Fralin Life Sciences Institute: Recent submissions
Now showing items 1-20 of 776
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Spatiotemporal and meteorological relationships in dengue transmission in the Dominican Republic, 2015–2019
(2023-06-02)Dengue has broadened its global distribution substantially in the past two decades, and many endemic areas are experiencing increases in incidence. The Dominican Republic recently experienced its two largest outbreaks to ... -
Rift Valley fever virus Gn V5-epitope tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production
(Academic Press, 2022-02)Rift Valley fever virus (RVFV) is an arbovirus that was first reported in the Rift Valley of Kenya which causes significant disease in humans and livestock. RVFV is a tri-segmented, negative-sense RNA virus consisting of ... -
Climate change and infectious disease: a review of evidence and research trends
(2023-05-16)Background Climate change presents an imminent threat to almost all biological systems across the globe. In recent years there have been a series of studies showing how changes in climate can impact ... -
Two mutations in the ORF1 of genotype 1 hepatitis E virus enhance virus replication and may associate with fulminant hepatic failure
(National Academy of Sciences, 2022-08)Hepatitis E virus (HEV) infection in pregnant women has a high incidence of developing fulminant hepatic failure (FHF) with significant mortality. Multiple amino acid changes in genotype 1 HEV (HEV-1) are reportedly linked ... -
Soap application alters mosquito-host interactions
(Cell Press, 2023-05)To find nutrients, mosquitoes use volatile organic compounds (VOCs) emitted by plants and animal hosts. These resources overlap in their chemical composition, and an important layer of information resides in VOCs’ relative ... -
Phafins Are More Than Phosphoinositide-Binding Proteins
(MDPI, 2023-04-30)Phafins are PH (Pleckstrin Homology) and FYVE (Fab1, YOTB, Vac1, and EEA1) domain-containing proteins. The Phafin protein family is classified into two groups based on their sequence homology and functional similarity: ... -
Transmission risk of Oropouche fever across the Americas
(2023-05-06)Background Vector-borne diseases (VBDs) are important contributors to the global burden of infectious diseases due to their epidemic potential, which can result in significant population and economic ... -
Steelhead trout (Oncorhynchus mykiss) fed probiotic during the earliest developmental stages have enhanced growth rates and intestinal microbiome bacterial diversity
(Frontiers, 2022-11)Sustainable aquaculture practices can help meet the increasing human demand for seafood, while easing pressures on natural fish populations. Studies aimed at increasing fish production in aquaculture have included supplementary ... -
Discovery of Two Inhibitors of the Type IV Pilus Assembly ATPase PilB as Potential Antivirulence Compounds
(American Society for Microbiology, 2022-12)Many bacterial pathogens use their type IV pilus (T4P) to facilitate and maintain an infection in a human host. Small-molecule inhibitors of the production or assembly of the T4P are promising for the treatment and prevention ... -
Perceived services and disservices of natural treatment systems for urban stormwater: Insight from the next generation of designers
(John Wiley & Sons Ltd, 2022)1. Natural treatment systems (NTS) for stormwater have the potential to provide a myriad of ecosystem services to society. Realizing this potential requires active collaboration among engineers, ecologists and landscape ... -
Diversity and genomics of giant viruses in the North Pacific Subtropical Gyre
(Frontiers, 2022-11)Large double-stranded DNA viruses of the phylum Nucleocytoviricota, often referred to as "giant viruses," are ubiquitous members of marine ecosystems that are important agents of mortality for eukaryotic plankton. Although ... -
Endogenous giant viruses contribute to intraspecies genomic variability in the model green alga Chlamydomonas reinhardtii
(Oxford University Press, 2022-11)Chlamydomonas reinhardtii is a unicellular eukaryotic alga that has been studied as a model organism for decades. Despite an extensive history as a model system, phylogenetic and genetic characteristics of viruses infecting ... -
Neglected tropical diseases risk correlates with poverty and early ecosystem destruction
(2023-04-10)Background Neglected tropical diseases affect the most vulnerable populations and cause chronic and debilitating disorders. Socioeconomic vulnerability is a well-known and important determinant of neglected ... -
Phylogenomics revealed migration routes and adaptive radiation timing of Holarctic malaria mosquito species of the Maculipennis Group
(2023-04-10)Background Phylogenetic analyses of closely related species of mosquitoes are important for better understanding the evolution of traits contributing to transmission of vector-borne diseases. Six out of ... -
Capturing complexity: Environmental change and relocation in the North Slope Borough, Alaska
(Elsevier, 2022-12)This paper explores the knowledge, attitudes, and behaviors about emerging hazards, environmental change, and relocation among community groups in Utqiaġvik (Barrow) of the North Slope Borough (NSB), Alaska. This region ... -
Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice
(Elsevier, 2023-01)Objective: Calorie restriction is a first-line treatment for overweight individuals with metabolic impairments. However, few patients can adhere to long-term calorie restriction. An alternative approach to calorie restriction ... -
Phylogenetic characterization of Orthobunyaviruses isolated from Trinidad shows evidence of natural reassortment
(Springer, 2023-02)The genus Orthobunyavirus is a diverse group of viruses in the family Peribunyaviridae, recently classified into 20 serogroups, and 103 virus species. Although most viruses within these serogroups are phylogenetically ... -
Ribavirin Treatment Failure-Associated Mutation, Y1320H, in the RNA-Dependent RNA Polymerase of Genotype 3 Hepatitis E Virus (HEV) Enhances Virus Replication in a Rabbit HEV Infection Model
(American Society for Microbiology, 2023-02-21)HEV-3 causes chronic hepatitis E that requires antiviral therapy in immunosuppressed individuals. RBV is the main therapeutic option for chronic hepatitis E as an off-label use. Chronic hepatitis E virus (HEV) infection ... -
Nitrate limitation in early Neoproterozoic oceans delayed the ecological rise of eukaryotes
(American Association for the Advancement of Science, 2023-03-23)The early Neoproterozoic Era witnessed the initial ecological rise of eukaryotes at ca. 800 Ma. To assess whether nitrate availability played an important role in this evolutionary event, we measured nitrogen isotope ... -
A comparative analysis exposes an amplification delay distinctive to SARS-CoV-2 Omicron variants of clinical and public health relevance
(Taylor & Francis, 2023)Mutations in the SARS-CoV-2 genome may negatively impact a diagnostic test, have no effect, or turn into an opportunity for rapid molecular screening of variants. Using an in-house Emergency Use Authorized RT-qPCR-based ...
