Recent Submissions

  • The adhesion function of the sodium channel beta subunit (beta 1) contributes to cardiac action potential propagation 

    Veeraraghavan, Rengasayee; Hoeker, Gregory S.; Alvarez-Laviada, Anita; Hoagland, Daniel; Wan, Xiaoping; King, D. Ryan; Sanchez-Alonso, Jose; Chen, Chunling; Jourdan, Jane; Isom, Lori L.; Deschenes, Isabelle; Smith, James W.; Gorelik, Julia; Poelzing, Steven; Gourdie, Robert G. (2018-08-14)
    Computational modeling indicates that cardiac conduction may involve ephaptic coupling - intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We ...
  • Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1 

    Holt, Leanne M.; Hernandez, Raymundo D.; Pacheco, Natasha L.; Ceja, Beatriz Torres; Hossain, Muhannah; Olsen, Michelle L. (2019-08-21)
    Brain-derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation of the CNS, including neuronal morphology and synapse refinement. Herein, we demonstrate astrocytes express high levels of ...
  • Proteomic study reveals a functional network of cancer markers in the G1-Stage of the breast cancer cell cycle 

    Tenga, Milagros J.; Lazar, Iulia M. (BMC, 2014)
    Background: Cancer cells are characterized by a deregulated cell cycle that facilitates abnormal proliferation by allowing cells to by-pass tightly regulated molecular checkpoints such as the G1/S restriction point. To ...
  • Ecology under lake ice 

    Hampton, Stephanie E.; Galloway, Aaron W. E.; Powers, Stephen M.; Ozersky, Ted; Woo, Kara H.; Batt, Ryan D.; Labou, Stephanie G.; O'Reilly, Catherine M.; Sharma, Sapna; Lottig, Noah R.; Stanley, Emily H.; North, Rebecca L.; Stockwell, Jason D.; Adrian, Rita; Weyhenmeyer, Gesa A.; Arvola, Lauri; Baulch, Helen M.; Bertani, Isabella; Bowman, Larry L., Jr.; Carey, Cayelan C.; Catalan, Jordi; Colom-Montero, William; Domine, Leah M.; Felip, Marisol; Granados, Ignacio; Gries, Corinna; Grossart, Hans-Peter; Haberman, Juta; Haldna, Marina; Hayden, Brian; Higgins, Scott N.; Jolley, Jeff C.; Kahilainen, Kimmo K.; Kaup, Enn; Kehoe, Michael J.; MacIntyre, Sally; Mackay, Anson W.; Mariash, Heather L.; Mckay, Robert M.; Nixdorf, Brigitte; Noges, Peeter; Noges, Tiina; Palmer, Michelle; Pierson, Don C.; Post, David M.; Pruett, Matthew J.; Rautio, Milla; Read, Jordan S.; Roberts, Sarah L.; Ruecker, Jacqueline; Sadro, Steven; Silow, Eugene A.; Smith, Derek E.; Sterner, Robert W.; Swann, George E. A.; Timofeyev, Maxim A.; Toro, Manuel; Twiss, Michael R.; Vogt, Richard J.; Watson, Susan B.; Whiteford, Erika J.; Xenopoulos, Marguerite A. (2017-01)
    Winter conditions are rapidly changing in temperate ecosystems, particularly for those that experience periods of snow and ice cover. Relatively little is known of winter ecology in these systems, due to a historical ...
  • Simulation Modeling of Lakes in Undergraduate and Graduate Classrooms Increases Comprehension of Climate Change Concepts and Experience with Computational Tools 

    Carey, Cayelan C.; Gougis, Rebekka Darner (2017-02)
    Ecosystem modeling is a critically important tool for environmental scientists, yet is rarely taught in undergraduate and graduate classrooms. To address this gap, we developed a teaching module that exposes students to a ...
  • A novel segmented-scintillator antineutrino detector 

