Scholarly Works, Institute for Critical Technology and Applied Science (ICTAS)
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Research articles, presentations, and other scholarship
Recent Submissions
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The assembly of integrated rat intestinal-hepatocyte cultures
(2019-11)The jejunum is the segment of the small intestine responsible for several metabolism and biotransformation functions. In this report, we have cultured rat jejunum explants in vitro and integrated them with hepatocyte ... -
Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function
(Frontiers, 2019-11-28)Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious ... -
Nanoparticulate Nickel-Hosting Phases in Sulfidic Environments: Effects of Ferrous Iron and Bacterial Presence on Mineral Formation Mechanism and Solid-Phase Nickel Distribution
(Frontiers, 2019-06-26)The precipitation of nickel with sulfide is an important process governing the bioavailability of Ni in natural waters, and this process has the potential to effectively remove aqueous Ni contaminants in near-surface ... -
Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory
(Beilstein-Institut, 2015)To document the marketing and distribution of nano-enabled products into the commercial marketplace, the Woodrow Wilson International Center for Scholars and the Project on Emerging Nanotechnologies created the Nanotechnology ... -
High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity
(2019-06)Background: Despite promising treatments for breast cancer, mortality rates remain high and treatments for metastatic disease are limited. High-frequency irreversible electroporation (H-FIRE) is a novel tumor ablation ... -
Aerosol microdroplets exhibit a stable pH gradient
(2018-07-10)Suspended aqueous aerosol droplets (< 50 mu m) are microreactors for many important atmospheric reactions. In droplets and other aquatic environments, pH is arguably the key parameter dictating chemical and biological ... -
Continuous synthesis of Zn2Al-CO3 layered double hydroxides: a comparison of bench, pilot and industrial scale syntheses
(2019-04-01)Zn2Al-CO3 was produced continuously at bench (g h(-1)), pilot (100s g h -1) and industrial scale (10s kg h(-1)). Crystal domain length and BET surface area were similar at all three scales although there was a small increase ... -
Sequence verification of synthetic DNA by assembly of sequencing reads
(2013-01)Gene synthesis attempts to assemble user-defined DNA sequences with base-level precision. Verifying the sequences of construction intermediates and the final product of a gene synthesis project is a critical part of the ... -
XTALKDB: a database of signaling pathway crosstalk
(2017-01-04)Analysis of signaling pathways and their crosstalk is a cornerstone of systems biology. Thousands of papers have been published on these topics. Surprisingly, there is no database that carefully and explicitly documents ... -
Effects of internal electrode cooling on irreversible electroporation using a perfused organ model
(Taylor and Francis Ltd, 2018-05-28)Purpose: This study evaluates the effects of active electrode cooling, via internal fluid circulation, on the irreversible electroporation (IRE) lesion, deployed electric current and temperature changes using a perfused ... -
Processing method for grain-oriented lead-free piezoelectric Na0.5Bi0.5TiO3—BaTiO3 ceramics exhibiting giant performance
(United States Patent and Trademark Office, 2017-09-26)Textured ceramic compositions having improved piezoelectric characteristics as compared with their random counterparts are provided. Methods of making the compositions and devices using them are also included. More ... -
A high-energy-density sugar biobattery based on a synthetic enzymatic pathway
(Springer Nature, 2014-01)High-energy-density, green, safe batteries are highly desirable for meeting the rapidly growing needs of portable electronics. The incomplete oxidation of sugars mediated by one or a few enzymes in enzymatic fuel cells ... -
Giant piezoelectric voltage coefficient in grain-oriented modified PbTiO3 material
(Springer Nature, 2016-10-11)A rapid surge in the research on piezoelectric sensors is occurring with the arrival of the Internet of Things. Single-phase oxide piezoelectric materials with giant piezoelectric voltage coefficient (g, induced voltage ... -
Compositionally Graded Multilayer Ceramic Capacitors
(Springer Nature, 2017-09-27)Multilayer ceramic capacitors (MLCC) are widely used in consumer electronics. Here, we provide a transformative method for achieving high dielectric response and tunability over a wide temperature range through design of ... -
Transcriptomic Analysis of Hepatic Cells in Multicellular Organotypic Liver Models
(Springer Nature, 2018-07-27)Liver homeostasis requires the presence of both parenchymal and non-parenchymal cells (NPCs). However, systems biology studies of the liver have primarily focused on hepatocytes. Using an organotypic three-dimensional (3D) ... -
Nanomaterial enabled sensors for environmental contaminants
(2018-11-22)Abstract The need and desire to understand the environment, especially the quality of one’s local water and air, has continued to expand with the emergence of the digital age. The bottleneck in understanding ... -
3D Hepatic Cultures Simultaneously Maintain Primary Hepatocyte and Liver Sinusoidal Endothelial Cell Phenotypes
(PLOS, 2010-11-12)Developing in vitro engineered hepatic tissues that exhibit stable phenotype is a major challenge in the field of hepatic tissue engineering. However, the rapid dedifferentiation of hepatic parenchymal (hepatocytes) and ... -
Discovering Networks of Perturbed Biological Processes in Hepatocyte Cultures
(PLOS, 2011-01-05)The liver plays a vital role in glucose homeostasis, the synthesis of bile acids and the detoxification of foreign substances. Liver culture systems are widely used to test adverse effects of drugs and environmental ... -
Energy Efficiency Analysis: Biomass-to-Wheel Efficiency Related with Biofuels Production, Fuel Distribution, and Powertrain Systems
(PLOS, 2011-07-13)Background Energy efficiency analysis for different biomass-utilization scenarios would help make more informed decisions for developing future biomass-based transportation systems. Diverse biofuels produced from biomass ...
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