Browsing Faculty Works, Department of Biochemistry by Issue Date
Now showing items 1-20 of 124
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Effects of anti-inflammatory drugs on fever and neutrophilia induced by Clostridium difficile toxin B
(Hindawi Publishing Corporation, 1996-06)This study investigated the ability of Clostridium difficile toxin B, isolated from the VPI 10463 strain, to induce fever and neutrophilia in rats. Intravenous injection of toxin B (0.005-0.5 mu g/kg) evoked a dose-dependent ... -
Molecular dynamics simulations of the d(CCAACGTTGG)(2) decamer: Influence of the crystal environment
(CELL PRESS, 2000-02)Molecular dynamics (MD) simulations of the DNA duplex d(CCAACGTTGG)(2) were used to study the relationship between DNA sequence and structure. Two crystal simulations were carried out; one consisted of one unit cell ... -
Label-free DNA sequence detection using oligonucleotide functionalized optical fiber
(AIP Publishing, 2006-10-01)The authors present a label-free method for direct detection of deoxyribonucleic acid (DNA) sequences. The capture DNA is immobilized onto the surface of a silica optical fiber tip by means of the layer-by-layer electrostatic ... -
The Juan non-LTR retrotransposon in mosquitoes: genomic impact, vertical transmission and indications of recent and wide-spread activity
(2007-07-09)Background In contrast to DNA-mediated transposable elements (TEs), retrotransposons, particularly non-long terminal repeat retrotransposons (non-LTRs), are generally considered to have a much lower propensity towards ... -
CMGSDB: integrating heterogeneous Caenorhabditis elegans data sources using compositional data mining
(Oxford Univ Press, 2008-01-01) -
Cloning, characterization, and expression of microRNAs from the Asian malaria mosquito, Anopheles stephensi
(2008-05-23)Background microRNAs (miRNAs) are non-coding RNAs that are now recognized as a major class of gene-regulating molecules widely distributed in metozoans and plants. miRNAs have been found to play important roles in apoptosis, ... -
Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit
(Academic Press Ltd Elsevier Science Ltd, 2008-05-29) -
Insertion polymorphisms of SINE200 retrotransposons within speciation islands of Anopheles gambiae molecular forms
(Biomed Central Ltd, 2008-08-25)Background SINEs (Short INterspersed Elements) are homoplasy-free and co-dominant genetic markers which are considered to represent useful tools for population genetic studies, and could help clarifying the speciation ... -
The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota
(2009-04-02)Background Staphylothermus marinus is an anaerobic, sulfur-reducing peptide fermenter of the archaeal phylum Crenarchaeota. It is the third heterotrophic, obligate sulfur reducing crenarchaeote to be sequenced and provides ... -
Direct sequencing and expression analysis of a large number of miRNAs in Aedes aegypti and a multi-species survey of novel mosquito miRNAs
(2009-12-04)Background MicroRNAs (miRNAs) are a novel class of gene regulators whose biogenesis involves hairpin structures called precursor miRNAs, or pre-miRNAs. A pre-miRNA is processed to make a miRNA:miRNA* duplex, which is then ... -
BpaB, a novel protein encoded by the Lyme disease spirochete’s cp32 prophages, binds to erp Operator 2 DNA
(Oxford University Press, 2010)Borrelia burgdorferi produces Erp outer surface proteins throughout mammalian infection, but represses their synthesis during colonization of vector ticks. A DNA region 50 of the start of erp transcription, Operator 2, was ... -
Virtual Screening as a Technique for PPAR Modulator Discovery
(Hindawi Publishing Corporation, 2010-01-01)Virtual screening (VS) is a discovery technique to identify novel compounds with therapeutic and preventive efficacy against disease. Our current focus is on the in silico screening and discovery of novel peroxisome ... -
Crystal Structure and Substrate Specificity of Drosophila 3,4-Dihydroxyphenylalanine Decarboxylase
(PLOS, 2010-01-21)Background 3,4-Dihydroxyphenylalanine decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, catalyzes the decarboxylation of a number of aromatic L-amino acids. Physiologically, DDC is responsible for ... -
The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide
(Biomed Central Ltd, 2010-01-22)Background A plant-based diet protects against chronic oxidative stress-related diseases. Dietary plants contain variable chemical families and amounts of antioxidants. It has been hypothesized that plant antioxidants may ... -
Genome Landscape and Evolutionary Plasticity of Chromosomes in Malaria Mosquitoes
(PLOS, 2010-05-12) -
Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases
(2010-05-19)Background Kynurenine aminotransferase (KAT) catalyzes the transamination of kynunrenine to kynurenic acid (KYNA). KYNA is a neuroactive compound and functions as an antagonist of alpha7-nicotinic acetylcholine receptors ... -
Evolutionary analysis of the kinesin light chain genes in the yellow fever mosquito Aedes aegypti: gene duplication as a source for novel early zygotic genes
(2010-07-08)Background The maternal zygotic transition marks the time at which transcription from the zygotic genome is initiated and a subset of maternal RNAs are progressively degraded in the developing embryo. A number of early ...