    Abreu, Y.; Amhis, Y.; Arnold, L.; Ban, G.; Beaumont, W.; Bongrand, M.; Boursette, D.; Buhour, J. M.; Castle, B. C.; Clark, K.; Coupe, B.; Cucoanes, A. S.; Cussans, D.; De Roeck, A.; D'Hondt, J.; Durand, D.; Fallot, M.; Fresneau, S.; Ghys, L.; Giot, L.; Guillon, B.; Guilloux, G.; Ihantola, S.; Janssen, X.; Kalcheva, S.; Kalousis, L. N.; Koonen, E.; Labare, M.; Lehaut, G.; Mermans, J.; Michiels, I.; Moortgat, C.; Newbold, D.; Park, J.; Petridis, K.; Pinera, I. a; Pommery, G.; Popescu, L.; Pronost, G.; Rademacker, J.; Reynolds, A.; Ryckbosch, D.; Ryder, N.; Saunders, D.; Shitov, Yu. A.; Schune, M. -H.; Scovell, P. R.; Simard, L.; Vacheret, A.; Van Dyck, S.; Van Mulders, P.; van Remortel, N.; Vercaemer, S.; Waldron, A.; Weber, A.; Yermia, F. (2017-04)
    The next generation of very-short-baseline reactor experiments will require compact detectors operating at surface level and close to a nuclear reactor. This paper presents a new detector concept based on a composite solid ...
  • Intra- and inter-annual variability in metabolism in an oligotrophic lake 

    Richardson, David C.; Carey, Cayelan C.; Bruesewitz, Denise A.; Weathers, Kathleen C. (2017-04)
    Lakes are sentinels of change in the landscapes in which they are located. Changes in lake function are reflected in whole-system metabolism, which integrates ecosystem processes across spatial and temporal scales. Recent ...
  • On the diagonal subalgebra of an Ext algebra 

    Green, E. L.; Snashall, N.; Solberg, O.; Zacharia, D. (2017-04)
    Let R be a Koszul algebra over a field k and M be a linear R-module. We study a graded subalgebra Delta(M) of the Ext-algebra Ext(R)*(M, M) called the diagonal subalgebra and its properties. Applications to the Hochschild ...
  • When an enzyme isn't just an enzyme anymore 

    Winkel, Brenda S. J. (2017-03)
    In this issue (pages 1425-1440) Bross et al. provide evidence of surprising alternative functions for two isoforms of the plastid enzyme arogenate dehydratase. This study points to a previously unsuspected connection between ...
  • Permanent Draft Genome Sequence of Desulfurococcus amylolyticus Strain Z-533(T), a Peptide and Starch Degrader Isolated from Thermal Springs in the Kamchatka Peninsula and Kunashir Island, Russia 

    Susanti, Dwi; Johnson, Eric F.; Lapidus, Alla; Han, James; Reddy, T. B. K.; Mukherjee, Supratim; Pillay, Manoj; Perevalova, Anna A.; Ivanova, Natalia N.; Woyke, Tanja; Kyrpides, Nikos C.; Mukhopadhyay, Biswarup (2017-04)
    Desulfurococcus amylolyticus Z-533(T), a hyperthermophilic crenarcheon, ferments peptide and starch, generating acetate, isobutyrate, isovalerate, CO2, and hydrogen. Unlike D. amylolyticus Z-1312, it cannot use cellulose ...
  • A new method for measuring the neutron lifetime using an in situ neutron detector 

    Morris, C. L.; Adamek, E. R.; Broussard, L. J.; Callahan, N. B.; Clayton, S. M.; Cude-Woods, C.; Currie, S. A.; Ding, X.; Fox, W.; Hickerson, K. P.; Hoffbauer, M. A.; Holley, A. T.; Komives, A.; Liu, C. -Y.; Makela, M.; Pattie, R. W., Jr.; Ramsey, J.; Salvat, D. J.; Saunders, A.; Seestrom, S. J.; Sharapov, E. I.; Sjue, S. K.; Tang, Z.; Vanderwerp, J.; Vogelaar, B.; Walstrom, P. L.; Wang, Z.; Wei, Wanchun; Wexler, J. W.; Womack, T. L.; Young, A. R.; Zeck, B. A. (2017-05)
    In this paper, we describe a new method for measuring surviving neutrons in neutron lifetime measurements using bottled ultracold neutrons (UCN), which provides better characterization of systematic uncertainties and enables ...
  • Analysis of a conductive heat flow profile in the Ecuador Fracture Zone 

