harris, Elizabeth A.; Mahmutovic, Dzenis; Kaloss, Alexandra M.; Correa, Fernanda Guilhaume; Decker, Jeremy; Maharathi, Biswajit; Robel, Stefanie; Sontheimer, Harald; VandeVord, Pamela J.; Olsen, Michelle L.; Theus, Michelle H. (MDPI, 2023-04-25)
    Background: Traumatic brain injury (TBI) remains a significant risk factor for post-traumatic epilepsy (PTE). The pathophysiological mechanisms underlying the injury-induced epileptogenesis are under investigation. The ...
  • Two-Fluid Large-Eddy Simulation of Two-Phase Flow in Air-Sparged Hydrocyclone 

    Bukhari, Mustafa; Fayed, Hassan; Ragab, Saad (MDPI, 2023-04-25)
    The two-fluid (Euler–Euler) model and large-eddy simulation are used to compute the turbulent two-phase flow of air and water in a cyclonic flotation device known as an Air-Sparged Hydrocyclone (ASH). In the operation ...
  • A Soluble Platelet-Derived Growth Factor Receptor-β Originates via Pre-mRNA Splicing in the Healthy Brain and Is Upregulated during Hypoxia and Aging 

    Payne, Laura Beth; Abdelazim, Hanaa; Hoque, Maruf; Barnes, Audra; Mironovova, Zuzana; Willi, Caroline E.; Darden, Jordan; Houk, Clifton; Sedovy, Meghan W.; Johnstone, Scott R.; Chappell, John C. (MDPI, 2023-04-21)
    The platelet-derived growth factor-BB (PDGF-BB) pathway provides critical regulation of cerebrovascular pericytes, orchestrating their investment and retention within the brain microcirculation. Dysregulated PDGF Receptor-beta ...
  • Clinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulation 

    Collins, Caitlyn J.; Atkins, Penny R.; Ohs, Nicholas; Blauth, Michael; Lippuner, Kurt; Mueller, Ralph (Nature Portfolio, 2022-10)
    High resolution peripheral quantitative computed tomography (HR-pQCT) provides methods for quantifying volumetric bone mineral density and microarchitecture necessary for early diagnosis of bone disease. When combined with ...
  • A proposed methodology for trip recovery training without a specialized treadmill 

    Lee, Youngjae; Alexander, Neil B.; Madigan, Michael L. (Frontiers, 2022-11)
    Falls are the leading cause of accidental injuries among adults aged 65 years and older. Perturbation-based balance training is a novel exercise-based fall prevention intervention that has shown promise in reducing falls. ...
  • Flow visualization data from experiments with an oscillating circular cylinder in a gravity-driven soap film 

    Masroor, Emad; Yang, Wenchao; Stremler, Mark A. (Elsevier, 2022-01-19)
    This article contains flow visualization data from experiments conducted in an inclined gravity-driven soap film intersected by a circular cylinder undergoing controlled transverse oscillations at a Reynolds number of Re ...
  • Robust model reference adaptive controller for atmospheric plasma spray process 

    Guduri, B.; Batra, R.C. (SN Applied Sciences, 2022-04-01)
    We add the σ-modification and the low-frequency learning to the model reference adaptive controller (MRAC) (Guduri et al. in SN Appl Sci 3:1–21, 2021) to make it robust in the presence of two simultaneous bounded disturbances ...
  • Decoding the Brain’s Surface to Track Deeper Activity 

    Tenzer, Mark L.; Lisinsk, Jonathan M.; LaConte, Stephen M. (Frontiers Media, 2022-03-17)
    Neural activity can be readily and non-invasively recorded from the scalp using electromagnetic and optical signals, but unfortunately all scalp-based techniques have depth-dependent sensitivities. We hypothesize, though, ...
  • Material properties of skin in the flying snake Chrysopelea ornata 

    Dellinger, Sarah B.; De Vita, Raffaella; Vlachos, Pavlos P.; Munoz, Martha M.; Socha, John J. (Wiley, 2023-04)
    In snakes, the skin serves for protection, camouflage, visual signaling, locomotion, and its ability to stretch facilitates large prey ingestion. The flying snakes of the genus Chrysopelea are capable of jumping and gliding ...
  • Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks 

