Scholarly Works, Institute for Critical Technology and Applied Science (ICTAS)
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Research articles, presentations, and other scholarship
Recent Submissions
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Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review
(IEEE, 2021-09-03)New therapeutic strategies are direly needed in the fight against cancer. Over the last decade, several tumor ablation strategies have emerged as stand-alone or combination therapies. Histotripsy is the first completely ... -
Particle-mediated Histotripsy for the Targeted Treatment of Intraluminal Biofilms in Catheter-based Medical Devices
(American Association for the Advancement of Science (AAAS), 2022-08-09)Objective: This paper is an initial work towards developing particle-mediated histotripsy (PMH) as a novel method of treating catheter-based medical device (CBMD) intraluminal biofilms. Impact Statement: CBMDs commonly ... -
A Study on Electron Acceptor of Carbonaceous Materials for Highly Efficient Hydrogen Uptakes
(MDPI, 2021-12)Significant efforts have been directed toward the identification of carbonaceous materials that can be utilized for hydrogen uptake in order to develop on-board automotive systems with a gravimetric capacity of 5.5 wt.%, ... -
High intensity focused ultrasound for the treatment of solid tumors: a pilot study in canine cancer patients
(Taylor & Francis, 2022-01)Purpose: To investigate the safety, feasibility, and outcomes of High-Intensity Focused Ultrasound (HIFU) for the treatment of solid tumors in a spontaneous canine cancer model. Methods: Dogs diagnosed with subcutaneous ... -
An Emergency Powered Air-Purifying Respirator From Local Materials and its Efficacy Against Aerosolized Nanoparticles
(Sage Publications Inc, 2022-03)We describe an approach used by a rural healthcare provider to convert surgical helmets into emergency powered air-purifying respirators (PAPRs) at the onset of the COVID-19 pandemic. The approach uses common materials and ... -
Exploration of Novel Pathways Underlying Irreversible Electroporation Induced Anti-Tumor Immunity in Pancreatic Cancer
(Frontiers, 2022-03-18)Advancements in medical sciences and technologies have significantly improved the survival of many cancers; however, pancreatic cancer remains a deadly diagnosis. This malignancy is often diagnosed late in the disease when ... -
Transcriptional Interference Regulates the Evolutionary Development of Speech
(MDPI, 2022-07-04)The human capacity to speak is fundamental to our advanced intellectual, technological and social development. Yet so very little is known regarding the evolutionary genetics of speech or its relationship with the broader ... -
High-Frequency Irreversible Electroporation (H-FIRE) Induced Blood–Brain Barrier Disruption Is Mediated by Cytoskeletal Remodeling and Changes in Tight Junction Protein Regulation
(MDPI, 2022-06-11)Glioblastoma is the deadliest malignant brain tumor. Its location behind the blood–brain barrier (BBB) presents a therapeutic challenge by preventing effective delivery of most chemotherapeutics. H-FIRE is a novel ... -
Life Cycle Impact Assessment of Iron Oxide (Fe3O4/γ-Fe2O3) Nanoparticle Synthesis Routes
(2022)The synthesis of superparamagnetic iron oxide nanoparticles (FeOx-NPs) has rapidly developed over the past decade due to their wide-ranging applications in research and technology. However, at present there exists very ... -
A study on interfacial behaviors of epoxy/graphene oxide derived from pitch-based graphite fibers
(2021-11-12)Graphene oxide (GO) is a versatile material with inherent unique properties that can be used in a wide range of applications. GO is produced from graphitic materials including graphite, and its properties can depend on the ... -
Detectability of the Critically Endangered Araucaria angustifolia Tree Using Worldview-2 Images, Google Earth Engine and UAV-LiDAR
(MDPI, 2021-11-30)The Brazilian Atlantic Forest is a global biodiversity hotspot and has been extensively mapped using satellite remote sensing. However, past mapping focused on overall forest cover without consideration of keystone plant ... -
Establishing an immunocompromised porcine model of human cancer for novel therapy development with pancreatic adenocarcinoma and irreversible electroporation
(Nature Research, 2021-04-07)New therapies to treat pancreatic cancer are direly needed. However, efficacious interventions lack a strong preclinical model that can recapitulate patients’ anatomy and physiology. Likewise, the availability of human ... -
Bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic or artificial cavitation nuclei
(2021-03)The study described here examined the effects of cavitation nuclei characteristics on histotripsy. High-speed optical imaging was used to compare bubble cloud behavior and ablation capacity for histotripsy generated from ... -
3D printed graphene-based self-powered strain sensors for smart tires in autonomous vehicles
(2020-10-26)The transition of autonomous vehicles into fleets requires an advanced control system design that relies on continuous feedback from the tires. Smart tires enable continuous monitoring of dynamic parameters by combining ... -
The PathLinker app: Connect the dots in protein interaction networks
(F1000Research, 2017-01-20)PathLinker is a graph-theoretic algorithm for reconstructing the interactions in a signaling pathway of interest. It efficiently computes multiple short paths within a background protein interaction network from the receptors ... -
Automating the PathLinker app for Cytoscape
(F1000Research, 2018-06-12)PathLinker is a graph-theoretic algorithm originally developed to reconstruct the interactions in a signaling pathway of interest. It efficiently computes multiple short paths within a background protein interaction network ... -
Connectivity Measures for Signaling Pathway Topologies
(Virginia Tech, 2019-03-30)Characterizing cellular responses to different extrinsic signals is an active area of research, and curated pathway databases describe these complex signaling reactions. Here, we revisit a fundamental question in signaling ... -
Antibacterial efficacy of core-shell nanostructures encapsulating gentamicin against an in vivo intracellular Salmonella model
(Dove Medical Press, 2009-01-01)Pluronic based core-shell nanostructures encapsulating gentamicin were designed in this study. Block copolymers of (PAA(+/-)Na-b-(PEO-b-PPO-b-PEO)-b-PAA(+/-)Na) were blended with PAA(-) Na(+) and complexed with the ... -
The assembly of integrated rat intestinal-hepatocyte cultures
(2019-11)The jejunum is the segment of the small intestine responsible for several metabolism and biotransformation functions. In this report, we have cultured rat jejunum explants in vitro and integrated them with hepatocyte ... -
Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function
(Frontiers, 2019-11-28)Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious ...
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