    Kolandaivelu, Kannikha Parameswari; Harris, Robert N.; Lowell, Robert P.; Alhamad, Ahmed; Gregory, Emma P. M.; Hobbs, Richard W. (2017-06)
    We report 18 new conductive heat flow measurements collected from a sediment pond located in the inactive part of the Ecuador Fracture Zone in the Panama Basin. The data were collected along an east-west transect coincident ...
  • Diversity in growth patterns among strains of the lethal fungal pathogen Batrachochytrium dendrobatidis across extended thermal optima 

    Voyles, Jamie; Johnson, Leah R.; Rohr, Jason; Kelly, Rochelle; Barron, Carley; Miller, Delaney; Minster, Josh; Rosenblum, Erica Bree (2017-06)
    The thermal sensitivities of organisms regulate a wide range of ecological interactions, including host-parasite dynamics. The effect of temperature on disease ecology can be remarkably complex in disease systems where the ...
  • Complete Genome Assembly of Pantoea stewartii subsp. stewartii DC283, a Corn Pathogen 

    Duong, Duy An; Stevens, Ann M.; Jensen, Roderick V. (2017-06)
    The phytopathogen Pantoea stewartii subsp. stewartii DC283 causes Stewart's wilt disease in corn after transmission from the corn flea beetle insect vector. Here, we report that the complete annotated genome of P. stewartii ...
  • The emergence of fast oscillations in a reduced primitive equation model and its implications for closure theories 

    Chekroun, Mickael D.; Liu, Honghu; McWilliams, James C. (2017-06-27)
    The problem of emergence of fast gravity-wave oscillations in rotating, stratified flow is reconsidered. Fast inertia-gravity oscillations have long been considered an impediment to initialization of weather forecasts, and ...
  • The evolution and role of the hyposphene-hypantrum articulation in Archosauria: phylogeny, size and/or mechanics? 

    Stefanic, Candice M.; Nesbitt, Sterling J. (Royal Society Publishing, 2019-10-02)
    Living members of Archosauria, the reptile clade containing Crocodylia and Aves, have a wide range of skeletal morphologies, ecologies and body size. The range of body size greatly increases when extinct archosaurs are ...
  • EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity 

    Sun, Zhixiong; Xu, Xiguang; He, Jianlin; Murray, Alexander; Sun, Ming-an; Wei, Xiaoran; Wang, Xia; McCoig, Emmarose; Xie, Evan; Jiang, Xi; Li, Liwu; Zhu, Jinsong; Chen, Jianjun; Morozov, Alexei; Pickrell, Alicia M.; Theus, Michelle H.; Xie, Hehuang (2019-08-29)
    Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life experience is translated into storable epigenetic information remains largely unknown. With unbiased data-driven approaches, we ...
  • Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells 

    Adamiak, Mateusz; Chelvarajan, Lakshman; Lynch, Kevin R.; Santos, Webster L.; Abdel-Latif, Ahmed; Ratajczak, Mariusz Z. (2017-09-12)
    Sphingosine-1-phosphate (S1P) is a bioactive lipid involved in cell signaling and, if released from cells, also plays a crucial role in regulating the trafficking of lympho-hematopoietic cells, including primitive hematopoietic ...
  • Does Rural Water System Design Matter? A Study of Productive Use of Water in Rural Nepal 

    GC, Raj K.; Ranganathan, Shyam; Hall, Ralph P. (MDPI, 2019-09-23)
    In Nepal, rural water systems (RWS) are classified by practitioners as single-use domestic water systems (SUS) or multiple-use water systems (MUS). In the rural hills of Nepal, subsistence farming communities typically use ...
  • Functionally graded ferroelectric polyetherimide composites for high temperature sensing 

    Khanbareh, H.; Hegde, M.; Bijleveld, J. C.; van der Zwaag, S.; Groen, P. (2017-09-28)
    High temperature ferroelectrics for thermally stable devices that can detect pressure and temperature are of great industrial interest. Here we describe composites of lead titanate (PT) particle-polyetherimide (PEI) polymers ...

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