    Walle, Matthias; Eggemann, Dominic; Atkins, Penny R.; Kendall, Jack J.; Stock, Kerstin; Muller, Ralph; Collins, Caitlyn J. (Elsevier, 2023-01)
    Image quality degradation due to subject motion confounds the precision and reproducibility of measurements of bone density, morphology and mechanical properties from high-resolution peripheral quantitative computed ...
  • Histotripsy Ablation of Spontaneously Occurring Canine Bone Tumors 

    Ruger, Lauren N.; Hay, Alayna N.; Gannon, Jessica M.; Sheppard, Hannah O.; Coutermarsh-Ott, Sheryl L.; Daniel, Gregory B.; Kierski, Katharine R.; Ciepluch, Brittany J.; Vlaisavljevich, Eli; Tuohy, Joanne L. (IEEE, 2023-01)
    Objective: Osteosarcoma (OS) is a devastating primary bone tumor in dogs and humans with limited non-surgical treatment options. As the first completely non-invasive and non-thermal ablation technique, histotripsy has the ...
  • Mitotic outcomes and errors in fibrous environments 

    Jana, Aniket; Sarkar, Apurba; Zhang, Haonan; Agashe, Atharva; Wang, Ji; Paul, Raja; Gov, Nir S.; DeLuca, Jennifer G.; Nain, Amrinder S. (National Academy of Sciences, 2023-02-27)
    During mitosis, cells round up and utilize the interphase adhesion sites within the fibrous extracellular matrix (ECM) as guidance cues to orient the mitotic spindles. Here, using suspended ECM-mimicking nanofiber networks, ...
  • Editorial: Local Hydrodynamics of Benthic Marine Organisms 

    Staples, Anne E.; Miller, Laura A.; Khatri, Shilpa; Hossain, Md Monir (Frontiers, 2023-03-28)
  • Histotripsy Ablation of Bone Tumors: Feasibility Study in Excised Canine Osteosarcoma Tumors 

    Arnold, Lauren; Hendricks-Wenger, Alissa; Coutermarsh-Ott, Sheryl; Gannon, Jessica; Hay, Alayna N.; Dervisis, Nikolaos G.; Klahn, Shawna L.; Allen, Irving C.; Tuohy, Joanne L.; Vlaisavljevich, Eli (Elsevier, 2021-12)
    Osteosarcoma (OS) is a primary bone tumor affecting both dogs and humans. Histotripsy is a non-thermal, non-invasive focused ultrasound method using controlled acoustic cavitation to mechanically disintegrate tissue. In ...
  • Reconsidering tympanal-acoustic interactions leads to an improved model of auditory acuity in a parasitoid fly 

    Staples, Anne E.; Mikel-Stites, Max; Salcedo, Mary; Marek, Paul E.; Socha, John J. (2023-03)
    Although most binaural organisms locate sound sources using neurological structures to amplify the sounds they hear, some animals use mechanically coupled hearing organs instead. One of these animals, the parasitoid fly ...
  • Mechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs with Spontaneously Occurring Soft Tissue Sarcomas 

    Ruger, Lauren; Yang, Ester; Gannon, Jessica; Sheppard, Hannah; Coutermarsh-Ott, Sheryl; Ziemlewicz, Timothy J.; Dervisis, Nikolaos G.; Allen, Irving C.; Daniel, Gregory B.; Tuohy, Joanne L.; Vlaisavljevich, Eli; Klahn, Shawna L. (IEEE, 2023-03)
    Introduction: Histotripsy is a non-invasive focused ultrasound therapy that uses controlled acoustic cavitation to mechanically disintegrate tissue. To date, there are no reports investigating histotripsy for the treatment ...
  • Isometric spiracular scaling in scarab beetles—implications for diffusive and advective oxygen transport 

    Wagner, Julian M.; Klok, C. Jaco; Duell, Meghan E.; Socha, John J.; Cao, Guohua; Gong, Hao; Harrison, Jon F. (eLife Sciences, 2022-09-01)
    The scaling of respiratory structures has been hypothesized to be a major driving factor in the evolution of many aspects of animal physiology. Here, we provide the first assessment of the scaling of the spiracles in insects ...

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