Browsing Scholarly Works, Department of Biochemistry by Issue Date
Now showing items 1-20 of 237
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Editorial: ‘To err is human, it takes a computer to really foul things up!’*
(Hindawi, 1985-01-01) -
Effects of anti-inflammatory drugs on fever and neutrophilia induced by Clostridium difficile toxin B
(Hindawi Publishing Corporation, 1996-06)This study investigated the ability of Clostridium difficile toxin B, isolated from the VPI 10463 strain, to induce fever and neutrophilia in rats. Intravenous injection of toxin B (0.005-0.5 mu g/kg) evoked a dose-dependent ... -
Molecular dynamics simulations of the d(CCAACGTTGG)(2) decamer: Influence of the crystal environment
(CELL PRESS, 2000-02)Molecular dynamics (MD) simulations of the DNA duplex d(CCAACGTTGG)(2) were used to study the relationship between DNA sequence and structure. Two crystal simulations were carried out; one consisted of one unit cell ... -
Label-free DNA sequence detection using oligonucleotide functionalized optical fiber
(AIP Publishing, 2006-10-01)The authors present a label-free method for direct detection of deoxyribonucleic acid (DNA) sequences. The capture DNA is immobilized onto the surface of a silica optical fiber tip by means of the layer-by-layer electrostatic ... -
The Juan non-LTR retrotransposon in mosquitoes: genomic impact, vertical transmission and indications of recent and wide-spread activity
(2007-07-09)Background In contrast to DNA-mediated transposable elements (TEs), retrotransposons, particularly non-long terminal repeat retrotransposons (non-LTRs), are generally considered to have a much lower propensity towards ... -
CMGSDB: integrating heterogeneous Caenorhabditis elegans data sources using compositional data mining
(Oxford Univ Press, 2008-01-01)CMGSDB (Database for Computational Modeling of Gene Silencing) is an integration of heterogeneous data sources about Caenorhabditis elegans with capabilities for compositional data mining (CDM) across diverse domains. ... -
Cloning, characterization, and expression of microRNAs from the Asian malaria mosquito, Anopheles stephensi
(2008-05-23)Background microRNAs (miRNAs) are non-coding RNAs that are now recognized as a major class of gene-regulating molecules widely distributed in metozoans and plants. miRNAs have been found to play important roles in apoptosis, ... -
Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit
(Academic Press Ltd Elsevier Science Ltd, 2008-05-29)Human C8 is one of five complement components (C5b, C6, C7, C8 and C9) that assemble on bacterial membranes to form a pore-like structure referred to as the "membrane attack complex" (MAC). C8 contains three genetically ... -
Insertion polymorphisms of SINE200 retrotransposons within speciation islands of Anopheles gambiae molecular forms
(Biomed Central Ltd, 2008-08-25)Background SINEs (Short INterspersed Elements) are homoplasy-free and co-dominant genetic markers which are considered to represent useful tools for population genetic studies, and could help clarifying the speciation ... -
RNA Interference of Trypanosoma brucei Cathepsin B and L Affects Disease Progression in a Mouse Model
(PLOS, 2008-09-01)We investigated the roles played by the cysteine proteases cathepsin B and cathepsin L (brucipain) in the pathogenesis of Trypansoma brucei brucei in both an in vivo mouse model and an in vitro model of the blood–brain ... -
Odorant receptor c-terminal motifs in divergent insect species
(Entomological Society of America, 2008-09-22)Insect odorant receptors are a large family of seven transmembrane proteins believed to be G-protein coupled receptors. The peptide sequences of two odorant receptors within a given species may share as little as 17% ... -
Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit
(PLOS, 2009-02-01)Background: The two front-line drugs for chronic Trypanosoma cruzi infections are limited by adverse side-effects and declining efficacy. One potential new target for Chagas’ disease chemotherapy is sterol 14a-demethylase ... -
The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota
(2009-04-02)Background Staphylothermus marinus is an anaerobic, sulfur-reducing peptide fermenter of the archaeal phylum Crenarchaeota. It is the third heterotrophic, obligate sulfur reducing crenarchaeote to be sequenced and provides ... -
Direct sequencing and expression analysis of a large number of miRNAs in Aedes aegypti and a multi-species survey of novel mosquito miRNAs
(2009-12-04)Background MicroRNAs (miRNAs) are a novel class of gene regulators whose biogenesis involves hairpin structures called precursor miRNAs, or pre-miRNAs. A pre-miRNA is processed to make a miRNA:miRNA* duplex, which is then ... -
BpaB, a novel protein encoded by the Lyme disease spirochete’s cp32 prophages, binds to erp Operator 2 DNA
(Oxford University Press, 2010)Borrelia burgdorferi produces Erp outer surface proteins throughout mammalian infection, but represses their synthesis during colonization of vector ticks. A DNA region 50 of the start of erp transcription, Operator 2, was ... -
Virtual Screening as a Technique for PPAR Modulator Discovery
(Hindawi Publishing Corporation, 2010-01-01)Virtual screening (VS) is a discovery technique to identify novel compounds with therapeutic and preventive efficacy against disease. Our current focus is on the in silico screening and discovery of novel peroxisome ... -
Characterization of ESBL (SHV-12) producing clinical isolate of Enterobacter aerogenes from a tertiary care hospital in Nigeria
(2010-01-12)Background We studied the beta-lactamases of an E. aerogenes isolate recovered from the blood of a two-year-old patient. The isolate demonstrated a disk-diffusion phenotype typical for an AmpC-ESBL co-producer. Methods M ... -
Crystal Structure and Substrate Specificity of Drosophila 3,4-Dihydroxyphenylalanine Decarboxylase
(PLOS, 2010-01-21)Background 3,4-Dihydroxyphenylalanine decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, catalyzes the decarboxylation of a number of aromatic L-amino acids. Physiologically, DDC is responsible for ... -
The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide
(Biomed Central Ltd, 2010-01-22)Background A plant-based diet protects against chronic oxidative stress-related diseases. Dietary plants contain variable chemical families and amounts of antioxidants. It has been hypothesized that plant antioxidants may ... -
Genome Landscape and Evolutionary Plasticity of Chromosomes in Malaria Mosquitoes
(PLOS, 2010-05-12)Background: Nonrandom distribution of rearrangements is a common feature of eukaryotic chromosomes that is not well understood in terms of genome organization and evolution. In the major African malaria vector Anopheles ...
