The Virginia Tech-Wake Forest University School of Biomedical Engineering & Sciences (SBES) is a joint graduate program formed in 2003 to bring together three prestigious academic institutions: the College of Engineering at Virginia Tech, the Wake Forest University School of Medicine, and the Regional Virginia-Maryland College of Veterinary Medicine. On August 11, 2014, Virginia Tech announced a new collaboration between SBES and the Engineering Science and Mechanics department to form the new Department of Biomedical Engineering and Mechanics. This department provides a strong foundation and a sturdy framework for the discovery, development, transfer, and implementation of new knowledge in the areas of mechanics of materials and material systems, fluid mechanics, dynamics and vibration, biomechanics, and computational methods. The department is fully committed to providing an environment for strong undergraduate and graduate education that emphasizes fundamental understanding rather than specialization, high-quality teaching, innovation, frontier-level research, and service to the professional mechanics community.

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Recent Submissions

  • Characterization of sequentially-staged cancer cells using electrorotation 

    Trainito, Claudia I.; Sweeney, Daniel C.; Čemazăr, Jaka; Schmelz, Eva M.; Français; Le Pioufle, Bruno; Davalos, Rafael V. (PLOS, 2019-09-19)
    The identification and separation of cells from heterogeneous populations is critical to the diagnosis of diseases. Label-free methodologies in particular have been developed to manipulate individual cells using properties ...
  • N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: Implications for breast cancer viability and proliferation in vitro 

    Ballhouse, Brittany N.; Patterson, Logan; Schmelz, Eva M.; Slade, Daniel J.; Verbridge, Scott S. (PLOS, 2017-07-10)
    It is well documented that the tumor microenvironment profoundly impacts the etiology and progression of breast cancer, yet the contribution of the resident microbiome within breast tissue remains poorly understood. Tumor ...
  • Direct visualization of hemolymph flow in the heart of a grasshopper (Schistocerca americana) 

    Lee, Wah-Keat; Socha, John J. (BMC, 2009-03-09)
    Background: Hemolymph flow patterns in opaque insects have never been directly visualized due to the lack of an appropriate imaging technique. The required spatial and temporal resolutions, together with the lack of contrast ...
  • Convection-Enhanced Delivery: Connection to and Impact of Interstitial Fluid Flow 

    Stine, Caleb A.; Munson, Jennifer M. (Frontiers, 2019-10-02)
    Convection-enhanced delivery (CED) is a method used to increase transport of therapeutics in and around brain tumors. CED works through locally applying a pressure differential to drive fluid flow throughout the tumor, ...
  • Perspective on Translating Biomaterials Into Glioma Therapy: Lessons From in Vitro Models 

    Cornelison, R. Chase; Munson, Jennifer M. (Frontiers, 2018-05-09)
    Glioblastoma (GBM) is the most common and malignant form of brain cancer. Even with aggressive standard of care, GBM almost always recurs because its diffuse, infiltrative nature makes these tumors difficult to treat. The ...
  • Intercalated Disk Extracellular Nanodomain Expansion in Patients With Atrial Fibrillation 

    Raisch, Tristan B.; Yanoff, Matthew S.; Larsen, Timothy R.; Farooqui, Mohammed A.; King, D. Ryan; Veeraraghavan, Rengasayee; Gourdie, Robert G.; Baker, Joseph W.; Arnold, William S.; AlMahameed, Soufian T.; Poelzing, Steven (Frontiers, 2018-05-04)
    Aims: Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous evidence in animal models suggests that the gap junction (GJ) adjacent nanodomain - perinexus - is a site capable of independent intercellular ...
  • Otolithic Receptor Mechanisms for Vestibular-Evoked Myogenic Potentials: A Review 

    Curthoys, Ian S.; Grant, J. Wally; Burgess, Ann M.; Pastras, Chris J.; Brown, Daniel J.; Manzari, Leonardo (Frontiers, 2018-05-25)
    Air-conducted sound and bone-conduced vibration activate otolithic receptors and afferent neurons in both the utricular and saccular maculae, and trigger small electromyographic (EMG) responses [called vestibular-evoked ...
  • The adhesion function of the sodium channel beta subunit (beta 1) contributes to cardiac action potential propagation 

    Veeraraghavan, Rengasayee; Hoeker, Gregory S.; Alvarez-Laviada, Anita; Hoagland, Daniel; Wan, Xiaoping; King, D. Ryan; Sanchez-Alonso, Jose; Chen, Chunling; Jourdan, Jane; Isom, Lori L.; Deschenes, Isabelle; Smith, James W.; Gorelik, Julia; Poelzing, Steven; Gourdie, Robert G. (2018-08-14)
    Computational modeling indicates that cardiac conduction may involve ephaptic coupling - intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We ...
  • Characterization of Conventional One-Step Sodium Thiosulfate Facilitated Gold Nanoparticle Synthesis 

    Saverot, Scott-Eugene; Reese, Laura M.; Cimini, Daniela; Vikesland, Peter J.; Bickford, Lisette Ramirez (SpringerOpen, 2015-05-28)
    Gold-gold sulfide nanoparticles are of interest for drug delivery, biomedical imaging, and photothermal therapy applications due to a facile synthesis method resulting in small particles with high near-infrared (NIR) ...
  • High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity 

