Now showing items 1-20 of 597

    • Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1 

      Roach, Tiffany G.; Lang, Helja K. M.; Xiong, Wen; Ryhanen, Samppa J.; Capelluto, Daniel G. S. (2021-02-26)
      Lysosomal degradation of ubiquitinated transmembrane protein receptors (cargo) relies on the function of Endosomal Sorting Complex Required for Transport (ESCRT) protein complexes. The ESCRT machinery is comprised of five ...
    • High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilB 

      Dye, Keane J.; Vogelaar, Nancy J.; Sobrado, Pablo; Yang, Zhaomin (2021-03)
      The bacterial type IV pilus (T4P) is a prominent virulence factor in many significant human pathogens, some of which have become increasingly antibiotic resistant. Antivirulence chemotherapeutics are considered a promising ...
    • Missing genes in the annotation of prokaryotic genomes 

      Warren, Andrew S.; Archuleta, Jeremy; Feng, Wu-chun; Setubal, João Carlos (BioMed Central, 2010)
      Background: Protein-coding gene detection in prokaryotic genomes is considered a much simpler problem than in intron-containing eukaryotic genomes. However there have been reports that prokaryotic gene finder programs have ...
    • SARS-CoV-2 Is a Culprit for Some, but Not All Acute Ischemic Strokes: A Report from the Multinational COVID-19 Stroke Study Group 

      Shahjouei, Shima; Anyaehie, Michelle; Koza, Eric; Tsivgoulis, Georgios; Naderi, Soheil; Mowla, Ashkan; Avula, Venkatesh; Vafaei Sadr, Alireza; Chaudhary, Durgesh; Farahmand, Ghasem; Griessenauer, Christoph; Azarpazhooh, Mahmoud Reza; Misra, Debdipto; Li, Jiang; Abedi, Vida; Zand, Ramin (2021-03)
      Background. SARS-CoV-2 infected patients are suggested to have a higher incidence of thrombotic events such as acute ischemic strokes (AIS). This study aimed at exploring vascular comorbidity patterns among SARS-CoV-2 ...
    • Nox4 mediates skeletal muscle metabolic responses to exercise 

      Specht, Kalyn S.; Kant, Shashi; Addington, Adele K.; McMillan, Ryan P.; Hulver, Matthew W.; Learnard, Heather; Campbell, Maura; Donnelly, Sarah R.; Caliz, Amada D.; Pei, Yongmei; Reif, Michaella M.; Bond, Jacob M.; DeMarco, Anthony; Craige, Branch; Keaney Jr, John F. d; Craige, Siobhan M. (2021-03)
      Objective: The immediate signals that couple exercise to metabolic adaptations are incompletely understood. Nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) produces reactive oxygen species (ROS) and plays a ...
    • Karyotype Aberrations in Action: The Evolution of Cancer Genomes and the Tumor Microenvironment 

      Baudoin, Nicolaas C.; Bloomfield, Mathew (MDPI, 2021-04-12)
      Cancer is a disease of cellular evolution. For this cellular evolution to take place, a population of cells must contain functional heterogeneity and an assessment of this heterogeneity in the form of natural selection. ...
    • Trends in ischemic stroke outcomes in a rural population in the United States 

      Chaudhary, Durgesh; Khan, Ayesha; Shahjouei, Shima; Gupta, Mudit; Lambert, Clare; Avula, Venkatesh; Schirmer, Clemens M.; Holland, Neil; Griessenauer, Christoph J.; Azarpazhooh, M. Reza; Li, Jiang; Abedi, Vida; Zand, Ramin (2021-03-15)
      Introduction: The stroke mortality rate has gradually declined due to improved interventions and controlled risk factors. We investigated the associated factors and trends in recurrence and all-cause mortality in ischemic ...
    • La Crosse Virus Shows Strain-Specific Differences in Pathogenesis 

      Wilson, Sarah N.; López, Krisangel; Coutermash-Ott, Sheryl; Auguste, Dawn I.; Porier, Danielle L.; Armstrong, Philip M.; Andreadis, Theodore G.; Eastwood, Gillian; Auguste, Albert J. (MDPI, 2021-03-29)
      La Crosse virus (LACV) is the leading cause of pediatric viral encephalitis in North America, and is an important public health pathogen. Historically, studies involving LACV pathogenesis have focused on lineage I strains, ...
    • Evaluation of Listeria monocytogenes and Staphylococcus aureus Survival and Growth during Cooling of Hams Cured with Natural-Source Nitrite 

      Wu, Jian; Acuff, Jennifer; Waterman, Kim; Ponder, Monica A. (International Association of Food Protection, 2021-02-01)
      Growing consumer demand for clean-label “natural” products has encouraged more meat processors to cure meat products with natural sources of nitrate or nitrite such as celery juice powder. One challenge for these producers ...
    • The new Internal Transcribed Spacer 2 diagnostic tool clarifies the taxonomic position and geographic distribution of the North American malaria vector Anopheles punctipennis 

      Hodge, James M.; Yurchenko, Andrey A.; Karagodin, Dmitriy A.; Masri, Reem A.; Smith, Ryan C.; Gordeev, Mikhail I.; Sharakhova, Maria V. (2021-03-10)
      Background The malaria mosquito Anopheles punctipennis, a widely distributed species in North America, is capable of transmitting human malaria and is actively involved in the transmission of the ungulate ...
    • Physical Mapping of the Anopheles (Nyssorhynchus) darlingi Genomic Scaffolds 

