The Virginia Tech-Wake Forest University School of Biomedical Engineering & Sciences (SBES) is a joint graduate program formed in 2003 to bring together three prestigious academic institutions: the College of Engineering at Virginia Tech, the Wake Forest University School of Medicine, and the Regional Virginia-Maryland College of Veterinary Medicine. On August 11, 2014, Virginia Tech announced a new collaboration between SBES and the Engineering Science and Mechanics department to form the new Department of Biomedical Engineering and Mechanics. This department provides a strong foundation and a sturdy framework for the discovery, development, transfer, and implementation of new knowledge in the areas of mechanics of materials and material systems, fluid mechanics, dynamics and vibration, biomechanics, and computational methods. The department is fully committed to providing an environment for strong undergraduate and graduate education that emphasizes fundamental understanding rather than specialization, high-quality teaching, innovation, frontier-level research, and service to the professional mechanics community.

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Recent Submissions

  • Dynamic Analysis and Design Optimization of a Drag-Based Vibratory Swimmer 

    Tahmasian, Sevak; Jafaryzad, Arsam; Bulzoni, Nicolas L.; Staples, Anne E. (MDPI, 2020-03-22)
    Many organisms achieve locomotion via reciprocal motions. This paper presents the dynamic analysis and design optimization of a vibratory swimmer with asymmetric drag forces and fluid added mass. The swimmer consists of a ...
  • Propagating fronts in fluids with solutal feedback 

    Mukherjee, Saikat; Paul, Mark (American Physical Society, 2020-03-25)
    We numerically study the propagation of reacting fronts in a shallow and horizontal layer of fluid with solutal feedback and in the presence of a thermally driven flow field of counterrotating convection rolls. We solve ...
  • Immersion Bioprinting of Tumor Organoids in Multi-Well Plates for Increasing Chemotherapy Screening Throughput 

    Maloney, Erin; Clark, Casey; Sivakumar, Hemamylammal; Yoo, KyungMin; Aleman, Julio; Rajan, Shiny A. P.; Forsythe, Steven; Mazzocchi, Andrea; Laxton, Adrian W.; Tatter, Stephen B.; Strowd, Roy E.; Votanopoulos, Konstantinos I.; Skardal, Aleksander (MDPI, 2020-02-18)
    The current drug development pipeline takes approximately fifteen years and $2.6 billion to get a new drug to market. Typically, drugs are tested on two-dimensional (2D) cell cultures and animal models to estimate their ...
  • Pollution Transport Patterns Obtained Through Generalized Lagrangian Coherent Structures 

    Nolan, Peter J.; Foroutan, Hosein; Ross, Shane D. (MDPI, 2020-02-06)
    Identifying atmospheric transport pathways is important to understand the effects of pollutants on weather, climate, and human health. The atmospheric wind field is variable in space and time and contains complex patterns ...
  • First person - Mary Salcedo 

    Salcedo, Mary (2019-10)
    First Person is a series of interviews with the first authors of a selection of papers published in Biology Opens, helping early-career researchers promote themselves alongside their papers. Mary Salcedo is first author ...
  • 2D or 3D? How cell motility measurements are conserved across dimensions in vitro and translate in vivo 

    Galarza, Sualyneth; Kim, Hyuna; Atay, Naciye; Peyton, Shelly R.; Munson, Jennifer M. (2019-11-19)
    Cell motility is a critical aspect of several processes, such as wound healing and immunity; however, it is dysregulated in cancer. Current limitations of imaging tools make it difficult to study cell migration in vivo. ...
  • Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix) 

    Senger, Ryan S.; Kavuru, Varun; Sullivan, Meaghan; Gouldin, Austin; Lundgren, Stephanie; Merrifield, Kristen; Steen, Caitlin; Baker, Emily; Vu, Tommy; Agnor, Ben; Martinez, Gabrielle; Coogan, Hannah; Carswell, William; Karageorge, Lampros; Dev, Devasmita; Du, Pang; Sklar, Allan; Orlando, Giuseppe; Pirkle, James, Jr.; Robertson, John L. (PLOS, 2019-09-27)
    Raman chemometric urinalysis (Rametrix™) was used to analyze 235 urine specimens from healthy individuals. The purpose of this study was to establish the “range of normal” for Raman spectra of urine specimens from healthy ...
  • Treatment of Infiltrative Superficial Tumors in Awake Standing Horses Using Novel High-Frequency Pulsed Electrical Fields 

    Byron, Christopher R.; DeWitt, Matthew R.; Latouche, Eduardo L.; Davalos, Rafael V.; Robertson, John L. (Frontiers, 2019-08-14)
    Irreversible electroporation is a proven ablation modality for local ablation of soft tissue tumors in animals and humans. However, the strongmuscle contractions associated with the electrical impulses (duration, 50–100 ...
  • Velocity and geometry of propagating fronts in complex convective flow fields 

    Mukherjee, Saikat; Paul, Mark (American Physical Society, 2019-01-22)
    We numerically study the propagation of reacting fronts through three-dimensional flow fields composed of convection rolls that include time-independent cellular flow, spatiotemporally chaotic flow, and weakly turbulent ...
  • Effects of fish caudal fin sweep angle and kinematics on thrust production during low-speed thunniform swimming 