    Ringel-Scaia, Veronica M.; Beitel-White, Natalie; Lorenzo, Melvin F.; Brock, Rebecca M.; Huie, Kathleen E.; Coutermarsh-Ott, Sheryl; Eden, Kristin; McDaniel, Dylan K.; Verbridge, Scott S.; Rossmeisl, John H., Jr.; Oestreich, Kenneth J.; Davalos, Rafael, V; Allen, Irving C. (2019-06)
    Background: Despite promising treatments for breast cancer, mortality rates remain high and treatments for metastatic disease are limited. High-frequency irreversible electroporation (H-FIRE) is a novel tumor ablation ...
  • Blood Vessel Patterning on Retinal Astrocytes Requires Endothelial Flt-1 (VEGFR-1) 

    Chappell, John C.; Darden, Jordan; Payne, Laura Beth; Fink, Kathryn; Bautch, Victoria L. (MDPI, 2019-09-07)
    Feedback mechanisms are critical components of many pro-angiogenic signaling pathways that keep vessel growth within a functional range. The Vascular Endothelial Growth Factor-A (VEGF-A) pathway utilizes the decoy VEGF-A ...
  • Ranges of Injury Risk Associated with Impact from Unmanned Aircraft Systems 

    Campolettano, Eamon T.; Bland, Megan L.; Gellner, Ryan A.; Sproule, David W.; Rowson, Bethany; Tyson, Abigail M.; Duma, Stefan M.; Rowson, Steven (2017-12)
    Regulations have allowed for increased unmanned aircraft systems (UAS) operations over the last decade, yet operations over people are still not permitted. The objective of this study was to estimate the range of injury ...
  • Infographic: ACL injury reconstruction and recovery 

    Queen, R.M. (British Editorial Society of Bone and Joint Surgery, 2017)
    Anterior cruciate ligament (ACL) injury is a considerable source of morbidity among athletes. Most ACL injuries (70%) are non-contact in nature, with women and patients aged between 15 and 30 years at particularly high ...
  • Development of the STAR Evaluation System for Assessing Bicycle Helmet Protective Performance 

    Bland, Megan L.; McNally, Craig; Zuby, David S.; Mueller, Becky C.; Rowson, Steven (Biomedical Engineering Society, 2019-08-01)
    Cycling is a leading cause of mild traumatic brain injury in the US. While bicycle helmets help protect cyclists who crash, limited biomechanical data exist differentiating helmet protective capabilities. This paper describes ...
  • Do Infield Softball Masks Effectively Reduce Facial Fracture Risk? 

    Morris, Tyler P.; Gellner, Ryan A.; Rowson, Steven (2019-02)
    Infield softball masks are intended to reduce facial fracture risk, but are rarely worn. The objective of this study was to evaluate the effectiveness of infield masks' ability to attenuate facial fracture risk over a range ...
  • Electropermeabilization of nematode eggs for parasite deactivation 

    Dryzer, M. H.; Niven, C.; Wolter, S. D.; Arena, C. B.; Ngaboyamahina, E.; Parker, C. B.; Stoner, B. R. (2019-03)
    The eggs of parasitic helminth worms are incredibly resilient - possessing the ability to survive changing environmental factors and exposure to chemical treatments - which has restricted the efficacy of wastewater sanitation. ...
  • Electrophysiologic effects of the I-K1 inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts 

    Hoeker, Gregory S.; Skarsfeldt, Mark A.; Jespersen, Thomas; Poelzing, Steven (The Physiological Society, 2017-01)
    The pentamidine analog PA-6 was developed as a specific inward rectifier potassium current (I-K1) antagonist, because established inhibitors either lack specificity or have side effects that prohibit their use in vivo. We ...
  • Repetitive Head Impact Exposure in College Football Following an NCAA Rule Change to Eliminate Two-A-Day Preseason Practices: A Study from the NCAA-DoD CARE Consortium 

    Stemper, Brian D.; Shah, Alok S.; Harezlak, Jaroslaw; Rowson, Steven; Duma, Stefan M.; Mihalik, Jason P.; Riggen, Larry D.; Brooks, Alison; Cameron, Kenneth L.; Giza, Christopher C.; Houston, Megan N.; Jackson, Jonathan; Posner, Matthew A.; McGinty, Gerald; DiFiori, John; Broglio, Steven P.; McAllister, Thomas W.; McCrea, Michael (Biomedical Engineering Society, 2019-08-06)
    Repetitive head impact exposure sustained by athletes of contact sports has been hypothesized to be a mechanism for concussion and a possible explanation for the high degree of variability in sport-related concussion ...
  • Self-Stabilizing Transpiration in Synthetic Leaves 

    Shi, Weiwei; Vieitez, Joshua R.; Berrier, Austin S.; Roseveare, Matthew W.; Surinach, Daniel A.; Srijanto, Bernadeta R.; Collier, C. Patrick; Boreyko, Jonathan B. (2019-04-10)
    Over the past decade, synthetic trees have been engineered to mimic the transpiration cycle of natural plants, but the leaves are prone to dry out beneath a critical relative humidity. Here, we create large-area synthetic ...
  • How soap bubbles freeze 

    Ahmadi, S. Farzad; Nath, Saurabh; Kingett, Christian M.; Yue, Pengtao; Boreyko, Jonathan B. (Springer Nature, 2019-06-18)
    Droplets or puddles tend to freeze from the propagation of a single freeze front. In contrast, videographers have shown that as soap bubbles freeze, a plethora of growing ice crystals can swirl around in a beautiful effect ...

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