Browsing Scholarly Works, Department of Biomedical Sciences and Pathobiology by Title

A 6-Nucleotide Regulatory Motif within the AbcR Small RNAs of Brucella abortus Mediates Host-Pathogen Interactions

Sheehan, Lauren M.; Caswell, Clayton C. (American Society for Microbiology, 2017-05)

In Brucella abortus, two small RNAs (sRNAs), AbcR1 and AbcR2, are responsible for regulating transcripts encoding ABC-type transport systems. AbcR1 and AbcR2 are required for Brucella virulence, as a double chromosomal ...

A Review: competence, compromise, and concomitance-reaction of the host cell to toxoplasma gondii infection and development

Peng, H. J.; Chen, X. G.; Lindsay, D. S. (American Society of Parasitology, 2011-08)

Toxoplasma gondii is an important zoonotic parasite with a worldwide distribution. It infects about one-third of the world's population, causing serious illness in immunosuppressed individuals, fetuses, and infants. ...

The activation of the IFN beta induction/signaling pathway in porcine alveolar macrophages by porcine reproductive and respiratory syndrome virus is variable

Overend, Christopher C.; Cui, Junru; Grubman, Marvin J.; Garmendia, Antonio E. (2017-03)

Background It has been recognized that the expression of type I interferon (IFN alpha/beta) may be suppressed during infection with porcine reproductive, respiratory syndrome virus (PRRSV). This causes profound negative ...

Adrenocortical Challenge Response and Genomic Analyses in Scottish Terriers With Increased Alkaline Phosphate Activity

Zimmerman, Kurt L.; Panciera, David L.; Hoeschele, Ina; Monroe, William Edward; Todd, Stephanie Michelle; Werre, Stephen R.; LeRoith, Tanya; Fecteau, Kellie; Lake, Bathilda B. (Frontiers, 2018-10-09)

Scottish terriers (ST) frequently have increased serum alkaline phosphatase (ALP) of the steroid isoform. Many of these also have high serum concentrations of adrenal sex steroids. The study’s objective was to determine ...

Adventitious viruses persistently infect three commonly used mosquito cell lines

Weger-Lucarelli, James; Ruckert, Claudia; Grubaugh, Nathan D.; Misencik, Michael J.; Armstrong, Philip M.; Stenglein, Mark D.; Ebel, Gregory D.; Brackney, Doug E. (2018-08)

Mosquito cell lines have been used extensively in research to isolate and propagate arthropod-borne viruses and understand virus-vector interactions. Despite their utility as an in vitro tool, these cell lines are poorly ...

Ambient and Dosed Exposure to Quaternary Ammonium Disinfectants Causes Neural Tube Defects in Rodents

Hrubec, Terry C.; Melin, Vanessa E.; Shea, Caroline S.; Ferguson, Elizabeth E.; Garofola, Craig; Repine, Claire M.; Chapman, Tyler W.; Patel, Hiral R.; Razvi, Reza M.; Sugrue, Jesse E.; Potineni, Haritha; Magnin-Bissel, Geraldine; Hunt, Patricia A. (2017-08-15)

Background: Quaternary ammonium compounds are a large class of chemicals used for their antimicrobial and antistatic properties. Two common quaternary ammonium compounds, alkyldimethylbenzyl ammonium chloride (ADBAC) and ...

Analysis of the Murine Immune Response to Pulmonary Delivery of Precisely Fabricated Nano- and Microscale Particles

Roberts, Reid A.; Shen, Tammy; Allen, Irving C.; Hasan, Warefta; DeSimone, Joseph M.; Ting, Jenny P. Y. (PLOS, 2013-04-12)

Nanomedicine has the potential to transform clinical care in the 21st century. However, a precise understanding of how nanomaterial design parameters such as size, shape and composition affect the mammalian immune system ...

Ancient, globally distributed lineage of Sarcocystis from sporocysts of the Eastern rat snake (Pantherophis alleghaniensis) and its relation to neurological sequalae in intermediate hosts

Verma, Shiv K.; Lindsay, David S.; Rosenthal, Benjamin M.; Dubey, Jitender P. (2016-07)

There is an emerging concern that snakes are definitive hosts of certain species of Sarcocystis that cause muscular sarcocystosis in human and non-human primates. Other species of Sarcocystis are known to cycle among snakes ...