    Matta, Alexander; Bayandor, Javid; Battaglia, Francine; Pendar, Hodjat (The Company of Biologists, 2019-06-12)
    Scombrid fish lunate caudal fins are characterized by a wide range of sweep angles. Scombrid that have small sweep-angle caudal fins move at higher swimming speeds, suggesting that smaller angles produce more thrust. ...
  • Temporal Characterization of Blood–Brain Barrier Disruption with High-Frequency Electroporation 

    Lorenzo, Melvin F.; Thomas, Sean C.; Kani, Yukitaka; Hinckley, Jonathan; Lee, Matthew; Adler, Joy; Verbridge, Scott S.; Hsu, Fang-Chi; Robertson, John L.; Davalos, Rafael V.; Rossmeisl, John H. (MDPI, 2019-11-23)
    Treatment of intracranial disorders suffers from the inability to accumulate therapeutic drug concentrations due to protection from the blood–brain barrier (BBB). Electroporation-based therapies have demonstrated the ...
  • Focused ultrasound actuation of shape memory polymers; acoustic-thermoelastic modeling and testing 

    Bhargava, Aarushi; Peng, Kaiyuan; Stieg, Jerry; Mirzaeifar, Reza; Shahab, Shima (The Royal Society of Chemistry, 2017-09-18)
    Controlled drug delivery (CDD) technologies have received extensive attention recently. Despite recent efforts, drug releasing systems still face major challenges in practice, including low efficiency in releasing the ...
  • Coupling of organic and inorganic aerosol systems and the effect on gas-particle partitioning in the southeastern US 

    Pye, Havala O. T.; Zuend, Andreas; Fry, Juliane L.; Isaacman-VanWertz, Gabriel; Capps, Shannon L.; Appel, K. Wyat; Foroutan, Hosein; Xu, Lu; Ng, Nga L.; Goldstein, Allen H. (European Geophysical Union, 2018-01-12)
    Several models were used to describe the partitioning of ammonia, water, and organic compounds between the gas and particle phases for conditions in the southeastern US during summer 2013. Existing equilibrium models and ...
  • Characterization of sequentially-staged cancer cells using electrorotation 

    Trainito, Claudia I.; Sweeney, Daniel C.; Čemazăr, Jaka; Schmelz, Eva M.; Français; Le Pioufle, Bruno; Davalos, Rafael V. (PLOS, 2019-09-19)
    The identification and separation of cells from heterogeneous populations is critical to the diagnosis of diseases. Label-free methodologies in particular have been developed to manipulate individual cells using properties ...
  • Direct visualization of hemolymph flow in the heart of a grasshopper (Schistocerca americana) 

    Lee, Wah-Keat; Socha, John J. (BMC, 2009-03-09)
    Background: Hemolymph flow patterns in opaque insects have never been directly visualized due to the lack of an appropriate imaging technique. The required spatial and temporal resolutions, together with the lack of contrast ...
  • Convection-Enhanced Delivery: Connection to and Impact of Interstitial Fluid Flow 

    Stine, Caleb A.; Munson, Jennifer M. (Frontiers, 2019-10-02)
    Convection-enhanced delivery (CED) is a method used to increase transport of therapeutics in and around brain tumors. CED works through locally applying a pressure differential to drive fluid flow throughout the tumor, ...
  • Perspective on Translating Biomaterials Into Glioma Therapy: Lessons From in Vitro Models 

    Cornelison, R. Chase; Munson, Jennifer M. (Frontiers, 2018-05-09)
    Glioblastoma (GBM) is the most common and malignant form of brain cancer. Even with aggressive standard of care, GBM almost always recurs because its diffuse, infiltrative nature makes these tumors difficult to treat. The ...
  • Intercalated Disk Extracellular Nanodomain Expansion in Patients With Atrial Fibrillation 

    Raisch, Tristan B.; Yanoff, Matthew S.; Larsen, Timothy R.; Farooqui, Mohammed A.; King, D. Ryan; Veeraraghavan, Rengasayee; Gourdie, Robert G.; Baker, Joseph W.; Arnold, William S.; AlMahameed, Soufian T.; Poelzing, Steven (Frontiers, 2018-05-04)
    Aims: Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous evidence in animal models suggests that the gap junction (GJ) adjacent nanodomain - perinexus - is a site capable of independent intercellular ...
  • Otolithic Receptor Mechanisms for Vestibular-Evoked Myogenic Potentials: A Review 

    Curthoys, Ian S.; Grant, J. Wally; Burgess, Ann M.; Pastras, Chris J.; Brown, Daniel J.; Manzari, Leonardo (Frontiers, 2018-05-25)
    Air-conducted sound and bone-conduced vibration activate otolithic receptors and afferent neurons in both the utricular and saccular maculae, and trigger small electromyographic (EMG) responses [called vestibular-evoked ...
  • The adhesion function of the sodium channel beta subunit (beta 1) contributes to cardiac action potential propagation 

    Veeraraghavan, Rengasayee; Hoeker, Gregory S.; Alvarez-Laviada, Anita; Hoagland, Daniel; Wan, Xiaoping; King, D. Ryan; Sanchez-Alonso, Jose; Chen, Chunling; Jourdan, Jane; Isom, Lori L.; Deschenes, Isabelle; Smith, James W.; Gorelik, Julia; Poelzing, Steven; Gourdie, Robert G. (2018-08-14)
    Computational modeling indicates that cardiac conduction may involve ephaptic coupling - intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We ...

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