      Rafael, Míriam Silva; Bridi, Leticia Cegatti; Sharakhov, Igor V.; Marinotti, Osvaldo; Sharakhova, Maria V.; Timoshevskiy, Vladimir; Guimarães-Marques, Giselle Moura; Santos, Valéria Silva; da Silva, Carlos Gustavo Nunes; Astolfi-Filho, Spartaco; Tadei, Wanderli Pedro (MDPI, 2021-02-15)
      The genome assembly of Anopheles darlingi consists of 2221 scaffolds (N50 = 115,072 bp) and has a size spanning 136.94 Mbp. This assembly represents one of the smallest genomes among Anopheles species. ...
    • A Gene-Based Method for Cytogenetic Mapping of Repeat-Rich Mosquito Genomes 

      Masri, Reem A.; Karagodin, Dmitriy A.; Sharma, Atashi; Sharakhova, Maria V. (MDPI, 2021-02-06)
      Long-read sequencing technologies have opened up new avenues of research on the mosquito genome biology, enabling scientists to better understand the remarkable abilities of vectors for transmitting pathogens. Although new ...
    • Addressing the Contribution of Indirect Potable Reuse to Inland Freshwater Salinization 

      Bhide, Shantanu V.; Grant, Stanley B.; Parker, Emily A.; Rippy, Megan A.; Godrej, Adil; Kaushal, Sujay; Prelewicz, Gregory; Saji, Niffy; Curtis, Shannon; Vikesland, Peter J.; Maile-Moskowitz, Ayella; Edwards, Marc A.; Lopez, Kathryn; Birkland, Thomas A.; Schenk, Todd (2021-02-02)
      Inland freshwater salinity is rising worldwide, a phenomenon called the freshwater salinization syndrome (FSS). We investigate a potential conflict between managing the FSS and indirect potable reuse, the practice of ...
    • Unifying Advective and Diffusive Descriptions of Bedform Pumping in the Benthic Biolayer of Streams 

      Grant, Stanley B.; Monofy, Ahmed; Boano, Fulvio; Gomez-Velez, Jesus D.; Guymer, Ian; Harvey, Judson; Ghisalberti, Marco (2020-09-01)
      Many water quality and ecosystem functions performed by streams occur in the benthic biolayer, the biologically active upper (similar to 5 cm) layer of the streambed. Solute transport through the benthic biolayer is ...
    • A One-Dimensional Model for Turbulent Mixing in the Benthic Biolayer of Stream and Coastal Sediments 

      Grant, Stanley B.; Gomez-Velez, Jesus D.; Ghisalberti, Marco; Guymer, Ian; Boano, Fulvio; Roche, Kevin; Harvey, Judson (2020-12)
      In this paper, we develop and validate a rigorous modeling framework, based on Duhamel's Theorem, for the unsteady one-dimensional vertical transport of a solute across a flat sediment-water interface (SWI) and through the ...
    • Pomegranate: 2D segmentation and 3D reconstruction for fission yeast and other radially symmetric cells 

      Baybay, Erod Keaton; Esposito, Eric; Hauf, Silke (2020-10-06)
      Three-dimensional (3D) segmentation of cells in microscopy images is crucial to accurately capture signals that extend across optical sections. Using brightfield images for segmentation has the advantage of being minimally ...
    • The Beginning of the End: A Chromosomal Assembly of the New World Malaria Mosquito Ends with a Novel Telomere 

      Compton, Austin; Liang, Jiangtao; Chen, Chujia; Lukyanchikova, Varvara; Qi, Yumin; Potters, Mark; Settlage, Robert; Miller, Dustin; Deschamps, Stephane; Mao, Chunhong; Llaca, Victor; Sharakhov, Igor V.; Tu, Zhijian Jake (Genetics Society of America, 2020-10-01)
      Chromosome level assemblies are accumulating in various taxonomic groups including mosquitoes. However, even in the few reference-quality mosquito assemblies, a significant portion of the heterochromatic regions including ...
    • Research Needs, Challenges, and Strategic Approaches for Natural Hazards and Disaster Reconnaissance 

      Wartman, Joseph; Berman, Jeffrey W.; Bostrom, Ann; Miles, Scott; Olsen, Michael; Gurley, Kurtis; Irish, Jennifer L.; Lowes, Laura; Tanner, Troy; Dafni, Jake; Grilliot, Michael; Lyda, Andrew; Peltier, Jaqueline (2020-11-10)
      Natural hazards and disaster reconnaissance investigations have provided many lessons for the research and practice communities and have greatly improved our scientific understanding of extreme events. Yet, many challenges ...
    • Nix is a male-determining factor in the Asian tiger mosquito Aedes albopictus 

      Liu, Peiwen; Jin, Binbin; Li, Xiaocong; Zhao, Yijie; Gu, Jinbao; Biedler, James K.; Tu, Zhijian Jake; Chen, Xiao-Guang (2020-03)
      The initial signal that governs sex determination is highly variable among insects. A homolog of Nix, the male-determining factor in Aedes aegypti, was previously found in the Asian tiger mosquito Ae. albopictus. Here we ...
    • Safety of drug use in patients with a primary mitochondrial disease: An international Delphi-based consensus 

      De Vries, Maaike C.; Brown, David A.; Allen, Mitchell E.; Bindoff, Laurence; Gorman, Grainne S.; Karaa, Amel; Keshavan, Nandaki; Lamperti, Costanza; McFarland, Robert; Ng, Yi Shiau; O'Callaghan, Mar; Pitceathly, Robert D. S.; Rahman, Shamima; Russel, Frans G. M.; Varhaug, Kristin N.; Schirris, Tom J. J.; Mancuso, Michelangelo (2020-07)
      Clinical guidance is often sought when prescribing drugs for patients with primary mitochondrial disease. Theoretical considerations concerning drug safety in patients with mitochondrial disease may lead to unnecessary ...