Antibiofilm Activity of Actinobacillus pleuropneumoniae Serotype 5 Capsular Polysaccharide

Karwacki, Michael T.; Kadouri, Daniel E.; Bendaoud, Meriem; Izano, Era A.; Sampathkumar, Vandana; Inzana, Thomas J.; Kaplan, Jeffrey B. (PLOS, 2013-05-14)

Cell-free extracts isolated from colony biofilms of Actinobacillus pleuropneumoniae serotype 5 were found to inhibit biofilm formation by Staphylococcus aureus, S. epidermidis and Aggregatibacter actinomycetemcomitans, but ...

Antibiotics ameliorate lupus-like symptoms in mice

Mu, Qinghui; Tavella, Vincent J.; Kirby, Jay L.; Cecere, Thomas E.; Chung, Matthias; Lee, Jiyoung; Li, Song; Ahmed, S. Ansar; Eden, Kristin; Allen, Irving C. (Nature, 2017-10-20)

Gut microbiota and the immune system interact to maintain tissue homeostasis, but whether this interaction is involved in the pathogenesis of systemic lupus erythematosus (SLE) is unclear. Here we report that oral antibiotics ...

The Application of a Nanomaterial Optical Fiber Biosensor Assay for Identification of Brucella Nomenspecies

McCutcheon, Kelly; Bandara, Aloka B.; Zuo, Ziwei; Heflin, James R.; Inzana, Thomas J. (MDPI, 2019-05-21)

Bacteria in the genus Brucella are the cause of brucellosis in humans and many domestic and wild animals. A rapid and culture-free detection assay to detect Brucella in clinical samples would be highly valuable. ...

Besnoitia oryctofelisi n. sp (Protozoa : Apicomplexa) from domestic rabbits

Dubey, J. P.; Sreekumar, C.; Lindsay, D. S.; Hill, D.; Rosenthal, B. M.; Venturini, L.; Venturini, M. C.; Greiner, E. C. (Cambridge University Press, 2003-06)

A species of Besnoitia from naturally infected rabbits from Argentina was propagated experimentally in mice, gerbils, rabbits, cats, and cell cultures. Cats fed tissue cysts from rabbits shed oocysts with a prepatent period ...

Bovine fetal mesenchymal stem cells exert antiproliferative effect against mastitis causing pathogen Staphylococcus aureus

Cahuascanco, Berly; Bahamonde, Javiera; Huaman, Olger; Jervis, Miguel; Cortez, Jahaira; Palomino, Jaime; Escobar, Alejandro; Retamal, Patricio; Torres, Cristian G; Peralta, Oscar A (2019-04-11)

Abstract Staphylococcus aureus is the most commonly isolated pathogen from clinical bovine mastitis samples and a difficult pathogen to combat. Mesenchymal stem cells (MSC) are multipotent progenitor cells ...

Broadening the Heterologous Cross-Neutralizing Antibody Inducing Ability of Porcine Reproductive and Respiratory Syndrome Virus by Breeding the GP4 or M genes

Zhou, Lei; Ni, Yan-Yan; Pineyro, Pablo; Cossaboom, Caitlin M.; Subramaniam, Sakthivel; Sanford, Brenton J.; Dryman, Barbara A.; Huang, Yao-Wei; Meng, Xiang-Jin (PLOS, 2013-06-24)

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important swine pathogens, which causes reproductive failure in sows and respiratory disease in piglets. A major hurdle to control ...

Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains

Suarez-Esquivel, Marcela; Ruiz-Villalobos, Nazareth; Castillo-Zeledon, Amanda; Jimenez-Rojas, Cesar; Roop, R. Martin, II; Comerci, Diego J.; Barquero-Calvo, Elias; Chacon-Diaz, Carlos; Caswell, Clayton C.; Baker, Kate S.; Chaves-Olarte, Esteban; Thomson, Nicholas R.; Moreno, Edgardo; Letesson, Jean J.; De Bolle, Xavier; Guzman-Verri, Caterina (Frontiers, 2016-09-29)

Brucellosis is a bacterial infectious disease affecting a wide range of mammals and a neglected zoonosis caused by species of the genetically homogenous genus Brucella. As in most studies on bacterial diseases, research ...

Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

Ojo, Kayode K.; Ranade, Ranae M.; Zhang, Zhongsheng; Dranow, David M.; Myers, Janette B.; Choi, Ryan; Hewitt, Steve Nakazawa; Edwards, Thomas E.; Davies, Douglas R.; Lorimer, Donald; Boyle, Stephen M.; Barrett, Lynn K.; Buckner, Frederick S.; Fan, Erkang; Van Voorhis, Wesley C. (PLOS, 2016-08-08)

We investigated Brucella melitensis methionyl-tRNA-synthetase (BmMetRS) with molecular, structural and phenotypic methods to learn if BmMetRS is a promising target for brucellosis drug development. Recombinant BmMetRS was ...